We are analyzing https://link.springer.com/article/10.1186/s40364-021-00333-5.

Title:
Landscape of Myeloid-derived Suppressor Cell in Tumor Immunotherapy | Biomarker Research
Description:
Myeloid-derived suppressor cells (MDSC) are a group of immature cells that produced by emergency myelopoiesis. Emerging evidences have identified the vital role of MDSC in cancer microenvironment, in which MDSC exerts both immunological and non-immunological activities to assist the progression of cancer. Advances in pre-clinical research have provided us the understanding of MDSC in cancer context from the perspective of molecular mechanism. In clinical scenario, MDSC and its subsets have been discovered to exist in peripheral blood and tumor site of patients from various types of cancers. In this review, we highlight the clinical value of MDSC in predicting prognosis of cancer patients and the responses of immunotherapies, therefore to propose the MDSC-inhibiting strategy in the scenario of cancer immunotherapies. Phenotypes and biological functions of MDSC in cancer microenvironment are comprehensively summarized to provide potential targets of MDSC-inhibiting strategy from the aspect of molecular mechanisms.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

cancer, pubmed, mdsc, cells, article, google, scholar, cell, cas, suppressor, myeloidderived, central, tumor, patients, clinical, immunol, res, wang, metastasis, microenvironment, lung, immune, expression, carcinoma, immunotherapy, melanoma, response, zhang, promotes, myeloid, factor, signaling, breast, study, activity, reported, inhibitors, immunosuppressive, mmdsc, promote, cancers, treatment, therapy, peripheral, survival, cxcr, cxcl, including, blood, colorectal,

Topics {✒️}

circulating her2-reactive cd8 + t-cells platelet-derived growth factor-bb lin−hla-dr−cd33+ mdsc conducts epithelial-mesenchymal transition bone marrow-derived-pmn-mdscs t-cell-receptor signaling network myeloid-derived suppressor cells myeloid-derived suppressor cells tgf-beta-mtor-hif-1 signaling myeloid-derived suppressor cell s100a9-cd33-il-10/tgf-β axis hla-dr−cd33lowcd11b+cd3− mdsc early-life exposure tlr4-mediated nf-κb pathways csf2/p-stat3 signalling pathway tumor-derived prostaglandin-e2 blocks hla-dr− cd33+ cells cd11b+cd14+cd33+cxcr4+mdscs pi3k-akt-mtor pathway [102] granulocyte-derived hydrogen peroxide article download pdf reduced interferon-alpha signaling including driver-gene mutations cell-mediated antitumor effects myeloid derived suppressor nf-κb dependent manner nf-κb target genes myeloid-derived pmn-mdscs enhance bispecific antibody-driven human chromosome 7p15-p21 cancer-derived factors diffused granulocyte colony-stimulating factor enhancing t-cell responses single-dose cyclophosphamide associates hematopoietic stem cell anti-apoptotic factors mcl-1 kras-mutated colorectal cancer il-6r mab drug pro-metastatic factors mmp9 adoptive t-cell immunotherapy protein-coupled receptor family restricting mycobiota-mediated expansion ccl15/ccr1-dependent manner [20] t-cell activation events cell-mediated cytotoxicity attack anti-cd73 antibody administrations ccl15-ccr1 chemokine axis enhance anti-tumor immunoactivity cancer cell-derived pge2 inhibiting pro-inflammatory cells

Schema {🗺️}

WebPage:
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         headline:Landscape of Myeloid-derived Suppressor Cell in Tumor Immunotherapy
         description:Myeloid-derived suppressor cells (MDSC) are a group of immature cells that produced by emergency myelopoiesis. Emerging evidences have identified the vital role of MDSC in cancer microenvironment, in which MDSC exerts both immunological and non-immunological activities to assist the progression of cancer. Advances in pre-clinical research have provided us the understanding of MDSC in cancer context from the perspective of molecular mechanism. In clinical scenario, MDSC and its subsets have been discovered to exist in peripheral blood and tumor site of patients from various types of cancers. In this review, we highlight the clinical value of MDSC in predicting prognosis of cancer patients and the responses of immunotherapies, therefore to propose the MDSC-inhibiting strategy in the scenario of cancer immunotherapies. Phenotypes and biological functions of MDSC in cancer microenvironment are comprehensively summarized to provide potential targets of MDSC-inhibiting strategy from the aspect of molecular mechanisms.
         datePublished:2021-10-24T00:00:00Z
         dateModified:2022-02-07T00:00:00Z
         pageStart:1
         pageEnd:28
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            Tumor
            Immunotherapy
            Biomedicine
            general
            Cancer Research
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      headline:Landscape of Myeloid-derived Suppressor Cell in Tumor Immunotherapy
      description:Myeloid-derived suppressor cells (MDSC) are a group of immature cells that produced by emergency myelopoiesis. Emerging evidences have identified the vital role of MDSC in cancer microenvironment, in which MDSC exerts both immunological and non-immunological activities to assist the progression of cancer. Advances in pre-clinical research have provided us the understanding of MDSC in cancer context from the perspective of molecular mechanism. In clinical scenario, MDSC and its subsets have been discovered to exist in peripheral blood and tumor site of patients from various types of cancers. In this review, we highlight the clinical value of MDSC in predicting prognosis of cancer patients and the responses of immunotherapies, therefore to propose the MDSC-inhibiting strategy in the scenario of cancer immunotherapies. Phenotypes and biological functions of MDSC in cancer microenvironment are comprehensively summarized to provide potential targets of MDSC-inhibiting strategy from the aspect of molecular mechanisms.
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      dateModified:2022-02-07T00:00:00Z
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      pageEnd:28
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         Myeloid-derived suppressor cells
         Tumor
         Immunotherapy
         Biomedicine
         general
         Cancer Research
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                     type:PostalAddress
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                     name:Department of Gynecology and Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
                     type:PostalAddress
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            affiliation:
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                     type:PostalAddress
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                  name:Huazhong University of Science and Technology
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                     name:Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
                     type:PostalAddress
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               name:Department of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, China
               type:PostalAddress
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      name:Ruyuan Li
      affiliation:
            name:Huazhong University of Science and Technology
            address:
               name:Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
               type:PostalAddress
            type:Organization
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               name:Department of Gynecology and Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
               type:PostalAddress
            type:Organization
      name:Yuanyuan Wang
      affiliation:
            name:Huazhong University of Science and Technology
            address:
               name:Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
               type:PostalAddress
            type:Organization
      name:Shuangying Li
      affiliation:
            name:Huazhong University of Science and Technology
            address:
               name:Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
               type:PostalAddress
            type:Organization
      name:Zhenya Hong
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            name:Huazhong University of Science and Technology
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      email:[email protected]
PostalAddress:
      name:Department of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, China
      name:Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
      name:Department of Gynecology and Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
      name:Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
      name:Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
      name:Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
      name:Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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