
NCBI . NLM . NIH . GOV {
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Title[redir]:
DHODH-mediated ferroptosis defense is a targetable vulnerability in cancer - PMC
Description:
Ferroptosis, a form of regulated cell death induced by excessive lipid peroxidation, has recently emerged as a key tumor suppression mechanism1–4. Glutathione peroxidase 4 (GPX4)5, 6 and ferroptosis suppressor protein 1 (FSP1)7, 8 constitute two ...
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Keywords {🔍}
cells, cell, dhodh, hours, data, ferroptosis, fig, measurement, gpx, lipid, extended, cancer, peroxidation, mitochondrial, treated, treatment, rsl, levels, doi, vehicle, pubmed, google, scholar, dhodhko, pmc, lip, casctrl, article, bqr, free, viability, pretreatment, ncih, analysis, protein, coq, uridine, doses, xlsx, lines, western, brequinar, performed, fsp, tumors, tumor, gpxlow, coqh, dho, deletion,
Topics {✒️}
apoptosis inhibitor z-vad-fmk n-benzyloxycarbonyl-val-ala-asp foxo-bnip3 axis exerts cystine transporter slc7a11/xct serum-free culture medium 1779371_sup_information nihms1779371-supplement-1779371_sup_information 1779371_peer_review_file nihms1779371-supplement-1779371_peer_review_file 1779371_reportingsummary nihms1779371-supplement-1779371_reportingsummary 1779371_sd_fig_1 nihms1779371-supplement-1779371_sd_fig_1 1779371_sd_fig_2 nihms1779371-supplement-1779371_sd_fig_2 1779371_sd_fig_3 nihms1779371-supplement-1779371_sd_fig_3 1779371_sd_fig_4 nihms1779371-supplement-1779371_sd_fig_4 1779371_sd_ed_fig_1 nihms1779371-supplement-1779371_sd_ed_fig_1 1779371_sd_ed_fig_2 nihms1779371-supplement-1779371_sd_ed_fig_2 1779371_sd_ed_fig_3 nihms1779371-supplement-1779371_sd_ed_fig_3 1779371_sd_ed_fig_4 nihms1779371-supplement-1779371_sd_ed_fig_4 1779371_sd_ed_fig_5 nihms1779371-supplement-1779371_sd_ed_fig_5 1779371_sd_ed_fig_6 nihms1779371-supplement-1779371_sd_ed_fig_6 1779371_sd_ed_fig_7 nihms1779371-supplement-1779371_sd_ed_fig_7 1779371_sd_ed_fig_8 nihms1779371-supplement-1779371_sd_ed_fig_8 1779371_sd_ed_fig_9 nihms1779371-supplement-1779371_sd_ed_fig_9 maintain long-term culturing high-resolution-multiple-tracer-data dana-farber cancer institute advanced squamous-cell carcinoma tsc-mtor signaling pathways pmc beta search nci-h226 xenograft tumors remove serum-derived coq lipophilic radical-trapping antioxidant gpx4low nci-h226 xenografts gpx4low patient-derived xenografts nci-h226 cells rendered ml162-induced lipid peroxidation gpx4low nci-h226 cells eppendorf tubes pre-chilled dhodhko nci-h226 cells feed complex iii 100 μm tert-butyl-hydroquinone cold phosphate-buffered saline coq/coqh2 ratio measurement n-carbamoyl-l-aspartate lentivirus vector plvx-puro pi3k-akt pathway presumed anti-ferroptosis function p53-mediated activity renal tumor growth lipid metabolism enzyme ratiometric fluorescent probe lncrna nbr2 engages
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