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We began analyzing https://biosignaling.biomedcentral.com/articles/10.1186/s12964-025-02121-2, but it redirected us to https://biosignaling.biomedcentral.com/articles/10.1186/s12964-025-02121-2. The analysis below is for the second page.

Title[redir]:
From mechanisms to medicine: Ferroptosis as a Therapeutic target in liver disorders | Cell Communication and Signaling | Full Text
Description:
In recent 10 years, ferroptosis has become a hot research direction in the scientific research community as a new way of cell death. Iron toxicity accumulation and lipotoxicity are unique features. Several studies have found that ferroptosis is involved in the regulation of the hepatic microenvironment and various hepatic metabolisms, thereby mediating the progression of related liver diseases. For example, NRF2 and FSP1, as important regulatory proteins of ferroptosis, are involved in the development of liver tumors and liver failure. In this manuscript, we present the mechanisms involved in ferroptosis, the concern of ferroptosis with the liver microenvironment and the progression of ferroptosis in various liver diseases. In addition, we summarize recent clinical advances in targeted ferroptosis therapy for related diseases. We expect that this manuscript can provide a new perspective for clinical treatment of related diseases.

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Keywords {🔍}

ferroptosis, pubmed, google, scholar, article, cas, liver, cell, iron, central, cells, hepatic, death, disease, lipid, cancer, injury, role, wang, metabolism, diseases, gpx, biol, research, mechanisms, damage, accumulation, treatment, peroxidation, mitochondrial, fatty, acsl, pathway, signaling, hepatocellular, cellular, metabolic, sorafenib, acid, apoptosis, expression, inhibiting, zhang, liu, carcinoma, therapeutic, nrf, ros, axis, oxidative,

Topics {✒️}

anti-pd-l1 antibodies activate rna-binding protein elavl1/hur sa-β-gal positive cells p62-keap1-nrf2 signaling cascade p62-keap1-nrf2 pathway protects cystine-glutamate antiporter xct hepatic ischemia/reperfusion injury hepatic ischemia-reperfusion injury regulating alox15/inos-mediated ferroptosis goa/mir-targeted nanocomposites caffeic acid-fibronectin mimic cerebral ischemia–reperfusion injury drug-induced liver injury activated portal fibroblasts/myofibroblasts gut-liver-brain axis liver-adipose tissue axis trx-cbi showed cytotoxicity drug-induced hepatic injuries p62-keap1-nrf2 path sensitize anti-pd-1 immunotherapy hematopoietic stem cell exercise-induced inflammatory responses perk-dependent mams formation anti-oxidative stress elements bmp-smad signaling pathway cdgsh iron-sulfur domain system xc−/gpx4 axis activates anti-tumor immunity long-term ethanol exposure acyl-coa ligase 4 clinical trial-stage candidates alcohol-induced oxidative stress mouse liver-specific gene phosphatidylinositol-3-kinase/protein kinase tf-fe3+-trr complex iron-induced cell death stress-induced oxidation signaling cell-line selectivity improves alcohol-induced cell death additional information publisher defective ncoa4-dependent ferroptosis erastin-induced iron ptosis ethanol-induced hepatic ferroptosis repressing nf-κb polyunsaturated fatty acids gut microbiota activates ampk/mtor signaling pathway key anti-ferroptotic components gsh-related amino acids xc− cystine transporter

Questions {❓}

Autophagy in cell death: an innocent convict?
Building upon the preceding discourse, several queries and contemplations emerge: (I) At what juncture or stage should the ferroptosis process in specific pathological liver diseases be targeted for intervention?
In probing the mechanisms of ferroptosis within the hepatic microenvironment, we question whether such mitochondrial anomalies are a driving force or simply a corollary of ferroptosis?
Neurological disorder and psychosocial aspects of cerebral malaria: what is new on its pathogenesis and complications?
The emerging role of ferroptosis in non-cancer liver diseases: hype or increasing hope?
Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

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