Here's how LINK.SPRINGER.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1186/s40164-021-00252-z.

Title:
Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies | Experimental Hematology & Oncology
Description:
Macrophages are heterogeneous cells that present as different functional phenotypes due to their plasticity. They can be classified into two categories, namely M1- and M2-like macrophages, which are involved in processes as diverse as anti-tumor activity and immunosuppressive tumor promotion. Tumor-associated macrophages (TAMs) are defined as being of an M2-type and are considered as the active component in tumor microenvironment. TAMs are involved in multiple processes of tumor progression through the expression of cytokines, chemokines, growth factors, protein hydrolases and more, which lead to enhance tumor cell proliferation, angiogenesis, and immunosuppression, which in turn supports invasion and metastasis. It is assumed that the abundance of TAMs in major solid tumors is correlated to a negative patient prognosis. Because of the currently available data of the TAMs’ role in tumor development, these cells have emerged as a promising target for novel cancer treatment strategies. In this paper, we will briefly describe the origins and types of TAMs and will try to comprehensively show how TAMs contribute to tumorigenesis and disease progression. Finally, we will present the main TAM-based therapeutic strategies currently available.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,625,932 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

pubmed, article, google, scholar, cancer, cas, tams, cells, macrophages, tumor, central, cell, tumorassociated, metastasis, growth, targeting, ccl, macrophage, factor, treatment, wang, antitumor, immune, oncol, signaling, zhang, progression, therapeutic, tumors, invasion, receptor, tam, pathway, liu, expression, chen, res, microenvironment, angiogenesis, response, csfr, hematol, therapy, activation, ligand, stem, tme, polarization, emt, recruitment,

Topics {✒️}

jak2/stat3/mir-506-3p/foxq1 regulation granulocyte–macrophage colony-stimulating factor wnt/β-catenin signaling pathway monocyte-producing macrophage/dendritic progenitors anti-csf-1r antibody reveals activating β-catenin/stat3 signaling converts bone-marrow-derived macrophages wnt/β-catenin pathway tnf-related apoptosis-inducing ligand man-ha-mno2 nps macrophage colony-stimulating factor myeloid-derived suppressor cell csf1/csf1r-cxcl12/cxcr4 axis cutaneous t-cell lymphoma csf-1 colony-stimulating factor-1 anti-clever-1/anti-pd-1 inhibitor cd47-signal regulatory protein-α article download pdf induce epithelial-mesenchymal transition platelet-derived growth factor mannan-conjugated mno2 nanoparticles serine/threonine-protein kinase 1 anti-csf-1r antibodies resulted microrna-26a suppresses recruitment anti-pd-l1 treatment results lower progression-free survival antibody-dependent cellular cytotoxicity bioinspired exosome-mimetic nanovesicles harnessing macrophage-mediated degradation multi-omics signatures related tam–induced protein kinase jak2/stat3/snail pathway rhoa/rock signaling pathway anti-pd-l1 treatment led tumor necrosis factor-alpha castration-resistant prostate cancer anti-tumour strategies aiming anti-pd-l1 strengthened inducing pmn-mdsc infiltration antibody-dependent cellular phagocytosis myeloid-targeted immunotherapies act tie2hi macrophage-derived vegfa macrophage-mediated immune evasion anti-pd-1/pd-l1 g5-dendrimer nanoparticles loaded mir-26a expression inhibited multi-omics signatures performed adenoma-linked barrier defects tenosynovial giant-cell tumor blocking pd-1/pd-l1

