
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Multi-stage differentiation defines melanoma subtypes with differential vulnerability to drug-induced iron-dependent oxidative stress - PMC
Description:
Malignant transformation can result in melanoma cells that resemble different stages of their embryonic development. Our gene expression analysis of human melanoma cell lines and patient tumors revealed that melanoma follows a two-dimensional ...
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Keywords {🔍}
cell, doi, melanoma, differentiation, cells, figure, lines, scholar, google, pubmed, pmc, treatment, article, expression, ferroptosis, dedifferentiation, free, subtype, sensitivity, resistance, analysis, gene, genes, data, erastin, cancer, subtypes, line, performed, trajectory, drugs, immune, mitf, values, nature, tumor, neural, levels, profiles, inducing, tumors, increased, braf, observed, table, enrichment, signature, death, control, model,
Topics {✒️}
pan-caspase inhibitor z-vad-fmk zeb2-mitf-zeb1 transcriptional network oncogenic-ras-harboring cancer cells cross-platform/cross-batch application european genome-phenome archive [google scholar] müller pmc beta search invasive/inflammation-related gene sets combining dependent p-values irdye-conjugated secondary antibodies average signature z-scores gov/programs/ctd2/data-portal garcia-corsini family fund atp-based celltiter-glo interactive web-interface resource drug-induced redox stress star methods contact h2o2-induced cell death multi-stage subtypes provide cell line-trained classifier embryonic emt-inducers drives semi-quantitatively reflect dedifferentiation low-sample size data rank-based enrichment analysis parametric kruskal-wallis test prolonged treatment time-point inflammation-related gene sets examined phospho-erk levels progressive step-wise states observe subtype-specific sensitivity single-cell rna-seq inflammation-induced reversible dedifferentiation emphasizes melanoma-specific genes erastin-induced cell death wnt/beta-catenin signaling high-throughput sequencing data jonckheere–terpstra test pro-inflammatory cytokine responsiveness undifferentiated-neural crest pair vemurafenib-induced dedifferentiation including differentiated mitf-positive state rsl3-induced cell death inflammatory mitf-low melanomas treatment-induced differentiation transitions mass spectrometry-based metabolomics exhibited subtype-specific sensitivity tumor-derived cell lines disease-related pigmentation defects immune-specific cd markers long-term persisting cells
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- How much revenue does https://scholar.google.com/scholar_lookup?journal=Nat.%20Commun&title=MITF%20and%20c-Jun%20antagonism%20interconnects%20melanoma%20dedifferentiation%20with%20pro-inflammatory%20cytokine%20responsiveness%20and%20myeloid%20cell%20recruitment&author=S%20Riesenberg&author=A%20Groetchen&author=R%20Siddaway&author=T%20Bald&author=J%20Reinhardt&volume=6&publication_year=2015&pages=8755&pmid=26530832&doi=10.1038/ncomms9755& produce monthly?
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