
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling - PMC
Description:
Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. Oxidative stress refers to the imbalance due to excess ROS or oxidants over the ...
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๐ Phenomenal Traffic: 5M - 10M visitors per month
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Keywords {๐}
doi, pubmed, google, scholar, ros, free, pmc, article, oxidative, protein, redox, pshc, fig, biol, signaling, cell, cys, stress, irp, iron, ref, activation, regulation, atm, binding, domain, kinase, cellular, pathways, nrf, oxidation, response, activated, shown, transcription, dna, mol, chem, regulated, phosphorylation, activity, results, acid, mapk, factor, proteins, cluster, factors, conditions, formation,
Topics {โ๏ธ}
/v-h-c-x-x-g-x-x-r f-box/lrr-repeat protein 5 keap1/cullin-3 e3-ubiquitin ligase c-jun n-terminal kinases cullin-3 e3-ubiquitin ligase p66shc phospho-ser36-pro37 bond double-strand dna breaks basal c-terminal interaction extracellular signal-related kinases pmc beta search b-zip transcription factor platelet-derived growth factor mrn/ser-1981 autophosphorylation-independent manner primary post-transcriptional mechanism b-zip transcriptional repressor b-zip transcription factors iron-deficient conditions facilitate cgmp-dependent protein kinase iron-rich cells synthesize normal p66shc fibro-blasts mitogen-activated protein kinase 4feโ4s cluster implies iron-catalyzed oxidative stress phosphoinositide-dependent protein kinase n-terminus ch2 domain p66shc-deficient mouse fibroblasts hypoxia inducible factor-2ฮฑ ireโirp regulatory system redox-dependent reversible tetramerization ironโsulfur cluster proteins indirect ros-mediated damage iron-deficient cells produce family serine/threonine mapkkk apurinic/apyrimidinic endonuclease domain copper-dependent ros generation c-terminal region ros-mediated phosphorylation sites blocking n-terminal b-zip family ap-1/nfkb-independent manner ap-endonuclease activity domain increasing irpโire interaction stem-loop structure composed preventing fbxl5-dependent ubiquitination c-terminal domain human shca gene n-terminus region p66shc-deficient mice reactive oxygen species amino acid sequence
Questions {โ}
- What downstream signaling events are regulated by activated ATM in response to ROS?
- What is the initial and direct impact of oxidative or genotoxic stress on p66Shc and how is p66Shc activated?
- While there exists ample evidence demonstrating the role of ROS in regulating cellular signaling pathways, the question that is raised is exactly how do ROS initiate cellular signaling?
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- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=EMBO%20J&author=S%20Xanthoudakis&author=T%20Curran&volume=11&publication_year=1992&pages=653-665&pmid=1537340&doi=10.1002/j.1460-2075.1992.tb05097.x&?
- How much revenue does https://doi.org/10.1073/pnas.88.24.11450 produce monthly?
- What's the financial intake of https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&author=B%20Demple&author=T%20Herman&author=DS%20Chen&volume=88&publication_year=1991&pages=11450-11454&pmid=1722334&doi=10.1073/pnas.88.24.11450&?
- What's https://doi.org/10.1093/nar/19.20.5519's gross income?
- Check the income stats for https://scholar.google.com/scholar_lookup?journal=Nucleic%20Acids%20Res&author=CN%20Robson&author=ID%20Hickson&volume=19&publication_year=1991&pages=5519-5523&pmid=1719477&doi=10.1093/nar/19.20.5519&
- What's the financial gain of https://doi.org/10.1089/ars.2008.2194?
- How much does https://scholar.google.com/scholar_lookup?journal=Antioxid%20Redox%20Signal&author=G%20Tell&author=F%20Quadrifoglio&author=C%20Tiribelli&author=MR%20Kelley&volume=11&publication_year=2009&pages=601-620&pmid=18976116&doi=10.1089/ars.2008.2194& pull in monthly?
- What's the monthly money flow for https://doi.org/10.1073/pnas.91.1.23?
- Learn how profitable https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&author=S%20Xanthoudakis&author=GG%20Miao&author=T%20Curran&volume=91&publication_year=1994&pages=23-27&pmid=7506414&doi=10.1073/pnas.91.1.23& is on a monthly basis
- How much does https://doi.org/10.1128/mcb.13.9.5370 gross monthly?
- Learn about the earnings of https://scholar.google.com/scholar_lookup?journal=Mol%20Cell%20Biol&author=LJ%20Walker&author=CN%20Robson&author=E%20Black&author=D%20Gillespie&author=ID%20Hickson&volume=13&publication_year=1993&pages=5370-5376&pmid=8355688&doi=10.1128/mcb.13.9.5370&
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- How much cash flow does https://scholar.google.com/scholar_lookup?journal=Science&author=C%20Abate&author=L%20Patel&author=FJ%20Rauscher&author=T%20Curran&volume=249&publication_year=1990&pages=1157-1161&pmid=2118682&doi=10.1126/science.2118682& have monthly?
