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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s11523-020-00717-x.

Title:
MicroRNAs (miRNAs) and Long Non-Coding RNAs (lncRNAs) as New Tools for Cancer Therapy: First Steps from Bench to Bedside | Targeted Oncology
Description:
Non-coding RNAs represent a significant proportion of the human genome. After having been considered as ‘junk’ for a long time, non-coding RNAs are now well established as playing important roles in maintaining cellular homeostasis and functions. Some non-coding RNAs show cell- and tissue-specific expression patterns and are specifically deregulated under pathological conditions (e.g. cancer). Therefore, non-coding RNAs have been extensively studied as potential biomarkers in the context of different diseases with a focus on microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) for several years. Since their discovery, miRNAs have attracted more attention than lncRNAs in research studies; however, both families of non-coding RNAs have been established to play an important role in gene expression control, either as transcriptional or post-transcriptional regulators. Both miRNAs and lncRNAs can regulate key genes involved in the development of cancer, thus influencing tumour growth, invasion, and metastasis by increasing the activation of oncogenic pathways and limiting the expression of tumour suppressors. Furthermore, miRNAs and lncRNAs are also emerging as important mediators in drug-sensitivity and drug-resistance mechanisms. In the light of these premises, a number of pre-clinical and early clinical studies are exploring the potential of non-coding RNAs as new therapeutics. The aim of this review is to summarise the latest knowledge of the use of miRNAs and lncRNAs as therapeutic tools for cancer treatment.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

pubmed, article, google, scholar, cas, noncoding, cancer, rnas, central, long, rna, expression, mirnas, cell, mirna, lncrnas, patients, microrna, micrornas, cells, therapeutic, lncrna, nat, clinical, therapeutics, study, gene, delivery, res, tumour, small, targeting, phase, potential, development, target, wang, mol, zhang, biol, therapy, rev, diseases, effects, disease, targets, human, biomarkers, genes, pathways,

Topics {✒️}

large-scale clip-seq data article  google scholar mir-221/222-myod-myomirs regulatory pathway lncrna-rna-binding protein interactions genome-scale crispr-mediated control n-acetylgalactosamine conjugated anti-mirna crispri-based genome-scale identification n-acetylgalactosamine conjugated anti-mir-103/107 transforming growth factor-beta large-scale drug screening cutaneous t-cell lymphoma hypoxia-inducible factor 1-alpha exonuclease xrn2-dependent manner article download pdf nonmuscle-invasive bladder cancer hereditary transthyretin-mediated amyloidosis key tumor-suppressive pathways activation-induced cell death carrier-elicited inflammatory reaction lncrna pca3-based test van der veer van der valk h19-promoter-targeted therapy combined recurrent ovarian/peritoneal cancer mirna-mrna interactions occur functional microrna-mrna interactions interferon-α-based therapy [216 exhibits pro-oncogenic activity small-interfering rna drug liposomal mir-34a mimic efficient oligonucleotide-mediated degradation mirna biogenesis-related enzymes potentially trigger pro-inflammatory synthetic microrna-92a inhibitor chromatin signature reveals pi3k/akt survival pathways liposome-formulated mirna-34 mimic sirna-based strategies involving cell type-specific manner small rna-mediated regulation protein-rna interaction networks mirna-target messenger rna lna-modified oligonucleotide inhibitor triple-negative breast cancer c-myc urinary rna-based biomarkers early anti-tumour activity disease-specific mirna signatures anti-mir-10b construct vivo anti-hbv activity

