
NCBI . NLM . NIH . GOV {
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Title[redir]:
FINO2 Initiates Ferroptosis Through GPX4 Inactivation and Iron Oxidation - PMC
Description:
Ferroptosis is a non-apoptotic form of regulated cell death caused by the failure of the glutathione-dependent lipid-peroxide-scavenging network. FINO2 is an endoperoxide-containing 1,2-dioxolane that can initiate ferroptosis selectively in ...
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Keywords {🔍}
fino, ferroptosis, cells, doi, cell, gpx, figure, google, scholar, erastin, pubmed, rsl, activity, iron, pmc, lipid, data, chem, death, treated, min, article, treatment, supplementary, free, samples, acid, dmso, performed, inducers, protein, peroxide, oxidation, peroxidation, independent, gsh, vehicle, cancer, fin, plotted, inhibitor, arachidonic, mechanism, group, compounds, lethality, assay, derivatives, system, experiments,
Topics {✒️}
glutathione-dependent lipid-peroxide-scavenging network endogenous lipid-peroxide-scavenging network lipid-peroxide-reducing enzyme gpx4 cyanine-based fluorescent probe regioselective cobalt-catalyzed peroxidation nadph-regenerating system solution generate oxygen-centered radicals kill oncogenic bj-elr thiobarbituric-acid-reactive substances pmc beta search high-throughput screening libraries liquid chromatography-mass spectrometry mitochondria-targeted nitroxide xjb-5-131 1h-15n hsqc spectra artemisinin-derived sesquiterpene lactones placebo-controlled pilot study dana-farber cancer institute terpenoid-derived spirocyclic furans require alox-mediated peroxidation bis-allylic position creates s-lens rf level cell-line selectivity improves selective pro-oxidant molecule apoptosis inhibitor zvad-fmk cell death-suppressing compounds lc-ms-based assay cell-free assays particulate-free plasma prevent fino2-induced death glutamate-free medium silyl enol ethers 1h-nmr showing degradation fluorescent enzymatic assay selenium-independent glutathione peroxidases regulated process began 5 μm c11-bodipy deuterated arachidonic acid tert-butyl hydroperoxide highly selective detection cell-free experiments deuterated arachidonic acids full ms scan engage labile iron quantitative pcr reactions oxidative stress caused programmed cell death reactive fluorescent reporter active site ligand ferroptotic cell death 15n carrier frequency
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