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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

doi, complex, ferroptosis, dhodh, pubmed, google, scholar, mitochondrial, effect, iii, cell, biosynthesis, inhibition, pmc, warburg, article, cells, free, cancer, role, study, pyrimidine, tumor, nucleotide, growth, novo, gpx, ros, generation, oxidative, induction, reaction, hifα, dehydrogenase, cellular, glycolysis, aspartate, suggests, tumors, gsh, electron, mechanism, membrane, mitochondria, metabolic, biochemical, result, stress, dihydroorotate, inhibit,

Topics {✒️}

glutamate–oxaloacetate transaminase 1 glutamate–oxaloacetate transaminase 2 thymidine monophosphate acute myeloid leukemia deoxynucleosides triphosphates uridine monophosphate nucleosides triphosphates ribonucleotide reductase oxygen-dependent degradation domain deoxyribonucleic acid glutathione-independent ferroptosis suppressor oxygen consumption rate reduced glutathione hif-1 alpha voltage-dependent anion channels 2 mitochondrial oxygen consumption got2-dependent aspartate biosynthesis pten-induced kinase 1 cystine-glutamate antiporter fadh2 e1 aml aox mdh2 tmp dtmp slc1a3 fsp1 nadph oxidase hif prolyl-hydroxylases m2 isoform hypoxia-inducible factor-1 activation m2-pk caused isocitrate dehydrogenase pyruvate kinase m2 m2-pk generate adenosine triphosphate reduced fumarate hydratase loss nucleoside triphosphates nucleoside triphosphates mtdna oxygen-sensitive hif-1α subunit acute high concentrations got2 mobile electron carrier fumarate hydratase succinate dehydrogenase nad ocr

Questions {❓}

• Curbing cancer's sweet tooth: is there a role for MnSOD in regulation of the Warburg effect?
• Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
• The Warburg effect: how does it benefit cancer cells?
• The question now arises: between oxidative stress and the inhibition of complex I activity, which of the two plays the most important role in the induction of aerobic glycolysis?

Social Networks {👍}(6)

