We are analyzing https://link.springer.com/article/10.1186/s13046-018-0876-2.

Title:
Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through β-catenin/Erk/Akt signaling in gastric cancer | Journal of Experimental & Clinical Cancer Research
Description:
Background Enzymatically inactive chitinase-like protein CHI3L1 drives inflammatory response and promotes tumor progression. However, its role in gastric cancer (GC) tumorigenesis and metastasis has not yet been fully elucidated. We determined the significance of CHI3L1 expression in patients with GC. We also explored an as-yet unknown receptor of CHI3L1 and investigated the involved signaling in GC metastasis. Methods CHI3L1 expression was evaluated by immunoblotting, tissue microarray-based immunohistochemistry analysis (n = 100), and enzyme linked immunosorbent assay (ELISA) (n = 150). The interactions between CD44 and CHI3L1 or Interleukin-13 receptor alpha 2 (IL-13Rα2) were analyzed by co-immunoprecipitation, immunofluorescence co-localization assay, ELISA, and bio-layer interferometry. The roles of CHI3L1/CD44 axis in GC metastasis were investigated in GC cell lines and experimental animal model by gain and loss of function. Results CHI3L1 upregulation occurred during GC development, and positively correlated with GC invasion depth, lymph node status, and tumor staging. Mechanically, CHI3L1 binding to CD44 activated Erk and Akt, along with β-catenin signaling by phosphorylating β-catenin at Ser552 and Ser675. CD44 also interacted with IL-13Rα2 to form a complex. Notably, CD44v3 peptide and protein, but not CD44v6 peptide or CD44s protein, bound to both CHI3L1 and IL-13Rα2. Our in vivo and in vitro data further demonstrated that CHI3L1 promoted GC cell proliferation, migration, and metastasis. Conclusions CHI3L1 binding to CD44v3 activates Erk, Akt, and β-catenin signaling, therefore enhances GC metastasis. CHI3L1 expression is a novel biomarker for the prognosis of GC, and these findings have thus identified CHI3L1/CD44 axis as a vital pathway and potential therapeutic target in GC.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,626,432 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We find it hard to spot revenue streams.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

chil, cells, pubmed, article, metastasis, google, scholar, cancer, cas, cell, tumor, ilrα, cdv, fig, signaling, data, expression, ags, antibody, receptor, mice, patients, assay, invasion, central, gastric, mgc, protein, shown, activation, rhchil, analysis, βcatenin, ecd, binding, peptide, serum, control, growth, tissues, nanjing, china, erk, human, akt, progression, role, significantly, medical, lung,

Topics {✒️}

optimal ser-gly-ser-gly beta-catenin/tcf signaling pathway chi3l1/cd44/il-13rα2 axis regulates wnt/β-catenin signaling pathway wnt/β-catenin signaling pathways chi3l1/cd44-il-13rα2 signaling pathway wnt/β-catenin inhibitor icg001 cancer-related mortality worldwide emt-inducing transcription factors article download pdf β-catenin/erk/akt signaling wnt/β-catenin pathway bone marrow-derived macrophages evaluate β-catenin phosphorylation wnt/β-catenin signaling [19] wnt/β-catenin signaling β-catenin signaling pathways eralpha-negative breast cancer poly-lysine-coated coverslips b16-f10 melanoma cells dela cruz cs grant numbers kycx17_1291/jx22013442 chi3l1/cd44 signaling governs lenti-shcontrol-transfected mgc803 cells tgf-beta family signaling mouse tgf-β1 levels nuclear β-catenin staining external n-terminal region heparin-binding growth factor facilitate e-cadherin loss chi3l1/cd44 axis serves il-13rα2 utilizes tmem219 enhance anti-tumor immunity orian-rousseau activated tgf-β1 il-13rα2 signaling requires membrane-bound protein syndecan-1 pi3k/akt/mtor pathways high-level chi3l1 expression il-13-induced tissue responses anti-il-13rα2 antibody th1/th2 inflammatory balance key downstream targets broncho-alveolar lavage hermansky-pudlak syndrome gastrointestinal cancer il-13rα2 induces wnt/β-catenin il-13rα2-dependent mechanism β-catenin pathway

