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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1186/s13045-022-01292-6.

Title:
Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape | Journal of Hematology & Oncology
Description:
Hypoxia, a common feature of the tumor microenvironment in various types of cancers, weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby reducing tumoral immunogenicity. Studies have demonstrated that hypoxia and hypoxia-inducible factors (HIFs) 1 and 2 alpha (HIF1A and HIF2A) are involved in tumor immune escape. Under hypoxia, activation of HIF1A induces a series of signaling events, including through programmed death receptor-1/programmed death ligand-1. Moreover, hypoxia triggers shedding of complex class I chain-associated molecules through nitric oxide signaling impairment to disrupt immune surveillance by natural killer cells. The HIF-1-galactose-3-O-sulfotransferase 1-sulfatide axis enhances tumor immune escape via increased tumor cell-platelet binding. HIF2A upregulates stem cell factor expression to recruit tumor-infiltrating mast cells and increase levels of cytokines interleukin-10 and transforming growth factor-β, resulting in an immunosuppressive tumor microenvironment. Additionally, HIF1A upregulates expression of tumor-associated long noncoding RNAs and suppresses immune cell function, enabling tumor immune escape. Overall, elucidating the underlying mechanisms by which HIFs promote evasion of tumor immune surveillance will allow for targeting HIF in tumor treatment. This review discusses the current knowledge of how hypoxia and HIFs facilitate tumor immune escape, with evidence to date implicating HIF1A as a molecular target in such immune escape. This review provides further insight into the mechanism of tumor immune escape, and strategies for tumor immunotherapy are suggested.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Science
  • Health & Fitness
  • Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,626,432 visitors per month in the current month.

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How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

tumor, pubmed, cells, immune, cancer, google, scholar, article, hifa, cas, cell, expression, escape, hypoxia, central, pdl, hypoxic, hif, promotes, growth, metastasis, hifs, signaling, resistance, microenvironment, tumors, carcinoma, wang, factor, induces, promote, stem, target, role, res, hypoxiainducible, mechanisms, gene, chen, lncrnas, zhang, factors, progression, angiogenesis, protein, conditions, emt, foxdas, evasion, mechanism,

Topics {✒️}

hif1-galactose-3-o-sulfotransferase 1 akt/mtor/hif-1 alpha axis regulating mir-185-5p/hmga2 axis nf-κb-interacting lncrna modulates atp-binding cassette subfamily hypoxia-/hif-1 alpha-driven factors pd-l1/pd-1 immune checkpoint hypoxia-inducible factors hif-1alpha pd-l1/pd-1 signaling reverses regulating pd-1/pd-l1 checkpoint mir-619-5p/camk1d axis hypoxia-induced pd-l1 expression hif-2α promotes conversion platelet-derived growth factor hif-induced foxd2-as1 vhl/hif pathway-driven cancers hypoxia-inducible factor-1α lncrna ilf3-as1 promotes hypoxia-inducible factor 1-alpha positive pd-l1 expression regulating lncrna foxd2-as1 pd-1/pd-l1 blockade upregulate small hairpin hif-1α von hippel-lindau high gal3st1-sulfatide expression hypoxia-inducible factor-1alpha hypoxia-driven immune escape alkbh5-mediated m6a-demethylation activation-induced cell death transforming growth factor-β sponging mir-27a-3p stem cell differentiation hypoxia enhanced mdsc-mediated tgf-α/egfr pathway [163] neoantigen-directed immune escape hypoxia-induced vista promotes mediating nf-κb activation pi3k/akt signal induced small-cell lung carcinoma tumor-infiltrating mast cells small-cell lung cancer tgf-β2 jointly activate article download pdf pd-d1/pd-l1 17-allyl-amino-geldanamycin inhibits hypoxia-mediated immune escape nk cell-mediated cytotoxicity zinc finger mynd-type hypoxia-mediated immune evasion pd-1/pd-l1 pathway

