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Keywords {🔍}

cells, cell, ferroptosis, doi, nutlin, death, expression, control, figure, pretreatment, erastin, pmc, gsh, figures, system, pubmed, google, scholar, cystine, tpko, article, stabilization, treatment, free, erastininduced, cancer, cellcycle, activity, levels, wildtype, pretreated, response, dmso, dixon, target, deprivation, onset, time, tumor, cdkna, glutathione, arrest, results, inhibition, data, metabolic, sensitivity, transcriptional, jiang, lines,

Topics {✒️}

p53-mediated cell-cycle arrest trp53lsl-wt/lsl-wt supplemental experimental procedures stress-responsive transcription factor wild-type p53 renders express wild-type p53 pmc beta search expressed wild-type p53 metabolic indicator pres-toblue cancer-related mutant forms acetylation-defective p53 mutants cdk-regulated metabolic enzymes complete cell-cycle arrest erastin2-induced ferropto-sis wild-type p53 expression p53 post-translational modifications p53-dependent metabolic remodelling wild-type p53 delays wild-type p53 stabilization cell-cycle arrest caused inhibit cell-cycle progression crispr/cas9 genome editing p53-dependent transcriptional effect cyclin-dependent kinase fine-tune ferroptosis sensitivity fluorescence-activated cell sorting repressing slc7a11/xct expression altered xct/slc7a11 expression scalable time-lapse analysis 2-fold dose-response series erastin2-induced cell death mkate2-expressing ht-1080 parental p53 tumor suppressor prevent tumor formation clonal tp53 knockout p53-mediated tumour suppression coordinated p53-mediated response ad-cre cells prior system xc− activity wild-type p53 erastin2-induced ferroptosis relative license information pmcid system xc− function nrf2-mediated antioxidant response p21-stimulated nrf2 activity specific antioxidant inhibitor supplementary materials included metabolic stress induced p53-mediated transcription p53 suppresses ferroptosis

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