
NCBI . NLM . NIH . GOV {
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Title[redir]:
HSPB1 as a Novel Regulator of Ferroptotic Cancer Cell Death - PMC
Description:
Ferroptosis is an iron-dependent form of non-apoptotic cell death, but its molecular mechanism remains largely unknown. Here, we demonstrate that heat shock protein beta-1 (HSPB1) is a negative regulator of ferroptotic cancer cell death. Erastin, a ...
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Keywords {๐}
doi, hspb, cell, cells, ferroptosis, erastin, pubmed, google, scholar, erastininduced, death, fig, cancer, hsp, iron, heat, hela, shock, expression, inhibition, pmc, hsf, protein, article, phosphorylation, free, human, growth, lipid, hours, knockdown, increased, activity, ros, usa, biol, uos, control, group, tumor, treatment, analysis, shrna, versus, assay, role, effects, stress, proteins, hsps,
Topics {โ๏ธ}
oncogenic-ras-harboring cancer cells cgmp-dependent protein kinase real-time rt-pcr heat-induced hsp expression sds-polyacrylamide gel electrophoresis gel-pro analyzerยฎ software ras-carrying cancer cells wiskott-aldrich syndrome protein genotype-selective antitumor agents erastin-induced growth inhibition inhibit erastin-induced ferroptosis enhances erastin-induced ferroptosis erastin-mediated anticancer therapy erastin-induced intracellular iron preventing erastin-induced accumulation pmc beta search delta-mediated cell death small heat-shock proteins suppress erastin-induced ferroptosis hsf1-dependent hspb1 expression erastin-induced hspb1 expression bravo-san pedro jm reducing iron-mediated production ferroptosis-mediated cancer therapy acute renal failure universal pro-survival event specific ferroptosis-inducing compound erastin-induced hspb1 phosphorylation hspb1 phosphorylation-mediated resistance wild-type hspb1 cdna wasp-wave protein network significant heat-shock response hsp27 phosphorylation-mediated resistance oxidative lethal mechanism cystine/glutamate antiporters peroxidase-conjugated secondary antibodies heat shock pretreatment pkc-mediated hspb1 phosphorylation pcdna4-hismaxc-s15a/s86a increased growth inhibition quantitative rt-pcr 18s ribosomal rna reactive oxygen species dependent hspb1 expression chaperone activity- dependent increased tumor sensitivity iron-dependent accumulation iron-dependent enzymes cell death induced nat rev cancer
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- Small heat-shock proteins and clusterin: intra- and extracellular molecular chaperones with a common mechanism of action and function?
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Analytics and Tracking {๐}
- Google Analytics
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Libraries {๐}
- Foundation
- jQuery
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- Zoom.js
Emails and Hosting {โ๏ธ}
Mail Servers:
- nihcesxway.hub.nih.gov
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Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
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- lhcns1.nlm.nih.gov
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CDN Services {๐ฆ}
- Ncbi