We are analyzing https://link.springer.com/article/10.1186/s40364-023-00457-w.

Title:
The role and regulation of Maf proteins in cancer | Biomarker Research
Description:
The Maf proteins (Mafs) belong to basic leucine zipper transcription factors and are members of the activator protein-1 (AP-1) superfamily. There are two subgroups of Mafs: large Mafs and small Mafs, which are involved in a wide range of biological processes, such as the cell cycle, proliferation, oxidative stress, and inflammation. Therefore, dysregulation of Mafs can affect cell fate and is closely associated with diverse diseases. Accumulating evidence has established both large and small Mafs as mediators of tumor development. In this review, we first briefly describe the structure and physiological functions of Mafs. Then we summarize the upstream regulatory mechanisms that control the expression and activity of Mafs. Furthermore, we discuss recent studies on the critical role of Mafs in cancer progression, including cancer proliferation, apoptosis, metastasis, tumor/stroma interaction and angiogenesis. We also review the clinical implications of Mafs, namely their potential possibilities and limitations as biomarkers and therapeutic targets in cancer.
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Keywords {🔍}

article, google, scholar, cancer, mafs, cas, cell, cmaf, expression, cells, transcription, tumor, small, proteins, proliferation, maf, large, zhang, metastasis, multiple, factor, target, myeloma, wang, mafb, protein, gene, chen, biol, factors, apoptosis, res, genes, growth, mafg, transcriptional, binding, targeting, mol, regulation, activity, signaling, mafa, carcinoma, role, maff, liu, development, human, domain,

Topics {✒️}

c-jun/c-fos/srebp1 axis rat c-maf gene harbored p62-keap1-nrf2 pathway protects circ-itch/mir-224-5p axis ubiquitin-conjugating enzyme ube2o htlv-1 basic leucine-zipper ark5-driven t-cell lymphomas integrin-binding protein e-cadherin large-scale population-based studies keap1/nrf2/small mafs pathway regulating mir-744-5p/mafg axis basic region/leucine zipper adult t-cell leukemia angioimmunoblastic t-cell lymphoma noncoding rna revolution-trashing transcription factor c-maf c-maf transcription factor rna-induced silencing complex proto-oncogene c-maf c-maf proto-oncogene angioimmunoblastic t-cell lymphomas adhesion protein e-cadherin transcription factor hif-1α glutamate-cysteine ligase expression producing pro-angiogenic factors ubiquitin-specific protease usp5 nf-e2-related factor 1 c-maf-mediated interactions microrna-129-5p regulates glycolysis osteolysis-mediated bone metastasis microrna-mediated gene silencing article download pdf pkcalpha/nf-kappab pathway c-maf negatively regulates lens-specific maf protein creb-binding protein/p300 retaining mir-30a–3p otub1/c-maf axis usp5/c-maf axis compound mouse mutants mafg/nrf2 heterodimer formation ser/thr kinase gsk3 c-maf binding motif downregulating e-cadherin expression gsk3-mediated maf phosphorylation downregulated c-maf levels cellular counterpart c-maf c-maf promoter construct [61] amino acid codes c-maf protein degradation

Questions {❓}

Mafs as a biomarker in cancer?
Mafs as a therapeutic target in cancer?
Oxidative stress, inflammation, and cancer: how are they linked?
Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators?

Schema {🗺️}

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         headline:The role and regulation of Maf proteins in cancer
         description:The Maf proteins (Mafs) belong to basic leucine zipper transcription factors and are members of the activator protein-1 (AP-1) superfamily. There are two subgroups of Mafs: large Mafs and small Mafs, which are involved in a wide range of biological processes, such as the cell cycle, proliferation, oxidative stress, and inflammation. Therefore, dysregulation of Mafs can affect cell fate and is closely associated with diverse diseases. Accumulating evidence has established both large and small Mafs as mediators of tumor development. In this review, we first briefly describe the structure and physiological functions of Mafs. Then we summarize the upstream regulatory mechanisms that control the expression and activity of Mafs. Furthermore, we discuss recent studies on the critical role of Mafs in cancer progression, including cancer proliferation, apoptosis, metastasis, tumor/stroma interaction and angiogenesis. We also review the clinical implications of Mafs, namely their potential possibilities and limitations as biomarkers and therapeutic targets in cancer.
         datePublished:2023-02-07T00:00:00Z
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            Proliferation
            Metastasis
            Biomarkers
            Therapeutic targets
            Biomedicine
            general
            Cancer Research
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ScholarlyArticle:
      headline:The role and regulation of Maf proteins in cancer
      description:The Maf proteins (Mafs) belong to basic leucine zipper transcription factors and are members of the activator protein-1 (AP-1) superfamily. There are two subgroups of Mafs: large Mafs and small Mafs, which are involved in a wide range of biological processes, such as the cell cycle, proliferation, oxidative stress, and inflammation. Therefore, dysregulation of Mafs can affect cell fate and is closely associated with diverse diseases. Accumulating evidence has established both large and small Mafs as mediators of tumor development. In this review, we first briefly describe the structure and physiological functions of Mafs. Then we summarize the upstream regulatory mechanisms that control the expression and activity of Mafs. Furthermore, we discuss recent studies on the critical role of Mafs in cancer progression, including cancer proliferation, apoptosis, metastasis, tumor/stroma interaction and angiogenesis. We also review the clinical implications of Mafs, namely their potential possibilities and limitations as biomarkers and therapeutic targets in cancer.
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      dateModified:2023-02-07T00:00:00Z
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      sameAs:https://doi.org/10.1186/s40364-023-00457-w
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         Maf proteins
         Proliferation
         Metastasis
         Biomarkers
         Therapeutic targets
         Biomedicine
         general
         Cancer Research
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         name:Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, China
         type:PostalAddress
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         name:Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, China
         type:PostalAddress
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         type:PostalAddress
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         name:Department of Ultrasonic Imaging, Xiangya Hospital, Central South University, Changsha, China
         type:PostalAddress
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      address:
         name:Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, China
         type:PostalAddress
      name:Xiangya Hospital, Central South University
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         name:Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, China
         type:PostalAddress
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         name:Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, China
         type:PostalAddress
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               type:PostalAddress
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               type:PostalAddress
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               type:PostalAddress
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      name:Ying Fu
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            name:Xiangya Hospital, Central South University
            address:
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               type:PostalAddress
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      name:Ting Liu
      affiliation:
            name:Xiangya Hospital, Central South University
            address:
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               type:PostalAddress
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      name:Yongheng Chen
      affiliation:
            name:Xiangya Hospital, Central South University
            address:
               name:Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, China
               type:PostalAddress
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PostalAddress:
      name:Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, China
      name:Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, China
      name:Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, China
      name:Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, China
      name:Department of Ultrasonic Imaging, Xiangya Hospital, Central South University, Changsha, China
      name:Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, China
      name:Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, China
      name:Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South University, Changsha, China
      name:National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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