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- What is the monthly revenue of https://doi.org/10.1038/sj.onc.1205288?
- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Oncogene&author=D%20Bloom&author=S%20Dhakshinamoorthy&author=AK%20Jaiswal&volume=21&publication_year=2002&pages=2191-2200&pmid=11948402&doi=10.1038/sj.onc.1205288&?
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- What's the income of https://scholar.google.com/scholar_lookup?journal=J%20Mol%20Biol&author=I%20Goren&author=E%20Tavor&author=A%20Goldblum&author=A%20Honigman&volume=313&publication_year=2001&pages=695-709&pmid=11697898&doi=10.1006/jmbi.2001.5064&?
- How much does https://doi.org/10.1128/MCB.26.7.2845-2856.2006 make?
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Mol%20Cell%20Biol&author=K%20Iwasaki&author=EL%20Mackenzie&author=K%20Hailemariam&author=K%20Sakamoto&author=Y%20Tsuji&volume=26&publication_year=2006&pages=2845-2856&pmid=16537925&doi=10.1128/MCB.26.7.2845-2856.2006&?
- How much does https://doi.org/10.1089/ars.2008.2198 make?
- Get to know https://scholar.google.com/scholar_lookup?journal=Antioxid%20Redox%20Signal&author=KK%20Bhakat&author=AK%20Mantha&author=S%20Mitra&volume=11&publication_year=2009&pages=621-638&pmid=18715144&doi=10.1089/ars.2008.2198&'s earnings
- What are the total earnings of https://doi.org/10.1073/pnas.94.8.3633?
- How much does https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&author=K%20Hirota&author=M%20Matsui&author=S%20Iwata&author=A%20Nishiyama&author=K%20Mori&volume=94&publication_year=1997&pages=3633-3638&pmid=9108029&doi=10.1073/pnas.94.8.3633& pull in?
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- How much does https://scholar.google.com/scholar_lookup?journal=J%20Biol%20Chem&author=M%20Ueno&author=H%20Masutani&author=RJ%20Arai&author=A%20Yamauchi&author=K%20Hirota&volume=274&publication_year=1999&pages=35809-35815&pmid=10585464&doi=10.1074/jbc.274.50.35809& gross monthly?
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- Find out how much https://scholar.google.com/scholar_lookup?journal=Annu%20Rev%20Biochem&author=A%20Holmgren&volume=54&publication_year=1985&pages=237-271&pmid=3896121&doi=10.1146/annurev.bi.54.070185.001321& earns monthly
- See how much https://doi.org/10.1093/nar/28.5.1099 makes per month
- How much does https://scholar.google.com/scholar_lookup?journal=Nucleic%20Acids%20Res&author=G%20Tell&author=A%20Zecca&author=L%20Pellizzari&author=P%20Spessotto&author=A%20Colombatti&volume=28&publication_year=2000&pages=1099-1105&pmid=10666449&doi=10.1093/nar/28.5.1099& pull in monthly?
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- How much does https://scholar.google.com/scholar_lookup?journal=Nucleic%20Acids%20Res&author=EB%20Jackson&author=CA%20Theriot&author=R%20Chattopadhyay&author=S%20Mitra&author=T%20Izumi&volume=33&publication_year=2005&pages=3303-3312&pmid=15942031&doi=10.1093/nar/gki641& bring in each month?
- What are the total earnings of https://doi.org/10.1093/nar/gkl1163?
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- How much money does https://scholar.google.com/scholar_lookup?journal=Mol%20Immunol&author=S%20Merluzzi&author=O%20D%E2%80%99Orlando&author=A%20Leonardi&author=G%20Vitale&author=C%20Pucillo&volume=45&publication_year=2008&pages=76-86&pmid=17599408&doi=10.1016/j.molimm.2007.05.010& make?
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- How much money does https://doi.org/10.1016/s0891-5849(00)00306-3 generate?
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- What is the earnings of https://doi.org/10.1128/MCB.00700-06?
- What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=Mol%20Cell%20Biol&author=J%20Zhang&author=T%20Ohta&author=A%20Maruyama&author=T%20Hosoya&author=K%20Nishikawa&volume=26&publication_year=2006&pages=7942-7952&pmid=16923960&doi=10.1128/MCB.00700-06&?
- What is the earnings of https://doi.org/10.1128/mcb.10.9.4967?