Questions {❓}

Is YKL-40 a new therapeutic target in cancer?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through β-catenin/Erk/Akt signaling in gastric cancer
         description:Enzymatically inactive chitinase-like protein CHI3L1 drives inflammatory response and promotes tumor progression. However, its role in gastric cancer (GC) tumorigenesis and metastasis has not yet been fully elucidated. We determined the significance of CHI3L1 expression in patients with GC. We also explored an as-yet unknown receptor of CHI3L1 and investigated the involved signaling in GC metastasis. CHI3L1 expression was evaluated by immunoblotting, tissue microarray-based immunohistochemistry analysis (n = 100), and enzyme linked immunosorbent assay (ELISA) (n = 150). The interactions between CD44 and CHI3L1 or Interleukin-13 receptor alpha 2 (IL-13Rα2) were analyzed by co-immunoprecipitation, immunofluorescence co-localization assay, ELISA, and bio-layer interferometry. The roles of CHI3L1/CD44 axis in GC metastasis were investigated in GC cell lines and experimental animal model by gain and loss of function. CHI3L1 upregulation occurred during GC development, and positively correlated with GC invasion depth, lymph node status, and tumor staging. Mechanically, CHI3L1 binding to CD44 activated Erk and Akt, along with β-catenin signaling by phosphorylating β-catenin at Ser552 and Ser675. CD44 also interacted with IL-13Rα2 to form a complex. Notably, CD44v3 peptide and protein, but not CD44v6 peptide or CD44s protein, bound to both CHI3L1 and IL-13Rα2. Our in vivo and in vitro data further demonstrated that CHI3L1 promoted GC cell proliferation, migration, and metastasis. CHI3L1 binding to CD44v3 activates Erk, Akt, and β-catenin signaling, therefore enhances GC metastasis. CHI3L1 expression is a novel biomarker for the prognosis of GC, and these findings have thus identified CHI3L1/CD44 axis as a vital pathway and potential therapeutic target in GC.
         datePublished:2018-08-30T00:00:00Z
         dateModified:2018-08-30T00:00:00Z
         pageStart:1
         pageEnd:20
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s13046-018-0876-2
         keywords:
            CHI3L1
            CD44
            IL-13Rα2
            β-Catenin
            Gastric Cancer
            Cancer Research
            Immunology
            Apoptosis
            Oncology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13046-018-0876-2/MediaObjects/13046_2018_876_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13046-018-0876-2/MediaObjects/13046_2018_876_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13046-018-0876-2/MediaObjects/13046_2018_876_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13046-018-0876-2/MediaObjects/13046_2018_876_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13046-018-0876-2/MediaObjects/13046_2018_876_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13046-018-0876-2/MediaObjects/13046_2018_876_Fig6_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13046-018-0876-2/MediaObjects/13046_2018_876_Fig7_HTML.png
         isPartOf:
            name:Journal of Experimental & Clinical Cancer Research
            issn:
               1756-9966
            volumeNumber:37
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Biao Geng
               affiliation:
                     name:Second Affiliated Hospital, Nanjing Medical University
                     address:
                        name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
                     name:Yijishan Hospital, Wannan Medical College
                     address:
                        name:Department of Respiratory Medicine, Yijishan Hospital, Wannan Medical College, Wuhu, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jinshun Pan
               affiliation:
                     name:Second Affiliated Hospital, Nanjing Medical University
                     address:
                        name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ting Zhao
               affiliation:
                     name:Second Affiliated Hospital, Nanjing Medical University
                     address:
                        name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jie Ji
               affiliation:
                     name:First Clinical Medical College of Nanjing Medical University
                     address:
                        name:First Clinical Medical College of Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chen Zhang
               affiliation:
                     name:Second Affiliated Hospital, Nanjing Medical University
                     address:
                        name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ying Che
               affiliation:
                     name:Second Affiliated Hospital, Nanjing Medical University
                     address:
                        name:Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jing Yang
               affiliation:
                     name:Second Affiliated Hospital, Nanjing Medical University
                     address:
                        name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hui Shi
               affiliation:
                     name:Affiliated Hospital of Nantong University
                     address:
                        name:Department of Thoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Juan Li
               affiliation:
                     name:Second Affiliated Hospital, Nanjing Medical University
                     address:
                        name:Cancer Medical Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hong Zhou
               affiliation:
                     name:Nanjing Medical University
                     address:
                        name:Department of Immunology, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xianmin Mu
               affiliation:
                     name:Second Affiliated Hospital, Nanjing Medical University
                     address:
                        name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Che Xu
               affiliation:
                     name:Second Affiliated Hospital, Nanjing Medical University
                     address:
                        name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chao Wang
               affiliation:
                     name:Second Affiliated Hospital, Nanjing Medical University
                     address:
