We are analyzing https://link.springer.com/article/10.1186/s12943-019-1102-3.

Title:
Harnessing tumor-associated macrophages as aids for cancer immunotherapy | Molecular Cancer
Description:
Cancer immunotherapies that engage immune cells to fight against tumors are proving to be powerful weapons in combating cancer and are becoming increasingly utilized in the clinics. However, for the majority of patients with solid tumors, little or no progress has been seen, presumably due to lack of adequate approaches that can reprogram the local immunosuppressive tumor milieu and thus reinvigorate antitumor immunity. Tumor-associated macrophages (TAMs), which abundantly infiltrate most solid tumors, could contribute to tumor progression by stimulating proliferation, angiogenesis, metastasis, and by providing a barrier against antitumor immunity. Initial TAMs-targeting strategies have shown efficacy across therapeutic modalities and tumor types in both preclinical and clinical studies. TAMs-targeted therapeutic approaches can be roughly divided into those that deplete TAMs and those that modulate TAMs activities. We here reviewed the mechanisms by which macrophages become immunosuppressive and compromise antitumor immunity. TAMs-focused therapeutic strategies are also summarized.
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Keywords {🔍}

pubmed, cancer, article, tumor, google, scholar, tams, macrophages, cas, cells, cell, immune, central, antitumor, tumors, therapy, macrophage, immunotherapy, receptor, targeting, immunity, checkpoint, tme, activation, immunosuppressive, progression, strategies, blockade, therapeutic, immunol, drug, responses, including, clinical, inhibition, delivery, tumorassociated, patients, res, function, metastasis, treatment, phenotype, response, pancreatic, complement, tgfβ, growth, models, mlike,

Topics {✒️}

anti-csf-1r antibody reveals post-sepsis-induced tumor progression tnf-related apoptosis-inducing ligand peripheral cd4+cd25- naive anti-cd47 antibody-mediated phagocytosis silica-based drug nanocapsule article download pdf antibody-dependent cellular cytotoxicity/phagocytosis tumour-induced systemic environment drug-silica complex filling de deus-wagatsuma vm cxcr4-cxcl12 axis--untapped potential enhancing n-glycan branching acquired antigen-presenting capabilities transforming growth factor-β related protein b7-h4 tumortropic monocyte-mediated delivery express cd3 ζ-chain phase 1b trial b7-h4 remains unknown cd4+cd25+ regulatory mesenchymal stem/stromal cells tumor-tropic drug delivery t-cell checkpoint immunotherapy increasing n-glycan branching anti-cd47 antibody synergizes dox-laden nanocapsule leads cxcl-12/cxcr-4 axis prevented indirect anti-tumor effects tenosynovial giant-cell tumor long blood-circulation times stromal cell-derived cxcl-12 checkpoint blockade-based immunotherapy inhibitory cd47-sirpα pathway facilitate breast-tumour metastasis previous pre-clinical studies producing anti-inflammatory cytokines b7-h4-expressing cells tumor-directed immune responses checkpoint blockade-based immunotherapies main tgf-β producers l-arginine catabolic pathways cell-mediated immune response small-molecule csf1r inhibitor b7-h4 expression identifies soluble sirpα-fc construct anti-tumor functional state tams-induced immune suppression ries ch cd47-sirpα axis resulted

Questions {❓}

Does choice of approaches, direct depletion or reprogramming of TAMs, depend on tumor type?
Is complement good or bad for cancer patients?
Is the scavenger receptor MARCO a new immune checkpoint?

Schema {🗺️}

WebPage:
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         headline:Harnessing tumor-associated macrophages as aids for cancer immunotherapy
         description:Cancer immunotherapies that engage immune cells to fight against tumors are proving to be powerful weapons in combating cancer and are becoming increasingly utilized in the clinics. However, for the majority of patients with solid tumors, little or no progress has been seen, presumably due to lack of adequate approaches that can reprogram the local immunosuppressive tumor milieu and thus reinvigorate antitumor immunity. Tumor-associated macrophages (TAMs), which abundantly infiltrate most solid tumors, could contribute to tumor progression by stimulating proliferation, angiogenesis, metastasis, and by providing a barrier against antitumor immunity. Initial TAMs-targeting strategies have shown efficacy across therapeutic modalities and tumor types in both preclinical and clinical studies. TAMs-targeted therapeutic approaches can be roughly divided into those that deplete TAMs and those that modulate TAMs activities. We here reviewed the mechanisms by which macrophages become immunosuppressive and compromise antitumor immunity. TAMs-focused therapeutic strategies are also summarized.
         datePublished:2019-12-05T00:00:00Z
         dateModified:2019-12-05T00:00:00Z
         pageStart:1
         pageEnd:16
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s12943-019-1102-3
         keywords:
            Tumor immunology
            Immunotherapy
            Immune checkpoint blockade
            Tumor-associated macrophage
            Combination therapy
            Cancer Research
            Oncology
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ScholarlyArticle:
      headline:Harnessing tumor-associated macrophages as aids for cancer immunotherapy
      description:Cancer immunotherapies that engage immune cells to fight against tumors are proving to be powerful weapons in combating cancer and are becoming increasingly utilized in the clinics. However, for the majority of patients with solid tumors, little or no progress has been seen, presumably due to lack of adequate approaches that can reprogram the local immunosuppressive tumor milieu and thus reinvigorate antitumor immunity. Tumor-associated macrophages (TAMs), which abundantly infiltrate most solid tumors, could contribute to tumor progression by stimulating proliferation, angiogenesis, metastasis, and by providing a barrier against antitumor immunity. Initial TAMs-targeting strategies have shown efficacy across therapeutic modalities and tumor types in both preclinical and clinical studies. TAMs-targeted therapeutic approaches can be roughly divided into those that deplete TAMs and those that modulate TAMs activities. We here reviewed the mechanisms by which macrophages become immunosuppressive and compromise antitumor immunity. TAMs-focused therapeutic strategies are also summarized.
      datePublished:2019-12-05T00:00:00Z
      dateModified:2019-12-05T00:00:00Z
      pageStart:1
      pageEnd:16
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      sameAs:https://doi.org/10.1186/s12943-019-1102-3
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         Tumor immunology
         Immunotherapy
         Immune checkpoint blockade
         Tumor-associated macrophage
         Combination therapy
         Cancer Research
         Oncology
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-019-1102-3/MediaObjects/12943_2019_1102_Fig2_HTML.png
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            type:Person
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               name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
               type:PostalAddress
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      name:Yongsha Pan
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            address:
               name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
               type:PostalAddress
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               type:PostalAddress
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      name:Changshun Shao
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      affiliation:
            name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
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      name:Yufang Shi
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            address:
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PostalAddress:
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
      name:Center of Translational Medicine, Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, China
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China

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