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• https://twitter.com/nlm_nih
• https://www.facebook.com/nationallibraryofmedicine
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• https://doi.org/10.1146/annurev-bioeng-071516-044546 income
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• What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Biophys%20J&title=Redox-driven%20proton%20pumps%20of%20the%20respiratory%20chain&author=AA%20Stuchebrukhov&volume=115&issue=5&publication_year=2018&pages=830-840&pmid=30119834&doi=10.1016/j.bpj.2018.07.022&?
• How much revenue does https://doi.org/10.1016/j.chembiol.2018.03.005 bring in?
• What's the revenue for https://scholar.google.com/scholar_lookup?journal=Cell%20Chem%20Biol&title=Dependence%20on%20the%20pyrimidine%20biosynthetic%20enzyme%20DHODH%20is%20a%20synthetic%20lethal%20vulnerability%20in%20mutant%20KRAS-driven%20cancers&author=M%20Koundinya&author=J%20Sudhalter&author=A%20Courjaud&author=B%20Lionne&author=G%20Touyer&volume=25&issue=6&publication_year=2018&pages=705&pmid=29628435&doi=10.1016/j.chembiol.2018.03.005&?
• What's the monthly money flow for https://doi.org/10.1016/j.celrep.2018.05.060?
• How much money does https://scholar.google.com/scholar_lookup?journal=Cell%20Rep&title=Energy%20metabolism%20rewiring%20precedes%20UVB-induced%20primary%20skin%20tumor%20formation&author=M%20Hosseini&author=L%20Dousset&author=W%20Mahfouf&author=M%20Serrano-Sanchez&author=I%20Redonnet-Vernhet&volume=23&issue=12&publication_year=2018&pages=3621-3634&pmid=29925003&doi=10.1016/j.celrep.2018.05.060& generate?
• https://doi.org/10.1155/2012/161837 income
• Income figures for https://scholar.google.com/scholar_lookup?journal=Int%20J%20Cell%20Biol&title=TCA%20cycle%20defects%20and%20cancer:%20when%20metabolism%20tunes%20redox%20state&author=S%20Cardaci&author=MR%20Ciriolo&volume=2012&publication_year=2012&pages=161837&pmid=22888353&doi=10.1155/2012/161837&
• What are the total earnings of https://doi.org/10.1016/j.ymben.2016.11.005?
• Get to know https://scholar.google.com/scholar_lookup?journal=Metab%20Eng&title=Dual%20loss%20of%20succinate%20dehydrogenase%20(SDH)%20and%20complex%20I%20activity%20is%20necessary%20to%20recapitulate%20the%20metabolic%20phenotype%20of%20SDH%20mutant%20tumors&author=D%20Lorendeau&author=G%20Rinaldi&author=R%20Boon&author=P%20Spincemaille&author=K%20Metzger&volume=43&publication_year=2017&pages=187-197&pmid=27847310&doi=10.1016/j.ymben.2016.11.005&'s earnings
• What is the monthly revenue of https://doi.org/10.1016/j.celrep.2017.09.092?
• How much profit does https://scholar.google.com/scholar_lookup?journal=Cell%20Rep&title=Fumarate%20hydratase%20loss%20causes%20combined%20respiratory%20chain%20defects&author=PA%20Tyrakis&author=ME%20Yurkovich&author=M%20Sciacovelli&author=EK%20Papachristou&author=HR%20Bridges&volume=21&issue=4&publication_year=2017&pages=1036-1047&pmid=29069586&doi=10.1016/j.celrep.2017.09.092& generate?
• How much revenue does https://doi.org/10.1016/j.mehy.2009.12.029 bring in?
• How much income is https://scholar.google.com/scholar_lookup?journal=Med%20Hypotheses&title=Oxidative%20stress%20therapy%20for%20solid%20tumors%E2%80%93a%20proposal&author=MF%20McCarty&author=J%20Barroso-Aranda&author=F%20Contreras&volume=74&issue=6&publication_year=2010&pages=1052-1054&pmid=20089364&doi=10.1016/j.mehy.2009.12.029& earning monthly?
• Discover the revenue of https://doi.org/10.1080/01635581.2015.1085584
• How much does https://scholar.google.com/scholar_lookup?journal=Nutr%20Cancer&title=The%20effect%20of%20silencing%20HIF-1%CE%B1%20gene%20in%20BxPC-3%20cell%20line%20on%20glycolysis-related%20gene%20expression,%20cell%20growth,%20invasion,%20and%20apoptosis&author=Y%20Jiang&author=GH%20Wu&author=GD%20He&author=QL%20Zhuang&author=QL%20Xi&volume=67&issue=8&publication_year=2015&pages=1314-1323&pmid=26576476&doi=10.1080/01635581.2015.1085584& rake in every month?
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• How much profit does https://scholar.google.com/scholar_lookup?journal=J%20Mol%20Biol&title=HIF-1%20alpha%20hydroxyprolines%20modulate%20oxygen-dependent%20protein%20stability%20via%20single%20VHL%20interface%20with%20comparable%20effect%20on%20ubiquitination%20rate&author=WG%20He&author=S%20Batty-Stuart&author=JE%20Lee&author=M%20Ohh&volume=433&issue=22&publication_year=2021&pages=17&pmid=34537235&doi=10.1016/j.jmb.2021.167244& generate?
• How much does https://doi.org/10.1091/mbc.e10-01-0025 generate monthly?
• https://scholar.google.com/scholar_lookup?journal=Mol%20Biol%20Cell&title=Hypoxia-inducible%20factor-1%20activation%20in%20nonhypoxic%20conditions:%20the%20essential%20role%20of%20mitochondrial-derived%20reactive%20oxygen%20species&author=DA%20Patten&author=VN%20Lafleur&author=GA%20Robitaille&author=DA%20Chan&author=AJ%20Giaccia&volume=21&issue=18&publication_year=2010&pages=3247-3257&pmid=20660157&doi=10.1091/mbc.e10-01-0025&'s total income per month
• https://doi.org/10.1186/1476-4598-8-32's financial summary
• How much money does https://scholar.google.com/scholar_lookup?journal=Mol%20Cancer&title=The%20role%20of%20cellular%20oxidative%20stress%20in%20regulating%20glycolysis%20energy%20metabolism%20in%20hepatoma%20cells&author=DY%20Shi&author=FZ%20Xie&author=C%20Zhai&author=JS%20Stern&author=Y%20Liu&volume=8&issue=1&publication_year=2009&pages=1-5&pmid=19497135&doi=10.1186/1476-4598-8-32& generate?
