Here's how LINK.SPRINGER.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1186/s13287-020-02090-y.

Title:
Biomaterial-supported MSC transplantation enhances cell–cell communication for spinal cord injury | Stem Cell Research & Therapy
Description:
The spinal cord is part of the central nervous system (CNS) and serves to connect the brain to the peripheral nervous system and peripheral tissues. The cell types that primarily comprise the spinal cord are neurons and several categories of glia, including astrocytes, oligodendrocytes, and microglia. Ependymal cells and small populations of endogenous stem cells, such as oligodendrocyte progenitor cells, also reside in the spinal cord. Neurons are interconnected in circuits; those that process cutaneous sensory input are mainly located in the dorsal spinal cord, while those involved in proprioception and motor control are predominately located in the ventral spinal cord. Due to the importance of the spinal cord, neurodegenerative disorders and traumatic injuries affecting the spinal cord will lead to motor deficits and loss of sensory inputs. Spinal cord injury (SCI), resulting in paraplegia and tetraplegia as a result of deleterious interconnected mechanisms encompassed by the primary and secondary injury, represents a heterogeneously behavioral and cognitive deficit that remains incurable. Following SCI, various barriers containing the neuroinflammation, neural tissue defect (neurons, microglia, astrocytes, and oligodendrocytes), cavity formation, loss of neuronal circuitry, and function must be overcame. Notably, the pro-inflammatory and anti-inflammatory effects of cell–cell communication networks play critical roles in homeostatic, driving the pathophysiologic and consequent cognitive outcomes. In the spinal cord, astrocytes, oligodendrocytes, and microglia are involved in not only development but also pathology. Glial cells play dual roles (negative vs. positive effects) in these processes. After SCI, detrimental effects usually dominate and significantly retard functional recovery, and curbing these effects is critical for promoting neurological improvement. Indeed, residential innate immune cells (microglia and astrocytes) and infiltrating leukocytes (macrophages and neutrophils), activated by SCI, give rise to full-blown inflammatory cascades. These inflammatory cells release neurotoxins (proinflammatory cytokines and chemokines, free radicals, excitotoxic amino acids, nitric oxide (NO)), all of which partake in axonal and neuronal deficit. Given the various multifaceted obstacles in SCI treatment, a combinatorial therapy of cell transplantation and biomaterial implantation may be addressed in detail here. For the sake of preserving damaged tissue integrity and providing physical support and trophic supply for axon regeneration, MSC transplantation has come to the front stage in therapy for SCI with the constant progress of stem cell engineering. MSC transplantation promotes scaffold integration and regenerative growth potential. Integrating into the implanted scaffold, MSCs influence implant integration by improving the healing process. Conversely, biomaterial scaffolds offer MSCs with a sheltered microenvironment from the surrounding pathological changes, in addition to bridging connection spinal cord stump and offering physical and directional support for axonal regeneration. Besides, Biomaterial scaffolds mimic the extracellular matrix to suppress immune responses. Here, we review the advances in combinatorial biomaterial scaffolds and MSC transplantation approach that targets certain aspects of various intercellular communications in the pathologic process following SCI. Finally, the challenges of biomaterial-supported MSC transplantation and its future direction for neuronal regeneration will be presented.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {šŸ“š}

  • Science
  • Education
  • Health & Fitness

Content Management System {šŸ“}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {šŸ“ˆ}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {šŸ’ø}

We're unsure if the website is profiting.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {šŸ”}

pubmed, cells, article, google, scholar, cas, sci, cell, cord, spinal, mscs, injury, stem, central, transplantation, msc, activation, microglia, mesenchymal, astrocytes, tissue, regeneration, factor, neurons, oligodendrocytes, glial, functional, growth, inflammatory, macrophages, factors, neural, immune, antiinflammatory, myelin, effects, macrophage, promote, differentiation, oligodendrocyte, cytokines, neuroinflammation, recovery, zhang, expression, remyelination, therapy, neurotrophic, reactive, chen,

