
NCBI . NLM . NIH . GOV {
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Title[redir]:
RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels - PMC
Description:
Therapeutics that discriminate between the genetic makeup of normal cells and tumour cells are valuable for treating and understanding cancer. Small molecules with oncogene-selective lethality may reveal novel functions of oncoproteins and enable ...
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Keywords {🔍}
erastin, vdac, cells, fig, doi, cell, supplementary, table, pubmed, google, scholar, death, mitochondrial, bjtertltstrasv, nihmssupplementtablesxls, xls, mitochondria, found, protein, nature, mechanism, braf, membrane, sensitivity, oxidative, cancer, kras, pmc, experiments, apoptosis, data, human, treatment, species, knockdown, performed, shrnas, analysis, vdacs, nadh, binding, nlm, tumour, lethality, rasrafmek, expressing, outer, compounds, erastininduced, western,
Topics {✒️}
kill bj-tert/lt/st/rasv12 cells bj-tert/lt/st/rasv12 cell lysates bj-tert/lt/st/rasv12 cells bj-tert/lt/st/rasv12 cells 24 bj-tert/lt/st/rasv12 mitochondria bj-tert/lt/st/rasv12 09 bj-tert/lt/st/rasv12 bj-tert/lt/st cells activated ras–raf–mek signalling table s10 nihms274480-supplement-table_s10 table s11 nihms274480-supplement-table_s11 table s12 nihms274480-supplement-table_s12 table s13 nihms274480-supplement-table_s13 table s14 nihms274480-supplement-table_s14 table s7 nihms274480-supplement-table_s7 table s8 nihms274480-supplement-table_s8 table s9 nihms274480-supplement-table_s9 ras–raf–mek signalling ras–raf–mek pathway mutant-kras-expressing cell lines bj-tert cell lysates bj-tert cell lysate bj-tert cells yielded discover oncogene-selective compounds oncogenic-hras-selective lethal compounds isogenic bj-tert cells half-maximal inhibitory concentration bj-derived cell series engineered bj-derived cells rna-interference-mediated knockdown prevent erastin-induced death /extracellular signal-regulated kinase hrasv12-expressing cell lines oncogenic ras signalling pmc beta search erastin-induced cell death mitogen-activated protein kinase genotype-selective antitumor agents tritium-labelled erastin a9 glucocorticoid-induced thymocyte apoptosis vdac2-targeted shrna plasmid bj-tert cells prevents erastin-induced lethality affinity-based target identification membrane-spanning channels oncogene-selective lethality multiple independent experiments phospho-erk western analysis cell death activated bj cell series
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