We are analyzing https://link.springer.com/article/10.1007/s00281-020-00798-w.

Title:
Immunometabolism: new insights and lessons from antigen-directed cellular immune responses | Seminars in Immunopathology
Description:
Modulation of immune responses by nutrients is an important area of study in cellular biology and clinical sciences in the context of cancer therapies and anti-pathogen-directed immune responses in health and disease. We review metabolic pathways that influence immune cell function and cellular persistence in chronic infections. We also highlight the role of nutrients in altering the tissue microenvironment with lessons from the tumor microenvironment that shapes the quality and quantity of cellular immune responses. Multiple layers of biological networks, including the nature of nutritional supplements, the genetic background, previous exposures, and gut microbiota status have impact on cellular performance and immune competence against molecularly defined targets. We discuss how immune metabolism determines the differentiation pathway of antigen-specific immune cells and how these insights can be explored to devise better strategies to strengthen anti-pathogen-directed immune responses, while curbing unwanted, non-productive inflammation.
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28 years and 1 months (reg. 1997-05-29).

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Topics {✒️}

month download article/chapter proatherogenic metabolite trimethylamine-n-oxide anti-pathogen-directed immune responses palsson-mcdermott em transforming growth factor-beta branched-chain amino acid kinases tbk1-ikkvarepsilon supports cell receptor zeta-chain hif-1alpha-mediated aerobic glycolysis inducing pmn-mdsc infiltration epa-enriched nutritional supplement myeloid-derived suppressor cells lysine-fortified wheat flour poor peri-urban households de aguilar-nascimento je reactive oxygen species fatty acid-induced inflammation therapeutic anti-vegf antibodies multiplex cytokine analysis mtorc2-irf4 signaling axis promising anti-cancer approach platinum-induced muscle wasting fish oil supplementation chemotherapy-induced musculoskeletal degradation m2-polarized macrophages synergize assessing tumor-infiltrating lymphocytes forward host-directed therapies prisma-compliant meta-analysis fatty acid oxidation placebo-controlled intervention trial full article pdf short-term parenteral nutrition pyruvate kinase m2 antigen-specific immune cells immune-mediated antitumor effect antigen receptor-mediated al-khami aa pyruvate dehydrogenase kinase cancer-induced muscle wasting chemotherapy-induced muscle wasting multicenter cross-sectional study acetate/acetyl-coa metabolism vander heiden mg giuseppe ippolito randomized double-blind trial cancer-induced cardiac cachexia leucine deprivation reveals omega-3 fatty acid tissue-resident memory cd8 innate immune responses

Questions {❓}

Grimble G (1994) Can daily dietary arginine supplement affect the function and subpopulation of lymphocytes in patients with advanced gastric cancer?
Sikalidis AK (2015) Amino acids and immune response: a role for cysteine, glutamine, phenylalanine, tryptophan and arginine in T-cell function and cancer?
Van den Bossche J, O’Neill LA, Menon D (2017) Macrophage immunometabolism: where are we (going)?

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