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We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC8299533/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC8299533/. The analysis below is for the second page.
Title[redir]:
Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers - PMC
Description:
Cancer cells rewire their metabolism and rely on endogenous antioxidants to mitigate lethal oxidative damage to lipids. However, the metabolic processes which modulate the response to lipid peroxidation are poorly defined. Using genetic screens, we ...
Title[redir]:
Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers - PMC
Description:
Cancer cells rewire their metabolism and rely on endogenous antioxidants to mitigate lethal oxidative damage to lipids. However, the metabolic processes which modulate the response to lipid peroxidation are poorly defined. Using genetic screens, we ...
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Keywords {🔍}
cells, cell, data, fig, lipid, jurkat, type, scholar, wild, doi, gpx, rsl, extended, knockout, shown, google, pubmed, cystine, sfxn, biological, gch, treated, ferroptosis, inhibition, log, replicates, peroxidation, change, pmc, erastin, blue, free, fold, number, article, analysis, cancer, genes, loss, left, metabolic, depletion, gene, proliferation, lines, untreated, representative, figure, dhfr, screen,
Topics {✒️}
supp table3 nihms1696190-supplement-supp__table3 reversed phase nano-lc-ms/ms pmxs-sfxn1-ires-gfp expressing cells recently characterized α-toh/coq10/fsp13 rplc-ion-trap-ftms method pan-nos inhibitor l-nio data-dependent ms/ms scans lc/ms grade chloroform apoptosis inhibitor q-vd-oph α-toh-inhibited oxidation proceeded guide resistant flag-sfxn1 pmxs-ires-gfp linearized crispr-cas9 genetic screen pmxs-ires-blast linearized anti-ha magnetic beads masked nitrile-oxide electrophiles nicotinamide-adenine dinucleotide phosphate protein n-terminal acetylation hrp-conjugated anti-rabbit iron-sulfur cluster binding pmc beta search unpaired t-test corrected fluorescence-enabled inhibited autoxidation crispr-cas9 screens potent radical-trapping antioxidant spr-ko jurkat cells lipophilic radical-trapping antioxidants α-toh/bh2/dhfr system expressing a375 cells radical-trapping antioxidant chemistry revealed protein-protein interactions vanquish uplc system gch1-null cell lines flag-gfp control immunoprecipitation paraquat-induced cell toxicity myc-tagged omp25 enhance anti-ferroptotic defenses lenticrispr-v2-puro linearized common water-soluble antioxidants hek 293t cells jurkat cells untreated lc/ms analysis α-toh derived radicals sgrna-expressing vector pmxs-ires-blast lipid-derived peroxyl radicals ovarian cancer cells protect bh4-depleted cells flag-sfxn1 cdna guide resistant gch1
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