We are analyzing https://link.springer.com/article/10.1007/s00011-020-01378-2.

Title:
Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome | Inflammation Research
Description:
Purpose Macrophages are highly plastic cells. Under different stimuli, macrophages can be polarized into several different subsets. Two main macrophage subsets have been suggested: classically activated or inflammatory (M1) macrophages and alternatively activated or anti-inflammatory (M2) macrophages. Macrophage polarization is governed by a highly complex set of regulatory networks. Many recent studies have shown that macrophages are key orchestrators in the pathogenesis of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and that regulation of macrophage polarization may improve the prognosis of ALI/ARDS. A further understanding of the mechanisms of macrophage polarization is expected to be helpful in the development of novel therapeutic targets to treat ALI/ARDS. Therefore, we performed a literature review to summarize the regulatory mechanisms of macrophage polarization and its role in the pathogenesis of ALI/ARDS. Methods A computer-based online search was performed using the PubMed database and Web of Science database for published articles concerning macrophages, macrophage polarization, and ALI/ARDS. Results In this review, we discuss the origin, polarization, and polarization regulation of macrophages as well as the role of macrophage polarization in various stages of ARDS. According to the current literature, regulating the polarized state of macrophages might be a potential therapeutic strategy against ALI/ARDS.
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Topics {✒️}

bone marrow-derived monocyte/macrophage ventilator-induced lung injury rsv-induced lung injury lipopolysaccharide-induced inflammatory response d'alessio fr acute lung injury computer-based online search polycomb-mediated gene silencing month download article/chapter jmjd3-irf4 axis diet-induced obese rats tgf-β induces m2 macrophage profile glucose-loaded murine macrophages 5-induced lung inflammation interleukin-13-regulated m2 macrophages tissue-resident macrophage ontogeny acute exercise induces lipopolysaccharide-induced cytokine zhihai han lung macrophage subpopulations pro-inflammatory m1 macrophages related subjects regulating m1 polarization gts-21 reduces inflammation enhances il-10 production macrophage-lineage cells lung macrophage diversity experimental acute pancreatitis jak-stat signaling pathway jnk/stat3 signaling pathway tlr-mediated innate immunity chronic fibrosis induced pulmonary macrophage subpopulations full article pdf pro-inflammatory phenotype stat6 transcription factor privacy choices/manage cookies stem cells modulating macrophage polarization highly plastic cells interleukin-4-dependent production gene expression profiling tgf-β signaling ampk-pparγ pathway tgf-β activation itam-dependent pathways immune cell signaling snail-mediated suppression gm-csf influence

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