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Mol%20Cell%20Biol&author=SM%20Keyse&author=LA%20Applegate&author=Y%20Tromvoukis&author=RM%20Tyrrell&volume=10&publication_year=1990&pages=4967-4969&pmid=2388632&doi=10.1128/mcb.10.9.4967&?
- How much does https://doi.org/10.1128/mcb.20.16.5818-5827.2000 generate monthly?
- How much profit does https://scholar.google.com/scholar_lookup?journal=Mol%20Cell%20Biol&author=Y%20Tsuji&author=H%20Ayaki&author=SP%20Whitman&author=CS%20Morrow&author=SV%20Torti&volume=20&publication_year=2000&pages=5818-5827&pmid=10913165&doi=10.1128/mcb.20.16.5818-5827.2000& generate?
- What are the total earnings of https://doi.org/10.1038/sj.onc.1208901?
- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Oncogene&author=Y%20Tsuji&volume=24&publication_year=2005&pages=7567-7578&pmid=16007120&doi=10.1038/sj.onc.1208901&?
- How much does https://doi.org/10.1146/annurev.pharmtox.43.100901.140229 net monthly?
- How much does https://scholar.google.com/scholar_lookup?journal=Annu%20Rev%20Pharmacol%20Toxicol&author=T%20Nguyen&author=PJ%20Sherratt&author=CB%20Pickett&volume=43&publication_year=2003&pages=233-260&pmid=12359864&doi=10.1146/annurev.pharmtox.43.100901.140229& earn?
- What are the total earnings of https://doi.org/10.1073/pnas.94.10.5361?
- How much income does https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&author=WW%20Wasserman&author=WE%20Fahl&volume=94&publication_year=1997&pages=5361-5366&pmid=9144242&doi=10.1073/pnas.94.10.5361& have?
- How much does https://doi.org/10.1016/j.freeradbiomed.2008.01.031 net monthly?
- How much does https://scholar.google.com/scholar_lookup?journal=Free%20Radic%20Biol%20Med&author=EL%20MacKenzie&author=PD%20Ray&author=Y%20Tsuji&volume=44&publication_year=2008&pages=1762-1771&pmid=18325346&doi=10.1016/j.freeradbiomed.2008.01.031& make?
- https://doi.org/10.1006/abbi.1998.0895's revenue stream
- Discover the revenue of https://scholar.google.com/scholar_lookup?journal=Arch%20Biochem%20Biophys&author=RB%20Tjalkens&author=SW%20Luckey&author=DJ%20Kroll&author=DR%20Petersen&volume=359&publication_year=1998&pages=42-50&pmid=9799558&doi=10.1006/abbi.1998.0895&
- How much money does https://doi.org/10.1093/nar/gkm638 make?
- What is the earnings of https://scholar.google.com/scholar_lookup?journal=Nucleic%20Acids%20Res&author=JF%20Reichard&author=GT%20Motz&author=A%20Puga&volume=35&publication_year=2007&pages=7074-7086&pmid=17942419&doi=10.1093/nar/gkm638&?
- What is the earnings of https://doi.org/10.1073/pnas.0505148102?
- What's the financial outcome of https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&author=KJ%20Hintze&author=EC%20Theil&volume=102&publication_year=2005&pages=15048-15052&pmid=16217041&doi=10.1073/pnas.0505148102&?
- Explore the financials of https://doi.org/10.2174/157340606776930709
- Revenue of https://scholar.google.com/scholar_lookup?journal=Med%20Chem&author=TC%20Hsieh&author=X%20Lu&author=Z%20Wang&author=JM%20Wu&volume=2&publication_year=2006&pages=275-285&pmid=16948474&doi=10.2174/157340606776930709&
- How much does https://doi.org/10.1101/gad.13.1.76 rake in every month?
- What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Genes%20Dev&author=K%20Itoh&author=N%20Wakabayashi&author=Y%20Katoh&author=T%20Ishii&author=K%20Igarashi&volume=13&publication_year=1999&pages=76-86&pmid=9887101&doi=10.1101/gad.13.1.76&?
- How much does https://doi.org/10.1074/jbc.R900010200 net monthly?
- How much revenue does https://scholar.google.com/scholar_lookup?journal=J%20Biol%20Chem&author=T%20Nguyen&author=P%20Nioi&author=CB%20Pickett&volume=284&publication_year=2009&pages=13291-13295&pmid=19182219&doi=10.1074/jbc.R900010200& bring in?
- How much income is https://doi.org/10.1128/MCB.25.1.162-171.2005 earning monthly?
- Find out how much https://scholar.google.com/scholar_lookup?journal=Mol%20Cell%20Biol&author=M%20Furukawa&author=Y%20Xiong&volume=25&publication_year=2005&pages=162-171&pmid=15601839&doi=10.1128/MCB.25.1.162-171.2005& earns monthly
- How much does https://doi.org/10.1089/ars.2010.3211 pull in monthly?