• How much does https://doi.org/10.1016/j.febslet.2005.03.088 pull in?
• See how much https://scholar.google.com/scholar_lookup?journal=FEBS%20Lett&title=A%20targeted%20antioxidant%20reveals%20the%20importance%20of%20mitochondrial%20reactive%20oxygen%20species%20in%20the%20hypoxic%20signaling%20of%20HIF-1%20alpha&author=A%20Sanjuan-Pla&author=AM%20Cervera&author=N%20Apostolova&author=R%20Garcia-Bou&author=VM%20Victor&volume=579&issue=12&publication_year=2005&pages=2669-2674&pmid=15862307&doi=10.1016/j.febslet.2005.03.088& makes per month
• How much profit is https://doi.org/10.1158/0008-5472.CAN-15-3079 making per month?
• Income figures for https://scholar.google.com/scholar_lookup?journal=Can%20Res&title=PINK1%20is%20a%20negative%20regulator%20of%20growth%20and%20the%20Warburg%20effect%20in%20glioblastoma&author=S%20Agnihotri&author=B%20Golbourn&author=X%20Huang&author=M%20Remke&author=S%20Younger&volume=76&issue=16&publication_year=2016&pages=4708-4719&pmid=27325644&doi=10.1158/0008-5472.CAN-15-3079&
• How much money does https://doi.org/10.3389/fonc.2020.00159 make?
• How much does https://scholar.google.com/scholar_lookup?journal=Front%20Oncol&title=Pyruvate%20kinase%20M2%20and%20cancer:%20the%20role%20of%20PKM2%20in%20promoting%20tumorigenesis&author=K%20Zahra&author=T%20Dey&author=Mishra%20SP%20Ashish&author=U%20Pandey&volume=10&publication_year=2020&pages=159&pmid=32195169&doi=10.3389/fonc.2020.00159& earn?
• What's the income generated by https://doi.org/10.1126/science.1249161 each month?
• See how much https://scholar.google.com/scholar_lookup?journal=Science&title=PINK1%20loss-of-function%20mutations%20affect%20mitochondrial%20complex%20I%20activity%20via%20NdufA10%20ubiquinone%20uncoupling&author=VA%20Morais&author=D%20Haddad&author=K%20Craessaerts&author=PJ%20De%20Bock&author=J%20Swerts&volume=344&issue=6180&publication_year=2014&pages=203-207&pmid=24652937&doi=10.1126/science.1249161& makes per month
• https://doi.org/10.1016/j.bbabio.2016.03.031's total income per month
• How much income does https://scholar.google.com/scholar_lookup?journal=Biochimica%20et%20Biophysica%20Acta%20(BBA)%20Bioenergetics&title=Unraveling%20the%20complexity%20of%20mitochondrial%20complex%20I%20assembly:%20a%20dynamic%20process&author=L%20S%C3%A1nchez-Caballero&author=S%20Guerrero-Castillo&author=L%20Nijtmans&volume=1857&issue=7&publication_year=2016&pages=980-990&pmid=27040506&doi=10.1016/j.bbabio.2016.03.031& have?
• What's the income generated by https://doi.org/10.1038/onc.2014.355 each month?
• https://scholar.google.com/scholar_lookup?journal=Oncogene&title=Manganese%20superoxide%20dismutase%20deficiency%20triggers%20mitochondrial%20uncoupling%20and%20the%20Warburg%20effect&author=Y%20Xu&author=S%20Miriyala&author=F%20Fang&author=V%20Bakthavatchalu&author=T%20Noel&volume=34&issue=32&publication_year=2015&pages=4229-4237&pmid=25362851&doi=10.1038/onc.2014.355&'s financial summary
• Revenue of https://doi.org/10.1007/s10147-017-1156-4
• How much revenue does https://scholar.google.com/scholar_lookup?journal=Int%20J%20Clin%20Oncol&title=Targeting%20metabolic%20reprogramming%20in%20KRAS-driven%20cancers&author=K%20Kawada&author=K%20Toda&author=Y%20Sakai&volume=22&issue=4&publication_year=2017&pages=651-659&pmid=28647837&doi=10.1007/s10147-017-1156-4& bring in?
• How much cash flow does https://doi.org/10.1038/s41419-021-03998-w have monthly?
• What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Cell%20Death%20Dis&title=Sorafenib%20fails%20to%20trigger%20ferroptosis%20across%20a%20wide%20range%20of%20cancer%20cell%20lines&author=J%20Zheng&author=M%20Sato&author=E%20Mishima&author=H%20Sato&author=B%20Proneth&volume=12&issue=7&publication_year=2021&pages=698&pmid=34257282&doi=10.1038/s41419-021-03998-w&?
• How much profit does https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Phase%20I%20clinical%20and%20pharmacokinetic%20trial%20of%20Brequinar%20sodium%20(DuP%20785;%20NSC%20368390)&author=CL%20Arteaga&author=TD%20Brown&author=JG%20Kuhn&author=HS%20Shen&author=TJ%20O'Rourke&volume=49&issue=16&publication_year=1989&pages=4648-4653&pmid=2743343& generate?
• What's the total monthly financial gain of https://doi.org/10.1080/15257770.2018.1508692?
• https://scholar.google.com/scholar_lookup?journal=Nucleosides%20Nucleotides%20Nucleic%20Acids&title=Re-evaluation%20of%20Brequinar%20sodium,%20a%20dihydroorotate%20dehydrogenase%20inhibitor&author=GJ%20Peters&volume=37&issue=12&publication_year=2018&pages=666-678&pmid=30663496&doi=10.1080/15257770.2018.1508692&'s financial summary
• What is the monthly revenue of https://github.com/ncbi?
• What's the profit of https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323?
• How much revenue does https://www.nlm.nih.gov/web_policies.html generate?
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• Income figures for https://www.nlm.nih.gov/accessibility.html
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• What's the financial intake of https://www.nlm.nih.gov/?
• How much does https://www.nih.gov/ pull in monthly?
• Get to know https://www.hhs.gov/'s earnings
• What's the monthly money flow for https://www.usa.gov/?

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