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Title[redir]:
Signaling role for Mg2+ revealed by immunodeficiency due to loss of MagT1 - PMC
Description:
The magnesium ion, Mg2+, is essential for all life as a cofactor for ATP, polyphosphates such as DNA and RNA, and metabolic enzymes, but whether it plays a role in intracellular signaling similar to Ca2+ is unknown. In this study, we identify ...
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Keywords {🔍}
doi, cells, fig, influx, magt, pubmed, google, scholar, activation, cell, patients, tcr, supplementary, signaling, free, stimulation, magnesium, patient, pmc, normal, plcγ, αcd, article, defect, expression, influxes, lymphocyte, receptor, deficiency, defects, control, immunodeficiency, human, defective, data, transporter, messenger, found, lymphocytes, protein, events, pdf, nlm, nature, healthy, mge, science, role, loss, mutations,
Topics {✒️}
performed x-chromosome exon-capture x-linked lymphoproliferative disease x-linked lymphoproliferative syndromes large n-terminal segment small c-terminal tail tumor necrosis factor-α x-linked primary immunodeficiencies magt1-mediated mg2+ influxes x-chromosome inactivation assay ms-icp data interpretation pmc beta search clear dose-dependent influx methylated x-chromosome dna x-linked genetic defect atp-requiring processes accounting receptor-induced phospholipase cγ1 tcr-induced cd69 upregulation magt1-deficiency profoundly delays 5 ug/ml anti-cd3 receptor-induced mg2+ influxes magnesium-generated process upstream tcr-induced mg2+ influx tcr-induced ca2+ influx mg2+-promoted ca2+ influxes single-read solexa sequencing tcr-stimulated mg2+ influx tcr-stimulated ca2+ influx magt1-dependent mg2+ influx bcr-induced mg2+ influxes apparent mg2+ influx bcr-induced ca2+ influx unexplained opportunistic infections carbachol-induced ca2+ influx egf-induced ca2+ influx epidermal growth factor full-length protein p65 nuclear translocation exhibited recurrent infections mammalian mg2+-selective transporter students t-test free cytoplasmic magnesium skewed lyonization reflects t-cell activation receptor-stimulated mg2+ flux cytosolic free mg2+ free intracellular [ca2+] transient sirna transfections percent nuclear p65 x-link immunodeficiency mitogen-induced activation
Questions {❓}
- Can magnesium act as a second messenger?
- X-linked lymphoproliferative syndromes: brothers or distant cousins?
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- What is the monthly revenue of https://doi.org/10.1126/science.2783497?
- What's the income generated by https://scholar.google.com/scholar_lookup?journal=Science&title=Contingent%20genetic%20regulatory%20events%20in%20T%20lymphocyte%20activation&author=GR%20Crabtree&volume=243&publication_year=1989&pages=355-361&pmid=2783497&doi=10.1126/science.2783497& each month?
- https://github.com/ncbi's total income per month
- What are the total earnings of https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323?
- Check the income stats for https://www.nlm.nih.gov/web_policies.html
- What's the monthly income of https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office?
- How much profit does https://www.hhs.gov/vulnerability-disclosure-policy/index.html make?
- How much does https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Amanuscript pull in?
- How much income is https://www.nlm.nih.gov/accessibility.html earning monthly?
- How much does https://www.nlm.nih.gov/careers/careers.html pull in?
- What are the total earnings of https://www.nlm.nih.gov/?
- How much does https://www.nih.gov/ gross monthly?
- Revenue of https://www.hhs.gov/
- How much does https://www.usa.gov/ bring in each month?
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