- https://scholar.google.com/scholar_lookup?journal=Antioxid%20Redox%20Signal&author=NF%20Villeneuve&author=A%20Lau&author=DD%20Zhang&volume=13&publication_year=2010&pages=1699-1712&pmid=20486766&doi=10.1089/ars.2010.3211&'s revenue stream
- How much does https://doi.org/10.1073/pnas.172398899 rake in every month?
- https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&author=AT%20Dinkova-Kostova&author=WD%20Holtzclaw&author=RN%20Cole&author=K%20Itoh&author=N%20Wakabayashi&volume=99&publication_year=2002&pages=11908-11913&pmid=12193649&doi=10.1073/pnas.172398899&'s total income per month
- How much money does https://doi.org/10.1128/MCB.23.22.8137-8151.2003 generate?
- What's the financial outcome of https://scholar.google.com/scholar_lookup?journal=Mol%20Cell%20Biol&author=DD%20Zhang&author=M%20Hannink&volume=23&publication_year=2003&pages=8137-8151&pmid=14585973&doi=10.1128/MCB.23.22.8137-8151.2003&?
- How much revenue does https://doi.org/10.1006/bbrc.1997.6943 bring in?
- What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Biochem%20Biophys%20Res%20Commun&author=K%20Itoh&author=T%20Chiba&author=S%20Takahashi&author=T%20Ishii&author=K%20Igarashi&volume=236&publication_year=1997&pages=313-322&pmid=9240432&doi=10.1006/bbrc.1997.6943&?
- What's the financial outcome of https://doi.org/10.1124/mol.109.058453?
- Profit of https://scholar.google.com/scholar_lookup?journal=Mol%20Pharmacol&author=X%20He&author=Q%20Ma&volume=76&publication_year=2009&pages=1265-1278&pmid=19786557&doi=10.1124/mol.109.058453&
- How much revenue does https://doi.org/10.1093/emboj/20.11.2835 generate?
- What's the income generated by https://scholar.google.com/scholar_lookup?journal=EMBO%20J&author=K%20Ogawa&author=J%20Sun&author=S%20Taketani&author=O%20Nakajima&author=C%20Nishitani&volume=20&publication_year=2001&pages=2835-2843&pmid=11387216&doi=10.1093/emboj/20.11.2835& each month?
- What is the earnings of https://doi.org/10.1016/j.freeradbiomed.2005.01.021?
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- Income figures for https://doi.org/10.1016/j.cell.2005.02.001
- How much income is https://scholar.google.com/scholar_lookup?journal=Cell&author=RS%20Balaban&author=S%20Nemoto&author=T%20Finkel&volume=120&publication_year=2005&pages=483-495&pmid=15734681&doi=10.1016/j.cell.2005.02.001& earning monthly?
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- Get to know what's the income of https://doi.org/10.1089/ars.2006.8.600
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- What's https://doi.org/10.1074/jbc.M401844200's gross income?
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- What's the income generated by https://doi.org/10.1073/pnas.0800691105 each month?
- How much does https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&author=M%20Gertz&author=F%20Fischer&author=D%20Wolters&author=C%20Steegborn&volume=105&publication_year=2008&pages=5705-5709&pmid=18413607&doi=10.1073/pnas.0800691105& bring in each month?
- https://doi.org/10.1083/jcb.200410041's financial summary
- How much does https://scholar.google.com/scholar_lookup?journal=J%20Cell%20Biol&author=WW%20Smith&author=DD%20Norton&author=M%20Gorospe&author=H%20Jiang&author=S%20Nemoto&volume=169&publication_year=2005&pages=331-339&pmid=15837797&doi=10.1083/jcb.200410041& rake in every month?
- https://doi.org/10.1074/jbc.M511626200's total income per month
- What's the financial outcome of https://scholar.google.com/scholar_lookup?journal=J%20Biol%20Chem&author=S%20Nemoto&author=CA%20Combs&author=S%20French&author=BH%20Ahn&author=MM%20Fergusson&volume=281&publication_year=2006&pages=10555-10560&pmid=16481327&doi=10.1074/jbc.M511626200&?
- How much income does https://doi.org/10.1126/science.1069004 have?
- What are the earnings of https://scholar.google.com/scholar_lookup?journal=Science&author=S%20Nemoto&author=T%20Finkel&volume=295&publication_year=2002&pages=2450-2452&pmid=11884717&doi=10.1126/science.1069004&?
- Financial intake of https://doi.org/10.1016/j.cell.2005.05.011
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