We are analyzing https://link.springer.com/article/10.1186/s13045-017-0430-2.

Title:
Tumor-associated macrophages: from basic research to clinical application | Journal of Hematology & Oncology
Description:
The fact that various immune cells, including macrophages, can be found in tumor tissues has long been known. With the introduction of concept that macrophages differentiate into a classically or alternatively activated phenotype, the role of tumor-associated macrophages (TAMs) is now beginning to be elucidated. TAMs act as “protumoral macrophages,” contributing to disease progression. TAMs can promote initiation and metastasis of tumor cells, inhibit antitumor immune responses mediated by T cells, and stimulate tumor angiogenesis and subsequently tumor progression. As the relationship between TAMs and malignant tumors becomes clearer, TAMs are beginning to be seen as potential biomarkers for diagnosis and prognosis of cancers, as well as therapeutic targets in these cases. In this review, we will discuss the origin, polarization, and role of TAMs in human malignant tumors, as well as how TAMs can be used as diagnostic and prognostic biomarkers and therapeutic targets of cancer in clinics.
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Keywords {🔍}

pubmed, tams, tumor, macrophages, cancer, article, google, scholar, cells, cas, central, progression, cell, macrophage, growth, tumorassociated, metastasis, tumors, polarization, factor, wang, immune, clinical, zhang, ccl, promote, therapeutic, targeting, fig, role, cancers, shown, patients, antitumor, treatment, carcinoma, phenotype, human, microenvironment, factors, table, angiogenesis, malignant, potential, study, recruitment, results, phase, nct, monocytes,

Topics {✒️}

monocyte/macrophage-derived soluble cd163 pd1/pd-l1 signaling pathway platelet-derived growth factor ikk/nf-kappab activation pathway single-chain peptide bound msc-derived mfg-e8 article download pdf pro-angiogenic m2-polarized phenotype microrna-26a suppresses recruitment adenoma-linked barrier defects transforming growing factor-β myeloid-derived suppressor cells de-deus-wagatsuma vm epithelial-mesenchymal transition immunotoxin-conjugated monoclonal antibodies tam-derived il-6 promotes tam-derived prostaglandin e2 microsatellite-unstable gastric carcinoma tam-derived angiogenic factors costimulatory molecule pd-l1 colony-stimulating factor endothelial cell-produced angiopoietin-2 radiation-induced tumor hypoxia hif-1α induced il-10 induce pro-inflammatory cytokines thymosin-α prolongs survival endothelial protein markers hypoxia-inducible factor tumor-derived extracellular matrix protease-dependent ecm remodeling vascular endothelial cells agonist anti-cd40 antibody tumor-infiltrated macrophages depending tam-derived ccl17 related subjects cell lymphoma resistant pro-inflammatory m1 macrophages tams-derived tnf-α migration inhibitory factor tumor-infiltrated macrophages play full access cell-derived igs nuclear factor κb cd40-expressing solid tumors privacy choices/manage cookies independent prognostic factor cancer stem cells tam-derived pge2 cancer-related inflammation article yang

Questions {❓}

Is CD47 an innate immune checkpoint for tumor evasion?

Schema {🗺️}

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         headline:Tumor-associated macrophages: from basic research to clinical application
         description:The fact that various immune cells, including macrophages, can be found in tumor tissues has long been known. With the introduction of concept that macrophages differentiate into a classically or alternatively activated phenotype, the role of tumor-associated macrophages (TAMs) is now beginning to be elucidated. TAMs act as “protumoral macrophages,” contributing to disease progression. TAMs can promote initiation and metastasis of tumor cells, inhibit antitumor immune responses mediated by T cells, and stimulate tumor angiogenesis and subsequently tumor progression. As the relationship between TAMs and malignant tumors becomes clearer, TAMs are beginning to be seen as potential biomarkers for diagnosis and prognosis of cancers, as well as therapeutic targets in these cases. In this review, we will discuss the origin, polarization, and role of TAMs in human malignant tumors, as well as how TAMs can be used as diagnostic and prognostic biomarkers and therapeutic targets of cancer in clinics.
         datePublished:2017-02-28T00:00:00Z
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            Hematology
            Cancer Research
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ScholarlyArticle:
      headline:Tumor-associated macrophages: from basic research to clinical application
      description:The fact that various immune cells, including macrophages, can be found in tumor tissues has long been known. With the introduction of concept that macrophages differentiate into a classically or alternatively activated phenotype, the role of tumor-associated macrophages (TAMs) is now beginning to be elucidated. TAMs act as “protumoral macrophages,” contributing to disease progression. TAMs can promote initiation and metastasis of tumor cells, inhibit antitumor immune responses mediated by T cells, and stimulate tumor angiogenesis and subsequently tumor progression. As the relationship between TAMs and malignant tumors becomes clearer, TAMs are beginning to be seen as potential biomarkers for diagnosis and prognosis of cancers, as well as therapeutic targets in these cases. In this review, we will discuss the origin, polarization, and role of TAMs in human malignant tumors, as well as how TAMs can be used as diagnostic and prognostic biomarkers and therapeutic targets of cancer in clinics.
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         Tumor-associated macrophages (TAMs)
         Tumor microenvironment
         Protumoral activities
         Biomarker
         Therapeutic target
         Oncology
         Hematology
         Cancer Research
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      name:Yi Zhang
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               type:PostalAddress
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