Questions {❓}

  • Long non-coding RNAs: at the heart of cardiac dysfunction?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:MicroRNAs (miRNAs) and Long Non-Coding RNAs (lncRNAs) as New Tools for Cancer Therapy: First Steps from Bench to Bedside
         description:Non-coding RNAs represent a significant proportion of the human genome. After having been considered as ‘junk’ for a long time, non-coding RNAs are now well established as playing important roles in maintaining cellular homeostasis and functions. Some non-coding RNAs show cell- and tissue-specific expression patterns and are specifically deregulated under pathological conditions (e.g. cancer). Therefore, non-coding RNAs have been extensively studied as potential biomarkers in the context of different diseases with a focus on microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) for several years. Since their discovery, miRNAs have attracted more attention than lncRNAs in research studies; however, both families of non-coding RNAs have been established to play an important role in gene expression control, either as transcriptional or post-transcriptional regulators. Both miRNAs and lncRNAs can regulate key genes involved in the development of cancer, thus influencing tumour growth, invasion, and metastasis by increasing the activation of oncogenic pathways and limiting the expression of tumour suppressors. Furthermore, miRNAs and lncRNAs are also emerging as important mediators in drug-sensitivity and drug-resistance mechanisms. In the light of these premises, a number of pre-clinical and early clinical studies are exploring the potential of non-coding RNAs as new therapeutics. The aim of this review is to summarise the latest knowledge of the use of miRNAs and lncRNAs as therapeutic tools for cancer treatment.
         datePublished:2020-05-25T00:00:00Z
         dateModified:2020-05-25T00:00:00Z
         pageStart:261
         pageEnd:278
         license:http://creativecommons.org/licenses/by-nc/4.0/
         sameAs:https://doi.org/10.1007/s11523-020-00717-x
         keywords:
            Oncology
            Biomedicine
            general
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11523-020-00717-x/MediaObjects/11523_2020_717_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11523-020-00717-x/MediaObjects/11523_2020_717_Fig2_HTML.png
         isPartOf:
            name:Targeted Oncology
            issn:
               1776-260X
               1776-2596
            volumeNumber:15
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer International Publishing
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Margherita Ratti
               affiliation:
                     name:The Institute of Cancer Research
                     address:
                        name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
                        type:PostalAddress
                     type:Organization
                     name:The Institute of Cancer Research
                     address:
                        name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
                        type:PostalAddress
                     type:Organization
                     name:Ospedale di Cremona
                     address:
                        name:Medical Department, Division of Oncology, ASST di Cremona, Ospedale di Cremona, Cremona, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Andrea Lampis
               affiliation:
                     name:The Institute of Cancer Research
                     address:
                        name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
                        type:PostalAddress
                     type:Organization
                     name:The Institute of Cancer Research
                     address:
                        name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Michele Ghidini
               affiliation:
                     name:Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
                     address:
                        name:Division of Medical Oncology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Massimiliano Salati
               affiliation:
                     name:The Institute of Cancer Research
                     address:
                        name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
                        type:PostalAddress
                     type:Organization
                     name:The Institute of Cancer Research
                     address:
                        name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Milko B. Mirchev
               affiliation:
                     name:Medical University
                     address:
                        name:Clinic of Gastroenterology, Medical University, Varna, Bulgaria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Nicola Valeri
               affiliation:
                     name:The Institute of Cancer Research
                     address:
                        name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
                        type:PostalAddress
                     type:Organization
                     name:The Institute of Cancer Research
                     address:
                        name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
                        type:PostalAddress
                     type:Organization
                     name:The Royal Marsden NHS Foundation Trust
                     address:
                        name:Department of Medicine, The Royal Marsden NHS Foundation Trust, London, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jens C. Hahne
               url:http://orcid.org/0000-0002-1425-7486
               affiliation:
                     name:The Institute of Cancer Research
                     address:
                        name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
                        type:PostalAddress
                     type:Organization
                     name:The Institute of Cancer Research
                     address:
                        name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:MicroRNAs (miRNAs) and Long Non-Coding RNAs (lncRNAs) as New Tools for Cancer Therapy: First Steps from Bench to Bedside
      description:Non-coding RNAs represent a significant proportion of the human genome. After having been considered as ‘junk’ for a long time, non-coding RNAs are now well established as playing important roles in maintaining cellular homeostasis and functions. Some non-coding RNAs show cell- and tissue-specific expression patterns and are specifically deregulated under pathological conditions (e.g. cancer). Therefore, non-coding RNAs have been extensively studied as potential biomarkers in the context of different diseases with a focus on microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) for several years. Since their discovery, miRNAs have attracted more attention than lncRNAs in research studies; however, both families of non-coding RNAs have been established to play an important role in gene expression control, either as transcriptional or post-transcriptional regulators. Both miRNAs and lncRNAs can regulate key genes involved in the development of cancer, thus influencing tumour growth, invasion, and metastasis by increasing the activation of oncogenic pathways and limiting the expression of tumour suppressors. Furthermore, miRNAs and lncRNAs are also emerging as important mediators in drug-sensitivity and drug-resistance mechanisms. In the light of these premises, a number of pre-clinical and early clinical studies are exploring the potential of non-coding RNAs as new therapeutics. The aim of this review is to summarise the latest knowledge of the use of miRNAs and lncRNAs as therapeutic tools for cancer treatment.
      datePublished:2020-05-25T00:00:00Z
      dateModified:2020-05-25T00:00:00Z
      pageStart:261
      pageEnd:278
      license:http://creativecommons.org/licenses/by-nc/4.0/
      sameAs:https://doi.org/10.1007/s11523-020-00717-x
      keywords:
         Oncology
         Biomedicine
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11523-020-00717-x/MediaObjects/11523_2020_717_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11523-020-00717-x/MediaObjects/11523_2020_717_Fig2_HTML.png
      isPartOf:
         name:Targeted Oncology
         issn:
            1776-260X
            1776-2596
         volumeNumber:15
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Margherita Ratti
            affiliation:
                  name:The Institute of Cancer Research
                  address:
                     name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
                     type:PostalAddress
                  type:Organization
                  name:The Institute of Cancer Research
                  address:
                     name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
                     type:PostalAddress
                  type:Organization
                  name:Ospedale di Cremona
                  address:
                     name:Medical Department, Division of Oncology, ASST di Cremona, Ospedale di Cremona, Cremona, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andrea Lampis