Topics {āœ’ļø}

laminin-coated phema-moetacl hydrogel stromal cell-derived factor-1α il-1 receptor/myd88-dependent fashion ischemic post/pre-conditioning necrosis/hemorrhage induced-demyelination occurs adipose mesenchymal stromal dna nanoparticle-mediated transfection biomaterial-supported msc transplantation stem cell-based therapies human sk-n-sh glial-derived neurotrophic factor platelet-derived growth factor glial-derived growth factor astrocyte-derived extracellular vesicles rada16-bdnf peptide scaffold nsc-derived myelinating cells brain-derived neurotrophic factor msc-derived exosomes decrease anti-inflammatory cell therapy brain-derived growth factor alpha b-crystallin spinal cord-injured mice msc-derived soluble factors transplant-derived secreted molecules astrocyte-derived conditioned medium avidin-biotin binding system mesenchymal stem cells functional nanoparticle-enhanced conduits pre-existing blood vessels blood-spinal cord barrier macrophage-derived soluble factors nerve injury-induced pain generate human microglia macrophage inflammatory protein-1alpha article download pdf mesenchymal stromal cells fetal tissue grafts neural stem cells bdnf-trkb signaling inhibits sialic acid-binding ig full-blown inflammatory cascades mesenchymal progenitor cells anti-oligodendrogenesis determinant id2 ppar-gamma signaling pathway central nervous system chitosan-gelatin-based microgel increased forelimb–hindlimb coordination decreased nf-Īŗb signaling affects endothelial cells hgf-c-met pathway

Questions {ā“}

  • Clinical translation of stem cell based interventions for spinal cord injury - are we there yet?
  • Repairing peripheral nerves: is there a role for carbon nanotubes?

