
NCBI . NLM . NIH . GOV {
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Title[redir]:
Durable antitumor responses to CD47 blockade require adaptive immune stimulation - PMC
Description:
Therapeutic antitumor antibodies are widely used clinically. CD47 is an antiphagocytic ligand expressed by tumors that binds the inhibitory receptor signal regulatory protein alpha (SIRPα) on phagocytic cells. Interruption of CD47–SIRPα interactions ...
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Keywords {🔍}
cells, tumor, mouse, doi, fig, antibody, cell, mice, human, phagocytosis, antipdl, antitumor, anticd, pubmed, google, scholar, immune, combination, blockade, antibodies, binding, pmc, tumors, therapy, free, article, cancer, macrophage, control, nanobody, adaptive, sirpα, efficacy, treatment, pdl, antimouse, data, model, adcp, innate, vitro, syngeneic, treated, therapeutic, models, macrophages, antagonist, response, antagonism, tcell,
Topics {✒️}
pcdh-cmv-msc-efi-puro granulocyte/macrophage colony-stimulating factor anti-her2/neu antibody depends ifn-γ-inducible immunosuppressive factor anti–pd-l1 partially rescues bone marrow-derived balb/ pd-1/pd-l1 axis reinvigorates anti–pd-l1 blocking mabs pd-l1–expressing tumor cells gm-csf–secreting b16f10 cells pd-l1/pd-1 immunosuppressive pathways anti-mouse cd47-blocking nanobody anti–pd-l1 antibodies warrants anti–pd-l1 antibodies failed cd47-signal regulatory protein-α anti–pd-l1 blocking antibody tumor-specific t-cell responses immunomodulatory anti–pd-l1 antibody anti-cd47 antibody-mediated phagocytosis anti–pd-l1 blocking antibodies blocking pd-1/pd-l1 signaling anti–trp-1 mab-mediated phagocytosis remove free nhs-biotin pd-l1–positive b16f10 cells c-terminal sortase motif prime t-cell responses engulfed cfse-positive ct26mcd200 inhibits macrophage-mediated adcp ifn-γ–treated b16f10 cells signal-regulatory protein alpha t-cell checkpoint antibodies signal-regulatory protein α antitumor t-cell responses myone streptavidin-t1 dynabeads anti–pd-l1 mabs resist macrophage-mediated adcp t-cell checkpoint blockade antitumor t-cell response c57bl/6j mice bearing anti-mouse cd47 nanobody pd-1/pd-l1 axis org/lookup/suppl/doi anti–pd-l1 survivors syngeneic b16-f10 tumors anti-mouse f4/80-apc anti–pd-l1 antibody anti-mouse cd47 antibody antibody-dependent tumor cell anti–pd-l1 mab pd-l1 blockade potentiates
Questions {❓}
- These results raise an important question: Will anti-CD47 monotherapy or combination therapy with antitumor antibodies be as successful in the clinic as in preclinical human tumor xenograft models?
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