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Title:
Research progress on Toll-like receptor signal transduction and its roles in antimicrobial immune responses | Applied Microbiology and Biotechnology
Description:
When microorganisms invade a host, the innate immune system first recognizes the pathogen-associated molecular patterns of these microorganisms through pattern recognition receptors (PRRs). Toll-like receptors (TLRs) are known transmembrane PRRs existing in both invertebrates and vertebrates. Upon ligand recognition, TLRs initiate a cascade of signaling events; promote the pro-inflammatory cytokine, type I interferon, and chemokine expression; and play an essential role in the modulation of the host’s innate and adaptive immunity. Therefore, it is of great significance to improve our understanding of antimicrobial immune responses by studying the role of TLRs and their signal molecules in the host’s defense against invading microbes. This paper aims to summarize the specificity of TLRs in recognition of conserved microbial components, such as lipoprotein, lipopolysaccharide, flagella, endosomal nucleic acids, and other bioactive metabolites derived from microbes. This set of interactions helps to elucidate the immunomodulatory effect of TLRs and the signal transduction changes involved in the infectious process and provide a novel therapeutic strategy to combat microbial infections.
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Keywords {🔍}
pubmed, article, google, scholar, cas, central, tlr, tolllike, immunol, receptor, signaling, cell, innate, receptors, immune, immunity, biol, microbiol, responses, recognition, wang, zhu, host, cells, xia, bacterial, zhang, lee, mol, rev, sci, activation, nat, infection, lps, human, signal, liu, httpsdoiorgjimmunol, research, role, plos, pathog, virus, rna, httpsdoiorgs, yang, van, structural, tlrs,
Topics {✒️}
tak1/tab1/tab2/tab3 complex anti-inflammatory pattern-recognition receptor fine-tuning tlr-7-based therapy lps-induced pro-inflammatory signaling month download article/chapter macrophage-mediated inflammatory responses unique anti-inflammatory properties virus-induced acute pneumonia dsrna-bound tlr3 complex n-terminal d1 domain short-chain fatty acids tak-1/jnk/ap-1 pathways article applied microbiology methicillin-resistant staphylococcus aureus nf-κb signaling pathways hiv-1-infected autologous cd4+ cpg-oligodeoxynucleotides stimulate immunoglobulin inflammation-induced immunoregulatory metabolite hsv-1/tlr9-mediated ifnβ small-cell lung cancer ipec-j2 cell model tlr1-tlr2 heterodimer induced influenza-induced immune suppression t4ss-dependent tlr5 activation regulates il-8 expression full article pdf related subjects nk cell-mediated inhibition netea mg nf-κb pathways antimicrobial immune responses pattern recognition receptors epithelial immune responses 4-induced nf-{kappa} endosomal pattern recognition pro-inflammatory cytokine mycobacterium tuberculosis innate antimicrobial responses tlr8 differentially activate intestinal epithelial cells lps-host cell interactions anti-inflammatory effects enhances hiv-1 transcription privacy choices/manage cookies lps binding protein pro-inflammatory interleukins host immune responses gpr109a dependent mechanisms pk-15 cells mediated staphylococcus aureus infection
Questions {❓}
- Brencicova E, Diebold S (2013) Nucleic acids and endosomal pattern recognition: how to tell friend from foe?
- Hennessy EJ, Parker AE, O'Neill LAJ (2010) Targeting Toll-like receptors: emerging therapeutics?
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name:Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China
name:Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou, China
name:College of Veterinary Medicine (Institute of Comparative Medicine), Yangzhou University, Yangzhou, China
name:Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China
name:Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou, China
name:College of Veterinary Medicine (Institute of Comparative Medicine), Yangzhou University, Yangzhou, China
name:Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China
name:Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou, China
name:College of Veterinary Medicine (Institute of Comparative Medicine), Yangzhou University, Yangzhou, China
name:Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China
name:Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou, China
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