We are analyzing https://link.springer.com/article/10.1186/s13045-019-0760-3.

Title:
Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications | Journal of Hematology & Oncology
Description:
Tumor metastasis is a major contributor to the death of cancer patients. It is driven not only by the intrinsic alterations in tumor cells, but also by the implicated cross-talk between cancer cells and their altered microenvironment components. Tumor-associated macrophages (TAMs) are the key cells that create an immunosuppressive tumor microenvironment (TME) by producing cytokines, chemokines, growth factors, and triggering the inhibitory immune checkpoint proteins release in T cells. In doing so, TAMs exhibit important functions in facilitating a metastatic cascade of cancer cells and, meanwhile, provide multiple targets of certain checkpoint blockade immunotherapies for opposing tumor progression. In this article, we summarize the regulating networks of TAM polarization and the mechanisms underlying TAM-facilitated metastasis. Based on the overview of current experimental evidence dissecting the critical roles of TAMs in tumor metastasis, we discuss and prospect the potential applications of TAM-focused therapeutic strategies in clinical cancer treatment at present and in the future.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

pubmed, article, google, scholar, tumor, cancer, cas, macrophages, metastasis, cells, tams, central, macrophage, cell, clinical, polarization, tumorassociated, growth, targeting, progression, breast, patients, receptor, tme, expression, res, wang, survival, tumors, oncol, immune, factor, angiogenesis, therapy, csf, microenvironment, mechanisms, ccl, chen, phenotype, immunol, therapeutic, regulation, signaling, zhang, factors, tam, agents, fig, study,

Topics {✒️}

tgf-beta-induced epithelial-mesenchymal transition tnf alpha-tnfr1-macrophage axis anti-csf-1r antibody reveals article download pdf macrophage colony-stimulating factor-1 colony-stimulating factor-1 receptor csf-1/csf-1r signaling axis tnf-related apoptosis-inducing ligand csf-1r-positive tam accumulation tumour-induced systemic environment tissue factor-mediated coagulation mitogen-activated protein kinase myeloid-derived suppressor cells innate anti-phagocytic axis cd47/sirp alpha axis egfr/akt/creb pathway treating skeletal-related events dictate organ-specific dissemination integrin-linked kinase activity sustained anti-tumor activities facilitate breast-tumour metastasis van der touw pro-inflammatory cytokines derived signal-regulatory protein alpha monocyte-dendritic cell progenitors pro-tumoral profile tam-targeted therapeutic solutions adenoma-linked barrier defects proangiogenic tie2-expressing monocytes tumor antigen-presenting behaviors early-stage breast cancer natural killer cell-dependent play multi-functional roles tumor cell-favoring direction tam-focused therapeutic strategies m2 macrophage-targeting peptide colony-stimulating factor-1 establishing pre-metastatic niches c-kit-mutated melanoma transforming growth factor-β inflammation-induced cell migration potential anti-cancer approaches median progression-free survival csf-1r expressing tams agonist monoclonal antibody impairing pro-tumoral functions pge2-elicited macrophage infiltration anti-ccl2 mab carlumab tissue-resident macrophage stem received official approval

