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We began analyzing https://www.nature.com/articles/s41392-023-01452-1, but it redirected us to https://www.nature.com/articles/s41392-023-01452-1. The analysis below is for the second page.

Title[redir]:
Macrophages in immunoregulation and therapeutics | Signal Transduction and Targeted Therapy
Description:
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and cancers. Macrophages possess binary M1/M2 macrophage polarization settings, which perform a central role in an array of immune tasks via intrinsic signal cascades and, therefore, must be precisely regulated. Many crucial questions about macrophage signaling and immune modulation are yet to be uncovered. In addition, the clinical importance of tumor-associated macrophages is becoming more widely recognized as significant progress has been made in understanding their biology. Moreover, they are an integral part of the tumor microenvironment, playing a part in the regulation of a wide variety of processes including angiogenesis, extracellular matrix transformation, cancer cell proliferation, metastasis, immunosuppression, and resistance to chemotherapeutic and checkpoint blockade immunotherapies. Herein, we discuss immune regulation in macrophage polarization and signaling, mechanical stresses and modulation, metabolic signaling pathways, mitochondrial and transcriptional, and epigenetic regulation. Furthermore, we have broadly extended the understanding of macrophages in extracellular traps and the essential roles of autophagy and aging in regulating macrophage functions. Moreover, we discussed recent advances in macrophages-mediated immune regulation of autoimmune diseases and tumorigenesis. Lastly, we discussed targeted macrophage therapy to portray prospective targets for therapeutic strategies in health and diseases.

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Keywords {🔍}

pubmed, macrophages, article, google, scholar, cas, macrophage, central, cells, cancer, cell, tumor, immune, polarization, tams, activation, inflammatory, signaling, expression, immunol, response, inflammation, role, factor, regulation, metabolic, tissue, factors, gene, tumorassociated, responses, transcription, front, growth, disease, human, phenotype, essential, function, therapy, cytokines, proinflammatory, metastasis, therapeutic, infection, stat, pathway, activity, including, immunity,

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nature portfolio targeting fto/m6a/angptl4/integrin axis privacy policy professional antigen-presenting cells widespread regional lymphadenopathy scientific statement shrink-film multi-scale wrinkles advertising metabolic/lipid-engineered/amino acid pathways β-catenin/erk/akt signaling peroxisome proliferator-activated receptor-gamma sars-cov-2-infected rhesus macaques stimulate sa-β-gal expression cell-impermeable dna-staining dye critical tgf-β/mir-182/tlr4 axis p21-related anti-apoptotic pathways granulocyte-macrophage colony-stimulating factor cytokine-provoking pro-inflammatory responses β-catenin/stat3 signaling pathway folate receptor-β-targeted car pi3k-4ebp1-sox2 signaling pathway m-csf-formed m-bmm cancer-produced β-glucosylceramide drives target ikk/iкb/nf-кb sars-cov-2 spike protein csf1/csf1r-cxcl12/cxcr4 axis cad cis-aconitate decarboxylase activating β-catenin/stat3 signaling c-maf-mediated gene control macrophage-mediated t-cell inhibition single-cell transcriptomic data suppresses nf-κb-driven inflammation fast media dye wnt/β-catenin pathway reprints tumor-supportive anti-inflammatory cytokines control inter-cellular communication ha-pei/pdna-il-4 nps receptor-mediated nf-kappab activation pma-differentiated thp-1 cells anti-tumor t-cell response macrophage-specific klf2-knockout mice triple-negative breast cancer stretch-activated ion channels cd24-siglec-10 axis suppresses oxidized low-density lipoproteins peroxisome proliferator-activated receptors multi-omics signatures related serine/threonine kinase ulk1 aspartate-arginosuccinate shunt pathway

Questions {❓}

Convenience versus biological significance: are PMA-differentiated THP-1 cells a reliable substitute for blood-derived macrophages when studying in vitro polarization?
Inflammation and cancer: back to Virchow?
Metabolic alterations in aging macrophages: ingredients for inflammaging?
Monocytes, macrophages, and their potential niches in synovial joints - therapeutic targets in post-traumatic osteoarthritis?
Nanoparticles to target and treat macrophages: the Ockham’s concept?
Senescent cells and macrophages: key players for regeneration?
The role of notch signaling in macrophages during inflammation and infection: implication in rheumatoid arthritis?
Tumor associated macrophages, as the dominant immune cells, are an indispensable target for immunologically cold tumor-glioma therapy?

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