
NCBI . NLM . NIH . GOV {
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Title[redir]:
Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis - PMC
Description:
Ferroptosis plays a role in several diseases such as iron overload-induced liver diseases. Manipulation of ferroptosis has been explored as a potential therapeutic strategy to treat related diseases. Numerous antioxidants have been identified to ...
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Keywords {🔍}
iron, fgf, ferroptosis, doi, hepatocytes, fig, liver, expression, pubmed, google, scholar, primary, overload, mice, overloadinduced, protein, cell, levels, pmc, article, free, ros, treatment, cells, fibrosis, stress, overexpression, nrf, oxidative, death, results, factor, injury, lipid, dextran, control, found, gsh, level, mrna, diseases, lip, increased, growth, fac, role, recombinant, peroxidation, hepatic, treated,
Topics {✒️}
labile iron pool high-dose ferric citrate flag-tagged ubiquitin cdna vector plvx-dsred-monomer-n1 d-galactose-induced oxidative stress transferrin receptor 1 glutathione-independent ferroptosis suppressor iron-mediated ferroptosis-related disease glutathione peroxidase 4 polarised light microscope plasmids expressing ub-flag pi3k-akt-mtor signaling pathway aspartate transaminase iron overload-induced decrease ox-ldl-induced pyroptosis hepatic pro-fibrogenic genes iron overload-induced ferroptosis iron overload-induced ros iron-related pathological processes pmc beta search endocrine member fac-induced mitochondria damage goat anti-mouse antibodies redox-metal-induced formation iron metabolism-related genes transferrin-bound iron transferrin bound iron fgf family antioxidant capacity c57bl/6j male mice c57/bl6 male mice nuclear factor-kappab ha-tagged ho-1 protein ha-tagged ho-1 cdna fgf2-mediated ho-1 degradation ferroptosis-related gene ptgs2 fgf21-knockdown primary hepatocytes heme oxygenase-1 iron-dextran injected mice iron dextran-injected mice fibroblast growth factor fgf21-induced ho-1 inhibition ferroptosis-related gene ptsg2 fgf21-mediated ho-1 inhibition tet2-uqcrc1-ros pathway 200 ng/ml recombinant fgf21 free iron content ub-flag iron overload increases tibc
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