Questions {❓}

Is CD47 an innate immune checkpoint for tumor evasion?
Therefore, there arises the tip of a far larger iceberg: what histology types or what cellular and molecular features in TME would benefit from TAM-targeted therapy?
Trabectedin mechanism of action: what’s new?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications
         description:Tumor metastasis is a major contributor to the death of cancer patients. It is driven not only by the intrinsic alterations in tumor cells, but also by the implicated cross-talk between cancer cells and their altered microenvironment components. Tumor-associated macrophages (TAMs) are the key cells that create an immunosuppressive tumor microenvironment (TME) by producing cytokines, chemokines, growth factors, and triggering the inhibitory immune checkpoint proteins release in T cells. In doing so, TAMs exhibit important functions in facilitating a metastatic cascade of cancer cells and, meanwhile, provide multiple targets of certain checkpoint blockade immunotherapies for opposing tumor progression. In this article, we summarize the regulating networks of TAM polarization and the mechanisms underlying TAM-facilitated metastasis. Based on the overview of current experimental evidence dissecting the critical roles of TAMs in tumor metastasis, we discuss and prospect the potential applications of TAM-focused therapeutic strategies in clinical cancer treatment at present and in the future.
         datePublished:2019-07-12T00:00:00Z
         dateModified:2019-07-12T00:00:00Z
         pageStart:1
         pageEnd:16
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s13045-019-0760-3
         keywords:
            Metastasis
            Macrophages
            TAMs
            TME
            Polarization
            Oncology
            Hematology
            Cancer Research
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-019-0760-3/MediaObjects/13045_2019_760_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-019-0760-3/MediaObjects/13045_2019_760_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-019-0760-3/MediaObjects/13045_2019_760_Fig3_HTML.png
         isPartOf:
            name:Journal of Hematology & Oncology
            issn:
               1756-8722
            volumeNumber:12
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Yuxin Lin
               affiliation:
                     name:Hospital of Chinese Medicine of Changxing County
                     address:
                        name:Department of Oncology, Hospital of Chinese Medicine of Changxing County, Huzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jianxin Xu
               affiliation:
                     name:Hospital of Chinese Medicine of Changxing County
                     address:
                        name:Department of Oncology, Hospital of Chinese Medicine of Changxing County, Huzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Huiyin Lan
               affiliation:
                     name:Zhejiang Cancer Hospital
                     address:
                        name:Department of Radiation Oncology, Zhejiang Key Lab of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China
                        type:PostalAddress
                     type:Organization
                     name:University of Michigan
                     address:
                        name:Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications
      description:Tumor metastasis is a major contributor to the death of cancer patients. It is driven not only by the intrinsic alterations in tumor cells, but also by the implicated cross-talk between cancer cells and their altered microenvironment components. Tumor-associated macrophages (TAMs) are the key cells that create an immunosuppressive tumor microenvironment (TME) by producing cytokines, chemokines, growth factors, and triggering the inhibitory immune checkpoint proteins release in T cells. In doing so, TAMs exhibit important functions in facilitating a metastatic cascade of cancer cells and, meanwhile, provide multiple targets of certain checkpoint blockade immunotherapies for opposing tumor progression. In this article, we summarize the regulating networks of TAM polarization and the mechanisms underlying TAM-facilitated metastasis. Based on the overview of current experimental evidence dissecting the critical roles of TAMs in tumor metastasis, we discuss and prospect the potential applications of TAM-focused therapeutic strategies in clinical cancer treatment at present and in the future.
      datePublished:2019-07-12T00:00:00Z
      dateModified:2019-07-12T00:00:00Z
      pageStart:1
      pageEnd:16
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s13045-019-0760-3
      keywords:
         Metastasis
         Macrophages
         TAMs
         TME
         Polarization
         Oncology
         Hematology
         Cancer Research
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-019-0760-3/MediaObjects/13045_2019_760_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-019-0760-3/MediaObjects/13045_2019_760_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-019-0760-3/MediaObjects/13045_2019_760_Fig3_HTML.png
      isPartOf:
         name:Journal of Hematology & Oncology
         issn:
            1756-8722
         volumeNumber:12
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yuxin Lin
            affiliation:
                  name:Hospital of Chinese Medicine of Changxing County
                  address:
                     name:Department of Oncology, Hospital of Chinese Medicine of Changxing County, Huzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jianxin Xu
            affiliation:
                  name:Hospital of Chinese Medicine of Changxing County
                  address:
                     name:Department of Oncology, Hospital of Chinese Medicine of Changxing County, Huzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Huiyin Lan
            affiliation:
                  name:Zhejiang Cancer Hospital
                  address:
                     name:Department of Radiation Oncology, Zhejiang Key Lab of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China
                     type:PostalAddress
                  type:Organization
                  name:University of Michigan
                  address:
                     name:Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Journal of Hematology & Oncology
      issn:
         1756-8722
      volumeNumber:12
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Hospital of Chinese Medicine of Changxing County
      address:
         name:Department of Oncology, Hospital of Chinese Medicine of Changxing County, Huzhou, China
         type:PostalAddress
      name:Hospital of Chinese Medicine of Changxing County
      address:
         name:Department of Oncology, Hospital of Chinese Medicine of Changxing County, Huzhou, China
         type:PostalAddress
      name:Zhejiang Cancer Hospital
      address:
         name:Department of Radiation Oncology, Zhejiang Key Lab of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China
         type:PostalAddress
      name:University of Michigan
      address:
         name:Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Yuxin Lin
      affiliation:
            name:Hospital of Chinese Medicine of Changxing County
            address:
               name:Department of Oncology, Hospital of Chinese Medicine of Changxing County, Huzhou, China
               type:PostalAddress
            type:Organization
      name:Jianxin Xu
      affiliation:
            name:Hospital of Chinese Medicine of Changxing County
            address:
               name:Department of Oncology, Hospital of Chinese Medicine of Changxing County, Huzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Huiyin Lan
      affiliation:
            name:Zhejiang Cancer Hospital
            address:
               name:Department of Radiation Oncology, Zhejiang Key Lab of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:University of Michigan
            address:
               name:Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Oncology, Hospital of Chinese Medicine of Changxing County, Huzhou, China
      name:Department of Oncology, Hospital of Chinese Medicine of Changxing County, Huzhou, China
      name:Department of Radiation Oncology, Zhejiang Key Lab of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China
      name:Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, USA

External Links {🔗}(590)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

6.06s.

LINK . SPRINGER . COM {}