
NCBI . NLM . NIH . GOV {
}
Title[redir]:
A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation - PMC
Description:
Transmembrane protein tyrosine phosphatases, such as CD45, can act as both positive and negative regulators of cellular signaling. CD45 positively modulates T cell receptor (TCR) signaling by constitutively priming p56lck through the ...
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Keywords {๐}
tcr, doi, immunological, synapse, cell, pubmed, google, scholar, fig, mhcpeptide, cells, fluorescence, icam, min, data, pmc, tyrosine, region, density, accumulation, colocalization, central, open, article, planar, recovery, free, biol, signaling, engagement, contact, bilayers, labeled, moleculesฮผm, ring, thomas, receptor, green, fab, fragments, photobleaching, intensity, bilayer, supplemental, html, compartmentalization, center, formation, high, mature,
Topics {โ๏ธ}
c-terminal phosphorylation site poly-l-lysine control substrates oregon green-conjugated mhc-peptide i-ek-presenting agonist peptide free mhc-peptide complexes cold-competition immunoradiometric assays accumulated tcr/mhc-peptide clusters poly-l-lysine substrate lipid-anchored membrane proteins tcr-engaged mhc-peptide complexes pmc beta search maintain src-kinase activity fluorochrome-conjugated fab fragments [pubmed] [google scholar] accumulated mhc-peptide complexes activating mhc-peptide complexes maintain src-kinase molecules high-resolution ultrastructural studies parallel-plate flow cell antigen-presenting cell termed cell/antigen conjugates displaying peptide/mhc/icam substrate h57-alexa546 fab fragments poly-l-lysine tcr/mhc-peptide cluster large-scale receptor compartmentalization tcr-mediated calcium signaling integrin-mediated adhesion src-kinase molecules p56lck transmembrane tyrosine phosphatases dimensional diffusion half-time ฮฒ transgenic mice red/green/blue overlay supplementary materials included tyrosine phosphatase activity pnas web site mhc-peptide clusters mhc-peptide complexes publisher site pdf agonist peptide presented diffusion coefficient similar constitutively tyrosine phosphorylated src-kinase substrates cy-5-conjugated icam-1 planar lipid bilayers license information pmcid page abstract materials tyrosine phosphatase compartmentalization accumulated mhc-peptide cell/bilayer contact area
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