                        name:Department of Surgery, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yue Xu
               affiliation:
                     name:Second Affiliated Hospital, Nanjing Medical University
                     address:
                        name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zheng Liu
               affiliation:
                     name:Second Affiliated Hospital, Nanjing Medical University
                     address:
                        name:Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hao Wen
               affiliation:
                     name:Second Affiliated Hospital, Nanjing Medical University
                     address:
                        name:Department of Surgery, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Qiang You
               url:http://orcid.org/0000-0003-3308-4127
               affiliation:
                     name:Second Affiliated Hospital, Nanjing Medical University
                     address:
                        name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
                     name:Second Affiliated Hospital, Nanjing Medical University
                     address:
                        name:Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
                     name:Second Affiliated Hospital, Nanjing Medical University
                     address:
                        name:Cancer Medical Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
                     name:Nanjing Medical University
                     address:
                        name:Department of Immunology, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
                     name:Nanjing Medical University
                     address:
                        name:Key Laboratory for Aging & Disease, Nanjing Medical University, Nanjing, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through β-catenin/Erk/Akt signaling in gastric cancer
      description:Enzymatically inactive chitinase-like protein CHI3L1 drives inflammatory response and promotes tumor progression. However, its role in gastric cancer (GC) tumorigenesis and metastasis has not yet been fully elucidated. We determined the significance of CHI3L1 expression in patients with GC. We also explored an as-yet unknown receptor of CHI3L1 and investigated the involved signaling in GC metastasis. CHI3L1 expression was evaluated by immunoblotting, tissue microarray-based immunohistochemistry analysis (n = 100), and enzyme linked immunosorbent assay (ELISA) (n = 150). The interactions between CD44 and CHI3L1 or Interleukin-13 receptor alpha 2 (IL-13Rα2) were analyzed by co-immunoprecipitation, immunofluorescence co-localization assay, ELISA, and bio-layer interferometry. The roles of CHI3L1/CD44 axis in GC metastasis were investigated in GC cell lines and experimental animal model by gain and loss of function. CHI3L1 upregulation occurred during GC development, and positively correlated with GC invasion depth, lymph node status, and tumor staging. Mechanically, CHI3L1 binding to CD44 activated Erk and Akt, along with β-catenin signaling by phosphorylating β-catenin at Ser552 and Ser675. CD44 also interacted with IL-13Rα2 to form a complex. Notably, CD44v3 peptide and protein, but not CD44v6 peptide or CD44s protein, bound to both CHI3L1 and IL-13Rα2. Our in vivo and in vitro data further demonstrated that CHI3L1 promoted GC cell proliferation, migration, and metastasis. CHI3L1 binding to CD44v3 activates Erk, Akt, and β-catenin signaling, therefore enhances GC metastasis. CHI3L1 expression is a novel biomarker for the prognosis of GC, and these findings have thus identified CHI3L1/CD44 axis as a vital pathway and potential therapeutic target in GC.
      datePublished:2018-08-30T00:00:00Z
      dateModified:2018-08-30T00:00:00Z
      pageStart:1
      pageEnd:20
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s13046-018-0876-2
      keywords:
         CHI3L1
         CD44
         IL-13Rα2
         β-Catenin
         Gastric Cancer
         Cancer Research
         Immunology
         Apoptosis
         Oncology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13046-018-0876-2/MediaObjects/13046_2018_876_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13046-018-0876-2/MediaObjects/13046_2018_876_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13046-018-0876-2/MediaObjects/13046_2018_876_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13046-018-0876-2/MediaObjects/13046_2018_876_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13046-018-0876-2/MediaObjects/13046_2018_876_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13046-018-0876-2/MediaObjects/13046_2018_876_Fig6_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13046-018-0876-2/MediaObjects/13046_2018_876_Fig7_HTML.png
      isPartOf:
         name:Journal of Experimental & Clinical Cancer Research
         issn:
            1756-9966
         volumeNumber:37
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Biao Geng
            affiliation:
                  name:Second Affiliated Hospital, Nanjing Medical University
                  address:
                     name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
                  name:Yijishan Hospital, Wannan Medical College
                  address:
                     name:Department of Respiratory Medicine, Yijishan Hospital, Wannan Medical College, Wuhu, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jinshun Pan
            affiliation:
                  name:Second Affiliated Hospital, Nanjing Medical University
                  address:
                     name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ting Zhao
            affiliation:
                  name:Second Affiliated Hospital, Nanjing Medical University
                  address:
                     name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jie Ji
            affiliation:
                  name:First Clinical Medical College of Nanjing Medical University
                  address:
                     name:First Clinical Medical College of Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chen Zhang
            affiliation:
                  name:Second Affiliated Hospital, Nanjing Medical University
                  address:
                     name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ying Che
            affiliation:
                  name:Second Affiliated Hospital, Nanjing Medical University
