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Keywords {🔍}

cell, gpx, cells, erastin, figure, death, ferroptosis, doi, lines, compounds, gsh, rsl, lipid, rrsl, lethality, cancer, pubmed, google, scholar, ros, induced, data, depletion, bjelr, fin, selective, lethal, treatment, activity, pmc, treated, table, probe, dpi, ptgs, ferroptotic, article, tumor, analysis, inhibition, bjderived, growth, sensitivity, bso, free, mice, knockdown, observed, compound, glutathione,

Topics {✒️}

tetrahydro-β-carboline ring system oncogenic-ras-harboring cancer cells display oncogenic-ras-synthetic-lethality lc-ms-based gpx4 assay bj-cell line system nih grant 1s10rr025431-01a1 nih grant 5r01-ca70823-15 bj-derived cell lines buthionine sulfoximine-induced cytostasis ras wild-type counterparts diazirine photo-cross-linking killed bj-derived cells pmc beta search lc-ms-based assay aif-mediated cell death endothelial cell-induced modification h-ras-induced growth lc-ms/ms analysis xeno-graft tumors derived targeting ros-scavenging systems bj-tert/lt/st cell death involving doxorubicin-mediated dna damage protein l-isoaspartyl methyltransferase improved metabolic stability bodipy-c11 staining revealed larger drug-screening analysis individual concentration-dependent curve authentic pc-ooh standard genotype-selective antitumor agents gsh-depleting reagents elevated bodipy-c11 staining data cell lysate/methanol mixture including ras-transformed fibroblasts erastin-induced cell death rsl3-induced cell death serum-free media reduce exogenous pc-ooh gpx4-regulated ferroptosis pathway lc-ms/ms extended experimental procedures 7α-cholesterol-ooh decreased oxidative stress-induced apoptosis bj-derived fibroblasts reported ros-generating activity o'donnell supplementary materials included wild-type ras athymic nude mice bj-derived cells

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