
NCBI . NLM . NIH . GOV {
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Title[redir]:
Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration - PMC
Description:
Cerebral selenium (Se) deficiency is associated with neurological phenotypes including seizures and ataxia. We wanted to define whether neurons require selenoprotein expression and which selenoproteins are most important, and explore the possible ...
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Keywords {🔍}
doi, mice, pubmed, google, scholar, neurons, interneurons, selenoprotein, gpx, expression, brain, selenoproteins, neuronal, fig, pmc, interneuron, cortical, cells, cell, article, selenium, activity, reduced, control, trsp, camkcretrspflfl, free, development, vitamin, function, phenotype, cortex, tαcretrspflfl, neurodegeneration, culture, hippocampal, schweizer, deficiency, neurological, animals, mutant, gad, mouse, essential, role, loss, slices, seizures, survival, vitro,
Topics {✒️}
p12 tα1-cre/trspfl/fl mice generated camk-cre/gpx4fl/fl mice p9 tα1-cre/trspfl/fl brains camk-cre/trspfl/fl mouse brains p9 tα1-cre/trspfl/fl tα1-cre/trspfl/fl mice camk-cre/trspfl/fl mice camk-cre/gpx4fl/fl mice widespread incamk-cre/trspfl/fl low-resistance patch-pipettes filled tα1-cre/trspfl/fl camk-cre/trspfl/fl camk-cre/gpx4fl/fl neuron-specific trsp-deficient mice gene encoding trna[ser]sec allan-herndon-dudley syndrome restrict cre-mediated recombination cre-transgenic mouse strain medial septum/diagonal band pmc beta search interface-type recording chamber cre recombinase-mediated deletion sepp/apoer2-mediated se uptake rescue trsp-mutant neurons trna[ser]sec gene brain-specific gene inactivation conditional trsp-knockout mice neuron-specific trsp ablation camk-cre mice sepp-deficient mice generated sepp-deficient mice suggests sustain trsp-deficient neurons lipoxygenase-dependent apoptotic pathway free-floating sections aif-mediated cell death cre-mediated recombination gpx4-deficient mice displayed unaltered input/output function thyroid hormone metabolism thyroid hormone insufficiency supplementary materials included polyclonal rabbit α-pv trna[ser]sec rabbit α-cr antibodies cultured wild-type neurons neuron-specific ablation trsp-deficient mice trsp mutant mice trsp-mutant mice primary neuron culture
Questions {❓}
- How can redox state or lipid peroxidation influence interneuron differentiation?
- Oxidative stress in neurodegeneration: cause or consequence?
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