                  address:
                     name:Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jing Yang
            affiliation:
                  name:Second Affiliated Hospital, Nanjing Medical University
                  address:
                     name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hui Shi
            affiliation:
                  name:Affiliated Hospital of Nantong University
                  address:
                     name:Department of Thoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Juan Li
            affiliation:
                  name:Second Affiliated Hospital, Nanjing Medical University
                  address:
                     name:Cancer Medical Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hong Zhou
            affiliation:
                  name:Nanjing Medical University
                  address:
                     name:Department of Immunology, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xianmin Mu
            affiliation:
                  name:Second Affiliated Hospital, Nanjing Medical University
                  address:
                     name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Che Xu
            affiliation:
                  name:Second Affiliated Hospital, Nanjing Medical University
                  address:
                     name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chao Wang
            affiliation:
                  name:Second Affiliated Hospital, Nanjing Medical University
                  address:
                     name:Department of Surgery, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yue Xu
            affiliation:
                  name:Second Affiliated Hospital, Nanjing Medical University
                  address:
                     name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zheng Liu
            affiliation:
                  name:Second Affiliated Hospital, Nanjing Medical University
                  address:
                     name:Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hao Wen
            affiliation:
                  name:Second Affiliated Hospital, Nanjing Medical University
                  address:
                     name:Department of Surgery, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Qiang You
            url:http://orcid.org/0000-0003-3308-4127
            affiliation:
                  name:Second Affiliated Hospital, Nanjing Medical University
                  address:
                     name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
                  name:Second Affiliated Hospital, Nanjing Medical University
                  address:
                     name:Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
                  name:Second Affiliated Hospital, Nanjing Medical University
                  address:
                     name:Cancer Medical Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
                  name:Nanjing Medical University
                  address:
                     name:Department of Immunology, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
                  name:Nanjing Medical University
                  address:
                     name:Key Laboratory for Aging & Disease, Nanjing Medical University, Nanjing, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Journal of Experimental & Clinical Cancer Research
      issn:
         1756-9966
      volumeNumber:37
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Second Affiliated Hospital, Nanjing Medical University
      address:
         name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Yijishan Hospital, Wannan Medical College
      address:
         name:Department of Respiratory Medicine, Yijishan Hospital, Wannan Medical College, Wuhu, China
         type:PostalAddress
      name:Second Affiliated Hospital, Nanjing Medical University
      address:
         name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Second Affiliated Hospital, Nanjing Medical University
      address:
         name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:First Clinical Medical College of Nanjing Medical University
      address:
         name:First Clinical Medical College of Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Second Affiliated Hospital, Nanjing Medical University
      address:
         name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Second Affiliated Hospital, Nanjing Medical University
      address:
         name:Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Second Affiliated Hospital, Nanjing Medical University
      address:
         name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Affiliated Hospital of Nantong University
      address:
         name:Department of Thoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China
         type:PostalAddress
      name:Second Affiliated Hospital, Nanjing Medical University
      address:
         name:Cancer Medical Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Nanjing Medical University
      address:
         name:Department of Immunology, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Second Affiliated Hospital, Nanjing Medical University
      address:
         name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Second Affiliated Hospital, Nanjing Medical University
      address:
         name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Second Affiliated Hospital, Nanjing Medical University
      address:
         name:Department of Surgery, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Second Affiliated Hospital, Nanjing Medical University
      address:
         name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Second Affiliated Hospital, Nanjing Medical University
      address:
         name:Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Second Affiliated Hospital, Nanjing Medical University
      address:
         name:Department of Surgery, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Second Affiliated Hospital, Nanjing Medical University
      address:
         name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Second Affiliated Hospital, Nanjing Medical University
      address:
         name:Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Second Affiliated Hospital, Nanjing Medical University
      address:
         name:Cancer Medical Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Nanjing Medical University
      address:
