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Questions {❓}

• Convenience versus biological significance: are PMA-differentiated THP-1 cells a reliable substitute for blood-derived macrophages when studying in vitro polarization?
• Inflammation and cancer: back to Virchow?
• Metabolic alterations in aging macrophages: ingredients for inflammaging?
• Monocytes, macrophages, and their potential niches in synovial joints - therapeutic targets in post-traumatic osteoarthritis?
• Nanoparticles to target and treat macrophages: the Ockham’s concept?
• Senescent cells and macrophages: key players for regeneration?
• The role of notch signaling in macrophages during inflammation and infection: implication in rheumatoid arthritis?
• Tumor associated macrophages, as the dominant immune cells, are an indispensable target for immunologically cold tumor-glioma therapy?

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