            affiliation:
                  name:The Institute of Cancer Research
                  address:
                     name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
                     type:PostalAddress
                  type:Organization
                  name:The Institute of Cancer Research
                  address:
                     name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Michele Ghidini
            affiliation:
                  name:Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
                  address:
                     name:Division of Medical Oncology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Massimiliano Salati
            affiliation:
                  name:The Institute of Cancer Research
                  address:
                     name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
                     type:PostalAddress
                  type:Organization
                  name:The Institute of Cancer Research
                  address:
                     name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Milko B. Mirchev
            affiliation:
                  name:Medical University
                  address:
                     name:Clinic of Gastroenterology, Medical University, Varna, Bulgaria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nicola Valeri
            affiliation:
                  name:The Institute of Cancer Research
                  address:
                     name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
                     type:PostalAddress
                  type:Organization
                  name:The Institute of Cancer Research
                  address:
                     name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
                     type:PostalAddress
                  type:Organization
                  name:The Royal Marsden NHS Foundation Trust
                  address:
                     name:Department of Medicine, The Royal Marsden NHS Foundation Trust, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jens C. Hahne
            url:http://orcid.org/0000-0002-1425-7486
            affiliation:
                  name:The Institute of Cancer Research
                  address:
                     name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
                     type:PostalAddress
                  type:Organization
                  name:The Institute of Cancer Research
                  address:
                     name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Targeted Oncology
      issn:
         1776-260X
         1776-2596
      volumeNumber:15
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The Institute of Cancer Research
      address:
         name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
         type:PostalAddress
      name:The Institute of Cancer Research
      address:
         name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
         type:PostalAddress
      name:Ospedale di Cremona
      address:
         name:Medical Department, Division of Oncology, ASST di Cremona, Ospedale di Cremona, Cremona, Italy
         type:PostalAddress
      name:The Institute of Cancer Research
      address:
         name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
         type:PostalAddress
      name:The Institute of Cancer Research
      address:
         name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
         type:PostalAddress
      name:Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
      address:
         name:Division of Medical Oncology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
         type:PostalAddress
      name:The Institute of Cancer Research
      address:
         name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
         type:PostalAddress
      name:The Institute of Cancer Research
      address:
         name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
         type:PostalAddress
      name:Medical University
      address:
         name:Clinic of Gastroenterology, Medical University, Varna, Bulgaria
         type:PostalAddress
      name:The Institute of Cancer Research
      address:
         name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
         type:PostalAddress
      name:The Institute of Cancer Research
      address:
         name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
         type:PostalAddress
      name:The Royal Marsden NHS Foundation Trust
      address:
         name:Department of Medicine, The Royal Marsden NHS Foundation Trust, London, UK
         type:PostalAddress
      name:The Institute of Cancer Research
      address:
         name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
         type:PostalAddress
      name:The Institute of Cancer Research
      address:
         name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Margherita Ratti
      affiliation:
            name:The Institute of Cancer Research
            address:
               name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
               type:PostalAddress
            type:Organization
            name:The Institute of Cancer Research
            address:
               name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
               type:PostalAddress
            type:Organization
            name:Ospedale di Cremona
            address:
               name:Medical Department, Division of Oncology, ASST di Cremona, Ospedale di Cremona, Cremona, Italy
               type:PostalAddress
            type:Organization
      name:Andrea Lampis
      affiliation:
            name:The Institute of Cancer Research
            address:
               name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
               type:PostalAddress
            type:Organization
            name:The Institute of Cancer Research
            address:
               name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
               type:PostalAddress
            type:Organization
      name:Michele Ghidini
      affiliation:
            name:Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
            address:
               name:Division of Medical Oncology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
               type:PostalAddress
            type:Organization
      name:Massimiliano Salati
      affiliation:
            name:The Institute of Cancer Research
            address:
               name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
               type:PostalAddress
            type:Organization
            name:The Institute of Cancer Research
            address:
               name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
               type:PostalAddress
            type:Organization
      name:Milko B. Mirchev
      affiliation:
            name:Medical University
            address:
               name:Clinic of Gastroenterology, Medical University, Varna, Bulgaria
               type:PostalAddress
            type:Organization
      name:Nicola Valeri
      affiliation:
            name:The Institute of Cancer Research
            address:
               name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
               type:PostalAddress
            type:Organization
            name:The Institute of Cancer Research
            address:
               name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
               type:PostalAddress
            type:Organization
            name:The Royal Marsden NHS Foundation Trust
            address:
               name:Department of Medicine, The Royal Marsden NHS Foundation Trust, London, UK
               type:PostalAddress
            type:Organization
      name:Jens C. Hahne
      url:http://orcid.org/0000-0002-1425-7486
      affiliation:
            name:The Institute of Cancer Research
            address:
               name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
               type:PostalAddress
            type:Organization
            name:The Institute of Cancer Research
            address:
               name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
      name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
      name:Medical Department, Division of Oncology, ASST di Cremona, Ospedale di Cremona, Cremona, Italy
      name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
      name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
      name:Division of Medical Oncology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
      name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
      name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
      name:Clinic of Gastroenterology, Medical University, Varna, Bulgaria
      name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
      name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
      name:Department of Medicine, The Royal Marsden NHS Foundation Trust, London, UK
      name:Division of Molecular Pathology, The Institute of Cancer Research, London, UK
      name:Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK

External Links {🔗}(809)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Pace
  • Prism.js

CDN Services {📦}

  • Crossref

5.2s.