         name:Department of Immunology, Nanjing Medical University, Nanjing, China
         type:PostalAddress
      name:Nanjing Medical University
      address:
         name:Key Laboratory for Aging & Disease, Nanjing Medical University, Nanjing, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Biao Geng
      affiliation:
            name:Second Affiliated Hospital, Nanjing Medical University
            address:
               name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
            name:Yijishan Hospital, Wannan Medical College
            address:
               name:Department of Respiratory Medicine, Yijishan Hospital, Wannan Medical College, Wuhu, China
               type:PostalAddress
            type:Organization
      name:Jinshun Pan
      affiliation:
            name:Second Affiliated Hospital, Nanjing Medical University
            address:
               name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Ting Zhao
      affiliation:
            name:Second Affiliated Hospital, Nanjing Medical University
            address:
               name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Jie Ji
      affiliation:
            name:First Clinical Medical College of Nanjing Medical University
            address:
               name:First Clinical Medical College of Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Chen Zhang
      affiliation:
            name:Second Affiliated Hospital, Nanjing Medical University
            address:
               name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Ying Che
      affiliation:
            name:Second Affiliated Hospital, Nanjing Medical University
            address:
               name:Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Jing Yang
      affiliation:
            name:Second Affiliated Hospital, Nanjing Medical University
            address:
               name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Hui Shi
      affiliation:
            name:Affiliated Hospital of Nantong University
            address:
               name:Department of Thoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China
               type:PostalAddress
            type:Organization
      name:Juan Li
      affiliation:
            name:Second Affiliated Hospital, Nanjing Medical University
            address:
               name:Cancer Medical Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Hong Zhou
      affiliation:
            name:Nanjing Medical University
            address:
               name:Department of Immunology, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Xianmin Mu
      affiliation:
            name:Second Affiliated Hospital, Nanjing Medical University
            address:
               name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Che Xu
      affiliation:
            name:Second Affiliated Hospital, Nanjing Medical University
            address:
               name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Chao Wang
      affiliation:
            name:Second Affiliated Hospital, Nanjing Medical University
            address:
               name:Department of Surgery, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Yue Xu
      affiliation:
            name:Second Affiliated Hospital, Nanjing Medical University
            address:
               name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Zheng Liu
      affiliation:
            name:Second Affiliated Hospital, Nanjing Medical University
            address:
               name:Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Hao Wen
      affiliation:
            name:Second Affiliated Hospital, Nanjing Medical University
            address:
               name:Department of Surgery, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Qiang You
      url:http://orcid.org/0000-0003-3308-4127
      affiliation:
            name:Second Affiliated Hospital, Nanjing Medical University
            address:
               name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
            name:Second Affiliated Hospital, Nanjing Medical University
            address:
               name:Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
            name:Second Affiliated Hospital, Nanjing Medical University
            address:
               name:Cancer Medical Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
            name:Nanjing Medical University
            address:
               name:Department of Immunology, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
            name:Nanjing Medical University
            address:
               name:Key Laboratory for Aging & Disease, Nanjing Medical University, Nanjing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
      name:Department of Respiratory Medicine, Yijishan Hospital, Wannan Medical College, Wuhu, China
      name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
      name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
      name:First Clinical Medical College of Nanjing Medical University, Nanjing, China
      name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
      name:Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
      name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
      name:Department of Thoracic Surgery, Affiliated Hospital of Nantong University, Nantong, China
      name:Cancer Medical Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
      name:Department of Immunology, Nanjing Medical University, Nanjing, China
      name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
      name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
      name:Department of Surgery, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
      name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
      name:Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
      name:Department of Surgery, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
      name:Department of Biotherapy, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
      name:Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
      name:Cancer Medical Center, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
      name:Department of Immunology, Nanjing Medical University, Nanjing, China
      name:Key Laboratory for Aging & Disease, Nanjing Medical University, Nanjing, China

External Links {🔗}(272)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref
Pbgrd

5.12s.

LINK . SPRINGER . COM {}