Questions {❓}

  • Functional regulation of HIF-1α under normoxia–is there more than post-translational regulation?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape
         description:Hypoxia, a common feature of the tumor microenvironment in various types of cancers, weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby reducing tumoral immunogenicity. Studies have demonstrated that hypoxia and hypoxia-inducible factors (HIFs) 1 and 2 alpha (HIF1A and HIF2A) are involved in tumor immune escape. Under hypoxia, activation of HIF1A induces a series of signaling events, including through programmed death receptor-1/programmed death ligand-1. Moreover, hypoxia triggers shedding of complex class I chain-associated molecules through nitric oxide signaling impairment to disrupt immune surveillance by natural killer cells. The HIF-1-galactose-3-O-sulfotransferase 1-sulfatide axis enhances tumor immune escape via increased tumor cell-platelet binding. HIF2A upregulates stem cell factor expression to recruit tumor-infiltrating mast cells and increase levels of cytokines interleukin-10 and transforming growth factor-β, resulting in an immunosuppressive tumor microenvironment. Additionally, HIF1A upregulates expression of tumor-associated long noncoding RNAs and suppresses immune cell function, enabling tumor immune escape. Overall, elucidating the underlying mechanisms by which HIFs promote evasion of tumor immune surveillance will allow for targeting HIF in tumor treatment. This review discusses the current knowledge of how hypoxia and HIFs facilitate tumor immune escape, with evidence to date implicating HIF1A as a molecular target in such immune escape. This review provides further insight into the mechanism of tumor immune escape, and strategies for tumor immunotherapy are suggested.
         datePublished:2022-06-03T00:00:00Z
         dateModified:2022-06-03T00:00:00Z
         pageStart:1
         pageEnd:18
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s13045-022-01292-6
         keywords:
            Hypoxia
            Hypoxia-inducible factors
            Tumor disease
            Immunotherapy
            Personalized medicine
            Oncology
            Hematology
            Cancer Research
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            issn:
               1756-8722
            volumeNumber:15
            type:
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               name:Qinghua Wu
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                     address:
                        name:College of Life Science, Yangtze University, Jingzhou, China
                        type:PostalAddress
                     type:Organization
                     name:University of Hradec Kralove
                     address:
                        name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
                        type:PostalAddress
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               affiliation:
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                        name:College of Life Science, Yangtze University, Jingzhou, China
                        type:PostalAddress
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                     name:University of Hradec Kralove
                     address:
                        name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
                        type:PostalAddress
                     type:Organization
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                     name:Mendel University in Brno
                     address:
                        name:Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic
                        type:PostalAddress
                     type:Organization
                     name:Brno University of Technology
                     address:
                        name:Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wenda Wu
               affiliation:
                     name:Nanjing Agricultural University
                     address:
                        name:MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
                        type:PostalAddress
                     type:Organization
                     name:University of Hradec Kralove
                     address:
                        name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Kamil Kuca
               affiliation:
                     name:University of Hradec Kralove
                     address:
                        name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Vojtech Adam
               url:http://orcid.org/0000-0002-8527-286X
               affiliation:
                     name:Mendel University in Brno
                     address:
                        name:Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic
                        type:PostalAddress
                     type:Organization
                     name:Brno University of Technology
                     address:
                        name:Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic
                        type:PostalAddress
                     type:Organization
               email:[email protected]
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      context:https://schema.org
ScholarlyArticle:
      headline:Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape
      description:Hypoxia, a common feature of the tumor microenvironment in various types of cancers, weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby reducing tumoral immunogenicity. Studies have demonstrated that hypoxia and hypoxia-inducible factors (HIFs) 1 and 2 alpha (HIF1A and HIF2A) are involved in tumor immune escape. Under hypoxia, activation of HIF1A induces a series of signaling events, including through programmed death receptor-1/programmed death ligand-1. Moreover, hypoxia triggers shedding of complex class I chain-associated molecules through nitric oxide signaling impairment to disrupt immune surveillance by natural killer cells. The HIF-1-galactose-3-O-sulfotransferase 1-sulfatide axis enhances tumor immune escape via increased tumor cell-platelet binding. HIF2A upregulates stem cell factor expression to recruit tumor-infiltrating mast cells and increase levels of cytokines interleukin-10 and transforming growth factor-β, resulting in an immunosuppressive tumor microenvironment. Additionally, HIF1A upregulates expression of tumor-associated long noncoding RNAs and suppresses immune cell function, enabling tumor immune escape. Overall, elucidating the underlying mechanisms by which HIFs promote evasion of tumor immune surveillance will allow for targeting HIF in tumor treatment. This review discusses the current knowledge of how hypoxia and HIFs facilitate tumor immune escape, with evidence to date implicating HIF1A as a molecular target in such immune escape. This review provides further insight into the mechanism of tumor immune escape, and strategies for tumor immunotherapy are suggested.
      datePublished:2022-06-03T00:00:00Z
      dateModified:2022-06-03T00:00:00Z
      pageStart:1
      pageEnd:18
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s13045-022-01292-6
      keywords:
         Hypoxia
         Hypoxia-inducible factors
         Tumor disease
         Immunotherapy
         Personalized medicine
         Oncology
         Hematology
         Cancer Research
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-022-01292-6/MediaObjects/13045_2022_1292_Fig1_HTML.png
