We are analyzing https://link.springer.com/article/10.1186/s12979-021-00215-2.

Title:
Macrophage function in the elderly and impact on injury repair and cancer | Immunity & Ageing
Description:
Older age is associated with deteriorating health, including escalating risk of diseases such as cancer, and a diminished ability to repair following injury. This rise in age-related diseases/co-morbidities is associated with changes to immune function, including in myeloid cells, and is related to immunosenescence. Immunosenescence reflects age-related changes associated with immune dysfunction and is accompanied by low-grade chronic inflammation or inflammageing. This is characterised by increased levels of circulating pro-inflammatory cytokines such as tumor necrosis factor (TNF), interleukin (IL)-1β and IL-6. However, in healthy ageing, there is a concomitant age-related escalation in anti-inflammatory cytokines such as transforming growth factor-β1 (TGF-β1) and IL-10, which may overcompensate to regulate the pro-inflammatory state. Key inflammatory cells, macrophages, play a role in cancer development and injury repair in young hosts, and we propose that their role in ageing in these scenarios may be more profound. Imbalanced pro- and anti-inflammatory factors during ageing may also have a significant influence on macrophage function and further impact the severity of age-related diseases in which macrophages are known to play a key role. In this brief review we summarise studies describing changes to inflammatory function of macrophages (from various tissues and across sexes) during healthy ageing. We also describe age-related diseases/co-morbidities where macrophages are known to play a key role, focussed on injury repair processes and cancer, plus comment briefly on strategies to correct for these age-related changes.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, article, macrophages, google, scholar, cas, central, mice, cells, macrophage, ageing, cell, aged, elderly, function, cancer, aging, immunol, immune, studies, injury, tumor, agerelated, young, muscle, proinflammatory, repair, inflammatory, cblj, months, response, tissue, female, increased, monocytes, mdscs, bone, responses, inflammation, factors, humans, shown, skeletal, immunity, impact, increase, healthy, growth, role, due,

Topics {✒️}

young serum/plasma/blood products diet-induced murine steatohepatitis article download pdf female c57bl/6j mice c57bl/6j female mice chronic age-related diseases c57bl/6j geriatric mice describe age-related diseases/ female c57bl/6n mice muscle-derived nitric oxide aged c57bl/6j mice tumor-bearing mice led bone marrow-derived monocytes/macrophages myeloid-derived suppressor cell serum/plasma/blood products concomitant age-related escalation age-related thymic involution myeloid‐derived suppressor cells myeloid-derived suppressor cells pre-activated basal state interferon-gamma inducible protein-10 young tumor-bearing mice low-grade chronic inflammation transforming growth factor-β1 macrophage-specific scavenger receptor nf-kappab-dependent mechanism hif-1alpha regulates function reflecting age-related differences older hip-fracture patients bone marrow-derived macrophages bone-marrow derived macrophages brain-resident microglial populations van den bossche circulating pro-inflammatory cytokines reduces treatment-induced cachexia tumor necrosis factor janus kinase/signal transducers targeting macrophage-recruiting chemokines bone-fracture healing model injury-induced microglia behavior c57bl/6j mice pro-resolving monocyte/macrophages reduced anti-oxidative defense age-related diseases/ age-related diseases regulatory t-cell populations immunosenescence reflects age-related heightened pro-inflammatory phenotype urethane-induced lung carcinogenesis zeh hj 3rd

Questions {❓}

Can blocking inflammation enhance immunity during aging?
Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?
Macrophage Immunometabolism: Where Are We (Going)?
Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?
Sex differences in obesity, lipid metabolism, and inflammation-A role for the sex chromosomes?

Schema {🗺️}

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         headline:Macrophage function in the elderly and impact on injury repair and cancer
         description:Older age is associated with deteriorating health, including escalating risk of diseases such as cancer, and a diminished ability to repair following injury. This rise in age-related diseases/co-morbidities is associated with changes to immune function, including in myeloid cells, and is related to immunosenescence. Immunosenescence reflects age-related changes associated with immune dysfunction and is accompanied by low-grade chronic inflammation or inflammageing. This is characterised by increased levels of circulating pro-inflammatory cytokines such as tumor necrosis factor (TNF), interleukin (IL)-1β and IL-6. However, in healthy ageing, there is a concomitant age-related escalation in anti-inflammatory cytokines such as transforming growth factor-β1 (TGF-β1) and IL-10, which may overcompensate to regulate the pro-inflammatory state. Key inflammatory cells, macrophages, play a role in cancer development and injury repair in young hosts, and we propose that their role in ageing in these scenarios may be more profound. Imbalanced pro- and anti-inflammatory factors during ageing may also have a significant influence on macrophage function and further impact the severity of age-related diseases in which macrophages are known to play a key role. In this brief review we summarise studies describing changes to inflammatory function of macrophages (from various tissues and across sexes) during healthy ageing. We also describe age-related diseases/co-morbidities where macrophages are known to play a key role, focussed on injury repair processes and cancer, plus comment briefly on strategies to correct for these age-related changes.
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