Schema {šŸ—ŗļø}

WebPage:
      mainEntity:
         headline:Biomaterial-supported MSC transplantation enhances cell–cell communication for spinal cord injury
         description:The spinal cord is part of the central nervous system (CNS) and serves to connect the brain to the peripheral nervous system and peripheral tissues. The cell types that primarily comprise the spinal cord are neurons and several categories of glia, including astrocytes, oligodendrocytes, and microglia. Ependymal cells and small populations of endogenous stem cells, such as oligodendrocyte progenitor cells, also reside in the spinal cord. Neurons are interconnected in circuits; those that process cutaneous sensory input are mainly located in the dorsal spinal cord, while those involved in proprioception and motor control are predominately located in the ventral spinal cord. Due to the importance of the spinal cord, neurodegenerative disorders and traumatic injuries affecting the spinal cord will lead to motor deficits and loss of sensory inputs. Spinal cord injury (SCI), resulting in paraplegia and tetraplegia as a result of deleterious interconnected mechanisms encompassed by the primary and secondary injury, represents a heterogeneously behavioral and cognitive deficit that remains incurable. Following SCI, various barriers containing the neuroinflammation, neural tissue defect (neurons, microglia, astrocytes, and oligodendrocytes), cavity formation, loss of neuronal circuitry, and function must be overcame. Notably, the pro-inflammatory and anti-inflammatory effects of cell–cell communication networks play critical roles in homeostatic, driving the pathophysiologic and consequent cognitive outcomes. In the spinal cord, astrocytes, oligodendrocytes, and microglia are involved in not only development but also pathology. Glial cells play dual roles (negative vs. positive effects) in these processes. After SCI, detrimental effects usually dominate and significantly retard functional recovery, and curbing these effects is critical for promoting neurological improvement. Indeed, residential innate immune cells (microglia and astrocytes) and infiltrating leukocytes (macrophages and neutrophils), activated by SCI, give rise to full-blown inflammatory cascades. These inflammatory cells release neurotoxins (proinflammatory cytokines and chemokines, free radicals, excitotoxic amino acids, nitric oxide (NO)), all of which partake in axonal and neuronal deficit. Given the various multifaceted obstacles in SCI treatment, a combinatorial therapy of cell transplantation and biomaterial implantation may be addressed in detail here. For the sake of preserving damaged tissue integrity and providing physical support and trophic supply for axon regeneration, MSC transplantation has come to the front stage in therapy for SCI with the constant progress of stem cell engineering. MSC transplantation promotes scaffold integration and regenerative growth potential. Integrating into the implanted scaffold, MSCs influence implant integration by improving the healing process. Conversely, biomaterial scaffolds offer MSCs with a sheltered microenvironment from the surrounding pathological changes, in addition to bridging connection spinal cord stump and offering physical and directional support for axonal regeneration. Besides, Biomaterial scaffolds mimic the extracellular matrix to suppress immune responses. Here, we review the advances in combinatorial biomaterial scaffolds and MSC transplantation approach that targets certain aspects of various intercellular communications in the pathologic process following SCI. Finally, the challenges of biomaterial-supported MSC transplantation and its future direction for neuronal regeneration will be presented.
         datePublished:2021-01-07T00:00:00Z
         dateModified:2021-01-07T00:00:00Z
         pageStart:1
         pageEnd:16
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s13287-020-02090-y
         keywords:
            Biomaterial
            MSC transplantation
            Spinal cord injury
            Combinatorial therapy
            Neuroinflammation
            Stem Cells
            Cell Biology
            Regenerative Medicine/Tissue Engineering
            Biomedical Engineering and Bioengineering
         image:
         isPartOf:
            name:Stem Cell Research & Therapy
            issn:
               1757-6512
            volumeNumber:12
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Bin Lv
               affiliation:
                     name:The Affiliated People’s Hospital of Jiangsu University
                     address:
                        name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xing Zhang
               affiliation:
                     name:RWTH Aachen University Hospital
                     address:
                        name:Department of Trauma and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jishan Yuan
               affiliation:
                     name:The Affiliated People’s Hospital of Jiangsu University
                     address:
                        name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yongxin Chen
               affiliation:
                     name:The Affiliated People’s Hospital of Jiangsu University
                     address:
                        name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hua Ding
               affiliation:
                     name:The Affiliated People’s Hospital of Jiangsu University
                     address:
                        name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xinbing Cao
               affiliation:
                     name:The Affiliated Hospital of Jiangsu University
                     address:
                        name:Department of Orthopedics, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Anquan Huang
               affiliation:
                     name:Suzhou Municipal Hospital
                     address:
                        name:Department of Orthopedics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Biomaterial-supported MSC transplantation enhances cell–cell communication for spinal cord injury
      description:The spinal cord is part of the central nervous system (CNS) and serves to connect the brain to the peripheral nervous system and peripheral tissues. The cell types that primarily comprise the spinal cord are neurons and several categories of glia, including astrocytes, oligodendrocytes, and microglia. Ependymal cells and small populations of endogenous stem cells, such as oligodendrocyte progenitor cells, also reside in the spinal cord. Neurons are interconnected in circuits; those that process cutaneous sensory input are mainly located in the dorsal spinal cord, while those involved in proprioception and motor control are predominately located in the ventral spinal cord. Due to the importance of the spinal cord, neurodegenerative disorders and traumatic injuries affecting the spinal cord will lead to motor deficits and loss of sensory inputs. Spinal cord injury (SCI), resulting in paraplegia and tetraplegia as a result of deleterious interconnected mechanisms encompassed by the primary and secondary injury, represents a heterogeneously behavioral and cognitive deficit that remains incurable. Following SCI, various barriers containing the neuroinflammation, neural tissue defect (neurons, microglia, astrocytes, and oligodendrocytes), cavity formation, loss of neuronal circuitry, and function must be overcame. Notably, the pro-inflammatory and anti-inflammatory effects of cell–cell communication networks play critical roles in homeostatic, driving the pathophysiologic and consequent cognitive outcomes. In the spinal cord, astrocytes, oligodendrocytes, and microglia are involved in not only development but also pathology. Glial cells play dual roles (negative vs. positive effects) in these processes. After SCI, detrimental effects usually dominate and significantly retard functional recovery, and curbing these effects is critical for promoting neurological improvement. Indeed, residential innate immune cells (microglia and astrocytes) and infiltrating leukocytes (macrophages and neutrophils), activated by SCI, give rise to full-blown inflammatory cascades. These inflammatory cells release neurotoxins (proinflammatory cytokines and chemokines, free radicals, excitotoxic amino acids, nitric oxide (NO)), all of which partake in axonal and neuronal deficit. Given the various multifaceted obstacles in SCI treatment, a combinatorial therapy of cell transplantation and biomaterial implantation may be addressed in detail here. For the sake of preserving damaged tissue integrity and providing physical support and trophic supply for axon regeneration, MSC transplantation has come to the front stage in therapy for SCI with the constant progress of stem cell engineering. MSC transplantation promotes scaffold integration and regenerative growth potential. Integrating into the implanted scaffold, MSCs influence implant integration by improving the healing process. Conversely, biomaterial scaffolds offer MSCs with a sheltered microenvironment from the surrounding pathological changes, in addition to bridging connection spinal cord stump and offering physical and directional support for axonal regeneration. Besides, Biomaterial scaffolds mimic the extracellular matrix to suppress immune responses. Here, we review the advances in combinatorial biomaterial scaffolds and MSC transplantation approach that targets certain aspects of various intercellular communications in the pathologic process following SCI. Finally, the challenges of biomaterial-supported MSC transplantation and its future direction for neuronal regeneration will be presented.
      datePublished:2021-01-07T00:00:00Z
      dateModified:2021-01-07T00:00:00Z
      pageStart:1
      pageEnd:16
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s13287-020-02090-y
      keywords:
         Biomaterial
         MSC transplantation
         Spinal cord injury
         Combinatorial therapy
         Neuroinflammation
         Stem Cells
         Cell Biology
         Regenerative Medicine/Tissue Engineering
         Biomedical Engineering and Bioengineering
      image:
      isPartOf:
         name:Stem Cell Research & Therapy
         issn:
            1757-6512
         volumeNumber:12
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Bin Lv
            affiliation:
                  name:The Affiliated People’s Hospital of Jiangsu University
                  address:
                     name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xing Zhang
            affiliation:
                  name:RWTH Aachen University Hospital
                  address:
                     name:Department of Trauma and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jishan Yuan
            affiliation:
                  name:The Affiliated People’s Hospital of Jiangsu University
                  address:
                     name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yongxin Chen
            affiliation:
                  name:The Affiliated People’s Hospital of Jiangsu University
                  address:
                     name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hua Ding
            affiliation:
                  name:The Affiliated People’s Hospital of Jiangsu University
                  address:
                     name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xinbing Cao
            affiliation:
                  name:The Affiliated Hospital of Jiangsu University
                  address:
                     name:Department of Orthopedics, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Anquan Huang
            affiliation:
                  name:Suzhou Municipal Hospital
                  address:
                     name:Department of Orthopedics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Stem Cell Research & Therapy
      issn:
         1757-6512
      volumeNumber:12
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The Affiliated People’s Hospital of Jiangsu University
      address:
         name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
         type:PostalAddress
      name:RWTH Aachen University Hospital
      address:
         name:Department of Trauma and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany
         type:PostalAddress
      name:The Affiliated People’s Hospital of Jiangsu University
      address:
         name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
         type:PostalAddress
      name:The Affiliated People’s Hospital of Jiangsu University
      address:
         name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
         type:PostalAddress
      name:The Affiliated People’s Hospital of Jiangsu University
      address:
         name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
         type:PostalAddress
      name:The Affiliated Hospital of Jiangsu University
      address:
         name:Department of Orthopedics, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
         type:PostalAddress
      name:Suzhou Municipal Hospital
      address:
         name:Department of Orthopedics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Bin Lv
      affiliation:
            name:The Affiliated People’s Hospital of Jiangsu University
            address:
               name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
               type:PostalAddress
            type:Organization
      name:Xing Zhang
      affiliation:
            name:RWTH Aachen University Hospital
            address:
               name:Department of Trauma and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany
               type:PostalAddress
            type:Organization
      name:Jishan Yuan
      affiliation:
            name:The Affiliated People’s Hospital of Jiangsu University
            address:
               name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
               type:PostalAddress
            type:Organization
      name:Yongxin Chen
      affiliation:
            name:The Affiliated People’s Hospital of Jiangsu University
            address:
               name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
               type:PostalAddress
            type:Organization
      name:Hua Ding
      affiliation:
            name:The Affiliated People’s Hospital of Jiangsu University
            address:
               name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
               type:PostalAddress
            type:Organization
      name:Xinbing Cao
      affiliation:
            name:The Affiliated Hospital of Jiangsu University
            address:
               name:Department of Orthopedics, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Anquan Huang
      affiliation:
            name:Suzhou Municipal Hospital
            address:
               name:Department of Orthopedics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
      name:Department of Trauma and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Germany
      name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
      name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
      name:Department of Orthopedics, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
      name:Department of Orthopedics, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
      name:Department of Orthopedics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China

External Links {šŸ”—}(494)

Analytics and Tracking {šŸ“Š}

  • Google Tag Manager

Libraries {šŸ“š}

  • Clipboard.js
  • Prism.js

CDN Services {šŸ“¦}

  • Crossref

5.6s.