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      isPartOf:
         name:Journal of Hematology & Oncology
         issn:
            1756-8722
         volumeNumber:15
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Qinghua Wu
            affiliation:
                  name:Yangtze University
                  address:
                     name:College of Life Science, Yangtze University, Jingzhou, China
                     type:PostalAddress
                  type:Organization
                  name:University of Hradec Kralove
                  address:
                     name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Li You
            affiliation:
                  name:Yangtze University
                  address:
                     name:College of Life Science, Yangtze University, Jingzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Eugenie Nepovimova
            affiliation:
                  name:University of Hradec Kralove
                  address:
                     name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zbynek Heger
            affiliation:
                  name:Mendel University in Brno
                  address:
                     name:Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic
                     type:PostalAddress
                  type:Organization
                  name:Brno University of Technology
                  address:
                     name:Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wenda Wu
            affiliation:
                  name:Nanjing Agricultural University
                  address:
                     name:MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
                     type:PostalAddress
                  type:Organization
                  name:University of Hradec Kralove
                  address:
                     name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Kamil Kuca
            affiliation:
                  name:University of Hradec Kralove
                  address:
                     name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Vojtech Adam
            url:http://orcid.org/0000-0002-8527-286X
            affiliation:
                  name:Mendel University in Brno
                  address:
                     name:Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic
                     type:PostalAddress
                  type:Organization
                  name:Brno University of Technology
                  address:
                     name:Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Journal of Hematology & Oncology
      issn:
         1756-8722
      volumeNumber:15
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Yangtze University
      address:
         name:College of Life Science, Yangtze University, Jingzhou, China
         type:PostalAddress
      name:University of Hradec Kralove
      address:
         name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
         type:PostalAddress
      name:Yangtze University
      address:
         name:College of Life Science, Yangtze University, Jingzhou, China
         type:PostalAddress
      name:University of Hradec Kralove
      address:
         name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
         type:PostalAddress
      name:Mendel University in Brno
      address:
         name:Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic
         type:PostalAddress
      name:Brno University of Technology
      address:
         name:Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic
         type:PostalAddress
      name:Nanjing Agricultural University
      address:
         name:MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
         type:PostalAddress
      name:University of Hradec Kralove
      address:
         name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
         type:PostalAddress
      name:University of Hradec Kralove
      address:
         name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
         type:PostalAddress
      name:Mendel University in Brno
      address:
         name:Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic
         type:PostalAddress
      name:Brno University of Technology
      address:
         name:Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Qinghua Wu
      affiliation:
            name:Yangtze University
            address:
               name:College of Life Science, Yangtze University, Jingzhou, China
               type:PostalAddress
            type:Organization
            name:University of Hradec Kralove
            address:
               name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
               type:PostalAddress
            type:Organization
      name:Li You
      affiliation:
            name:Yangtze University
            address:
               name:College of Life Science, Yangtze University, Jingzhou, China
               type:PostalAddress
            type:Organization
      name:Eugenie Nepovimova
      affiliation:
            name:University of Hradec Kralove
            address:
               name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
               type:PostalAddress
            type:Organization
      name:Zbynek Heger
      affiliation:
            name:Mendel University in Brno
            address:
               name:Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic
               type:PostalAddress
            type:Organization
            name:Brno University of Technology
            address:
               name:Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic
               type:PostalAddress
            type:Organization
      name:Wenda Wu
      affiliation:
            name:Nanjing Agricultural University
            address:
               name:MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
               type:PostalAddress
            type:Organization
            name:University of Hradec Kralove
            address:
               name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Kamil Kuca
      affiliation:
            name:University of Hradec Kralove
            address:
               name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Vojtech Adam
      url:http://orcid.org/0000-0002-8527-286X
      affiliation:
            name:Mendel University in Brno
            address:
               name:Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic
               type:PostalAddress
            type:Organization
            name:Brno University of Technology
            address:
               name:Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:College of Life Science, Yangtze University, Jingzhou, China
      name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
      name:College of Life Science, Yangtze University, Jingzhou, China
      name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
      name:Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic
      name:Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic
      name:MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
      name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
      name:Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
      name:Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic
      name:Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic

External Links {🔗}(575)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

CDN Services {📦}

  • Crossref

5.8s.