
NCBI . NLM . NIH . GOV {
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Title[redir]:
Salinomycin kills cancer stem cells by sequestering iron in lysosomes - PMC
Description:
Cancer stem cells (CSCs) represent a subset of cells within tumours that exhibit self-renewal and tumour seeding capacity. CSCs are typically refractory to conventional treatments and have been associated to metastasis and relapse. Salinomycin ...
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Keywords {๐}
cells, doi, sal, iron, fig, google, scholar, cell, pubmed, pmc, free, cancer, article, treated, supplementary, hmler, cscs, data, lysosomal, cdlow, chem, stem, breast, effect, ros, sigma, death, aldrich, salinomycin, ferritin, nat, bars, min, lysosomes, selective, flow, cytometry, levels, derivatives, analysis, ironii, production, small, icscla, fluorescence, signals, derivative, activity, membrane, aldh,
Topics {โ๏ธ}
c-ring-modified salinomycin analogues ras-related protein rab-7a necrosis inhibitors z-vad-fmk nod/scid mice treated c18=c19 double bond protein disulfide-isomerase a3 pmc beta search sodium-binding benzofuran isophtalate ras-related protein rab7 tight iron-chelating ligands deltavision real-time microscope bravo-san pedro jm luminal lineage-driving oncogene reactive oxygen species provided icscl-10a2 cells high-resolution fluorescence images decreased tumour-seeding capacity n-acetyl-l-cysteine repress e-cadherin expression40 c18โc19 vinylic protons redox-inactive iron complex high-throughput phenotypic screening6โ8 endocytosis-independent entry mechanism icscl-10a2 cells treated doseโresponse viability curves z-vad-fmk endoplasmic reticulum stress [google scholar] 11 [google scholar] 30 fondation de france stains nuclear dna 5 ฮผm cm-h2dcf-da human cancer cells human breast cscs6 small molecules derived visualize nuclear dna high-throughput screening breast cancer stem nat rev cancer aldehyde dehydrogenase positive high-resolution microscopy primary breast tumors icscl-10a2 cells20 leukemia stem cells cancer stem cells cancer stem cells small molecules block primary breast cells icscl-10a2 cells cm-h2dcf-da
Questions {โ}
- Tackling the cancer stem cellsโwhat challenges do they pose?
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Analytics and Tracking {๐}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {๐}
- jQuery
- jQuery module (jquery-3.6.0)
- Raphael
- Zoom.js
Emails and Hosting {โ๏ธ}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {๐ฆ}
- Ncbi