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We began analyzing https://www.nature.com/articles/s41392-021-00823-w, but it redirected us to https://www.nature.com/articles/s41392-021-00823-w. The analysis below is for the second page.

Title[redir]:
T cell receptor (TCR) signaling in health and disease | Signal Transduction and Targeted Therapy
Description:
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes with the help of specific transcription factors. These signaling networks propagate with the help of various effector enzymes, such as kinases, phosphatases, and phospholipases. Integration of these disparate signal transduction pathways is done with the help of adaptor proteins that are non-enzymatic in function and that serve as a scaffold for various protein–protein interactions. This process aids in connecting the proximal to distal signaling pathways, thereby contributing to the full activation of T cells. This review provides a comprehensive snapshot of the various molecules involved in regulating T cell receptor signaling, covering both enzymes and adaptors, and will discuss their role in human disease.

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Keywords {🔍}

pubmed, article, google, scholar, cas, cell, cells, activation, central, signaling, tcr, tyrosine, protein, immunol, kinase, receptor, lck, phosphorylation, cancer, complex, biol, domain, adaptor, therapy, antigen, proteins, tcell, binding, slp, patients, role, regulation, zap, tumor, lat, immune, development, clinical, med, sci, kinases, molecules, pathway, activity, nat, nature, interaction, membrane, function, human,

Topics {✒️}

gm-csf/il3/il5 common β-chain nature portfolio cyclic-amp-responsive-element-binding protein privacy policy c-terminal cd3-epsilon-itam tyrosines ras–mek–erk–ap1 pathway advertising conserved t180-x-y182 motif single-molecule-fluorescence video imaging canonical pkcθ–ikkβ–nf-κβ pathway immuno-oncology research field c-jun n-terminal kinase wiskott–aldrich syndrome protein wiskott-aldrich syndrome protein x-linked lymphoproliferative syndrome-1 crkl–c3g–rap1-mediated signaling events fda-approved immune-checkpoint inhibitors e2-dependent ubiquitin-protein ligase fyn-t-fyb-slp-76 interactions define social media detergent-insoluble glycolipid-enriched membranes granulocyte–monocyte colony-stimulating factor ny-eso-1-specific tcr-engineered nf-kappa b-inducing kinase pkcθ–ikkβ–nf-κβ forms surgery research unit wiskott-aldrich syndrome patients pd-1/pd-l1 blockade monotherapy reprints guanine-nucleotide exchange activity protooncogene product p120c-cbl constitutive nf-kappab/rel activation t-cell receptor-mediated activation lymphocyte-antigen-presenting cell interface phospholipase c-gamma1-binding site pkb/akt-dependent cell survival crkl–c3g–rap1 signaling pathway ipilimumab-dependent cell-mediated cytotoxicity limits phosphatase access gamma/delta t-cell receptors multi-subunit immune-recognition receptors gamma/delta t-cell lymphomas mhc-restricted tcr-specific antigen akt-mediated nf-kappab activation translational cancer research chimeric antigen receptor-engineered dag–ras–mapk–erk1/2 pathway targeting ny-eso-1 antigen chimeric antigen receptor-modified mitogen-activated protein kinase

Questions {❓}

53 But why is TCR signaling not triggered in resting cells if free LCKs are available and apparently are more active than coreceptor-bound LCKs136?
Accessories or coreceptors?
Approval of first CAR-Ts: have we solved all hurdles for ATMPs?
CD4 and CD8: modulators of T-cell receptor recognition of antigen and of immune responses?
Gamma-delta (gammadelta) T cells: friend or foe in cancer development?
SH3 domain ligand binding: what’s the consensus and where’s the specificity?
What controls T cell receptor phosphorylation?
Why is there so much CD45 on T cells?

Schema {🗺️}

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