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Title[redir]:
Prominin2 Drives Ferroptosis Resistance by Stimulating Multivesicular Body/Exosome-Mediated Iron Export - PMC
Description:
Ferroptosis, regulated cell death characterized by the iron-dependent accumulation of lethal lipid reactive oxygen species, contributes to tissue homeostasis and numerous pathologies, and it may be exploited for therapy. Cells differ in their ...
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Keywords {🔍}
cells, prominin, ferroptosis, rsl, hrs, mcfa, cell, hst, figure, control, dmso, iron, free, shown, expression, representative, independent, sirna, treated, replicates, google, scholar, doi, pubmed, pmc, gpx, article, tsg, transfected, quantified, adherent, inhibition, ferritin, resistance, specific, data, immunostained, scale, bar, experiment, death, green, red, image, formation, exosomes, figures, cancer, experiments, sensitivity,
Topics {✒️}
oncogenic-ras-harboring cancer cells pan-caspase inhibitor zvad-fmk prominin2-mediated mvb/exosome formation prominin2-mvb/exosome-ferritin pathway pmc beta search ferroportin-mediated iron export acs grant 130451-pf-17-105-01-csm prominin2-mediated mvb formation prominin2-expressing mda-mb-231 cells de-differentiated cell states prominin2-dependent mvb formation supplementary materials included recombinant proteins mitotracker supplementary material acknowledgments mvb/exosome iron transport transferrin/transferrin receptor system exosome-mediated export gsh-depleting agent erastin free intracellular iron quantifying free iron total free iron prominin2-mediated ferroptosis resistance multivesicular body formation multi-vesicular bodies free iron concentration mda-mb-231 cells increased lethal stress exposure prominin2-mediated mvb breast carcinoma cells pcmv-prominin2 expression vector adherent mda-mb-231 cells amino acid cystine friedmann angeli jp mvb/exosome pathway rsl3-induced cell death license information pmcid p53-mediated activity ferroptosis-resistant cell state ecm-detached cells compared lipid peroxidase pathway cell clustering mediated transmission electron microscopy poor clinical outcomes polyunsaturated fatty acids anti-cancer therapy breast cancer cells reactive lipid alcohols induces prominin2 expression nih grant ca218085 nih grant 1r01gm122923
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