Questions {❓}

  • Inflammation and cancer: back to Virchow?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies
         description:Macrophages are heterogeneous cells that present as different functional phenotypes due to their plasticity. They can be classified into two categories, namely M1- and M2-like macrophages, which are involved in processes as diverse as anti-tumor activity and immunosuppressive tumor promotion. Tumor-associated macrophages (TAMs) are defined as being of an M2-type and are considered as the active component in tumor microenvironment. TAMs are involved in multiple processes of tumor progression through the expression of cytokines, chemokines, growth factors, protein hydrolases and more, which lead to enhance tumor cell proliferation, angiogenesis, and immunosuppression, which in turn supports invasion and metastasis. It is assumed that the abundance of TAMs in major solid tumors is correlated to a negative patient prognosis. Because of the currently available data of the TAMs’ role in tumor development, these cells have emerged as a promising target for novel cancer treatment strategies. In this paper, we will briefly describe the origins and types of TAMs and will try to comprehensively show how TAMs contribute to tumorigenesis and disease progression. Finally, we will present the main TAM-based therapeutic strategies currently available.
         datePublished:2021-12-29T00:00:00Z
         dateModified:2022-02-03T00:00:00Z
         pageStart:1
         pageEnd:17
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s40164-021-00252-z
         keywords:
            Tumor-associated macrophages
            Tumor progression
            Therapeutic strategies
            Hematology
            Oncology
            Cancer Research
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs40164-021-00252-z/MediaObjects/40164_2021_252_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs40164-021-00252-z/MediaObjects/40164_2021_252_Fig2_HTML.png
         isPartOf:
            name:Experimental Hematology & Oncology
            issn:
               2162-3619
            volumeNumber:10
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Shuangli Zhu
               affiliation:
                     name:Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
                     address:
                        name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ming Yi
               affiliation:
                     name:Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
                     address:
                        name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yuze Wu
               affiliation:
                     name:Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
                     address:
                        name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bing Dong
               affiliation:
                     name:The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital
                     address:
                        name:Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Kongming Wu
               url:http://orcid.org/0000-0003-2499-1032
               affiliation:
                     name:Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
                     address:
                        name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
                        type:PostalAddress
                     type:Organization
                     name:The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital
                     address:
                        name:Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies
      description:Macrophages are heterogeneous cells that present as different functional phenotypes due to their plasticity. They can be classified into two categories, namely M1- and M2-like macrophages, which are involved in processes as diverse as anti-tumor activity and immunosuppressive tumor promotion. Tumor-associated macrophages (TAMs) are defined as being of an M2-type and are considered as the active component in tumor microenvironment. TAMs are involved in multiple processes of tumor progression through the expression of cytokines, chemokines, growth factors, protein hydrolases and more, which lead to enhance tumor cell proliferation, angiogenesis, and immunosuppression, which in turn supports invasion and metastasis. It is assumed that the abundance of TAMs in major solid tumors is correlated to a negative patient prognosis. Because of the currently available data of the TAMs’ role in tumor development, these cells have emerged as a promising target for novel cancer treatment strategies. In this paper, we will briefly describe the origins and types of TAMs and will try to comprehensively show how TAMs contribute to tumorigenesis and disease progression. Finally, we will present the main TAM-based therapeutic strategies currently available.
      datePublished:2021-12-29T00:00:00Z
      dateModified:2022-02-03T00:00:00Z
      pageStart:1
      pageEnd:17
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s40164-021-00252-z
      keywords:
         Tumor-associated macrophages
         Tumor progression
         Therapeutic strategies
         Hematology
         Oncology
         Cancer Research
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs40164-021-00252-z/MediaObjects/40164_2021_252_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs40164-021-00252-z/MediaObjects/40164_2021_252_Fig2_HTML.png
      isPartOf:
         name:Experimental Hematology & Oncology
         issn:
            2162-3619
         volumeNumber:10
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Shuangli Zhu
            affiliation:
                  name:Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
                  address:
                     name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ming Yi
            affiliation:
                  name:Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
                  address:
                     name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yuze Wu
            affiliation:
                  name:Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
                  address:
                     name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bing Dong
            affiliation:
                  name:The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital
                  address:
                     name:Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Kongming Wu
            url:http://orcid.org/0000-0003-2499-1032
            affiliation:
                  name:Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
                  address:
                     name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
                     type:PostalAddress
                  type:Organization
                  name:The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital
                  address:
                     name:Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Experimental Hematology & Oncology
      issn:
         2162-3619
      volumeNumber:10
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
      address:
         name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
         type:PostalAddress
      name:Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
      address:
         name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
         type:PostalAddress
      name:Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
      address:
         name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
         type:PostalAddress
      name:The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital
      address:
         name:Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China
         type:PostalAddress
      name:Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
      address:
         name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
         type:PostalAddress
      name:The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital
      address:
         name:Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Shuangli Zhu
      affiliation:
            name:Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
            address:
               name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
               type:PostalAddress
            type:Organization
      name:Ming Yi
      affiliation:
            name:Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
            address:
               name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
               type:PostalAddress
            type:Organization
      name:Yuze Wu
      affiliation:
            name:Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
            address:
               name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
               type:PostalAddress
            type:Organization
      name:Bing Dong
      affiliation:
            name:The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital
            address:
               name:Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Kongming Wu
      url:http://orcid.org/0000-0003-2499-1032
      affiliation:
            name:Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
            address:
               name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
               type:PostalAddress
            type:Organization
            name:The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital
            address:
               name:Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
      name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
      name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
      name:Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China
      name:Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
      name:Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China

External Links {🔗}(672)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

CDN Services {📦}

  • Crossref

5.46s.