
NCBI . NLM . NIH . GOV {
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Title[redir]:
Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms - PMC
Description:
Iron homeostasis is essential for health; moreover, hepcidin-deficiency results in iron overload in both hereditary hemochromatosis and iron-loading anemia. Here, we identified iron modulators by functionally screening hepcidin agonists using a ...
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Keywords {🔍}
aur, doi, hepcidin, iron, mice, expression, fig, cells, pubmed, google, scholar, mrna, ferroptosis, hepatic, hfe, pmc, article, huh, levels, cell, free, male, found, treatment, effect, measured, treated, female, hamp, mgkg, significantly, supplementary, data, highdose, txnrd, metabolism, serum, activity, inhibitor, pathway, liver, drug, thioredoxin, increased, body, blood, auranofin, drugs, signaling, estrogen,
Topics {✒️}
nf-κb/il-6/stat3 signaling pathway 5 mg/kg body weight/day apoptosis inhibitor z-vad-fmk specific pathogen-free facility high-dose aur‒induced decrease fda-approved anti-rheumatoid arthritis nf-κb/il-6/stat3 axis hepcidin-deficiency related disorders mapk/erk signaling pathway 5 mg/kg body weight 25 mg/kg body weight 1 mg/kg body weight 10 mg/kg body weight kaplan–meier survival curves author contributions pmc beta search gold-induced aplastic anemia high-dose aur showed treating iron-related diseases nf-κb inhibitor bay11–7082 high-dose aur increased induce il-6/hepcidin signaling gpr30-bmp6-dependent signaling tumor necrosis factor-alpha bmp6/bmp receptor complex tfr2/hfe complex triggers prevent hydroperoxide-induced ferroptosis recently identified iron-dependent long-term aur treatment license information pmcid myd88-dependent il-6 production transferrin-induced hepcidin expression nf-κb/il-6 pathway downstream pro-inflammatory cytokines perls’ prussian blue hepatic tnf-α expression high doses—inducing ferroptosis bmp/smad/hepcidin axis increased phospho-stat3 levels splenic tnf-α expression male c57bl/6j mice hepcidin-deficient mouse model female wild-type c57bl/6 master iron-regulating hormone lipid peroxidation-dependent form aur-regulated iron parameters iron-overload murine models il-1β mrna levels anti-ra drug auranofin canonical hepcidin-regulating pathways
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