
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Tumor Microenvironment composition and severe cytokine release syndrome (CRS) Influence Toxicity in Patients with Large B Cell Lymphoma Treated with Axicabtagene Ciloleucel - PMC
Description:
One of the challenges of adoptive T cell therapy is the development of immune mediated toxicities including cytokine release syndrome (CRS) and neurotoxicity (NT). We aimed to identify factors that place patients at high risk of severe toxicity or ...
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Keywords {🔍}
patients, doi, severe, crs, toxicity, baseline, cell, levels, car, toxicities, google, scholar, pmc, cells, cytokine, pubmed, article, therapy, tumor, lymphoma, free, patient, axicel, clinical, figure, infusion, expression, gene, treated, prior, chemotherapy, grade, response, serum, day, disease, cytokines, data, pdf, immune, management, nihmssupplementpdf, release, syndrome, time, large, analysis, blood, mediated, lymphodepleting,
Topics {✒️}
chimeric antigen receptor-modified 75-base paired-end run kte-c19 anti-cd19 car chimeric antigen receptor stage iii/iv disease pmc beta search human cd19-targeted mouse high-throughput sequencing reads high-throughput sequencing data nucleic acid-sequencing libraries rna-seq expression profiles human cd4+cd25+ regulatory car-t-cell-therapy baseline pro-inflammatory state pro-inflammatory tumor microenvironment standard early cytokine-blockade myeloid-derived suppressor cells [google scholar] 33 [google scholar] 34 primary refractory disease blood-brain barrier disruption t-cell defect acute lymphoblastic leukemia clin cancer res cytokine release syndrome cytokine-release syndrome hyperactivated immune system pivotal axi-cel trials severe life-threatening crs ella correlated strongly transformed indolent lymphoma prospectively frozen material pro-inflammatory state de novo expression cell encephalopathy syndrome unfavorable tumor microenvironment molecular signatures database double hit dlbcl positive feedback loop release toxic amounts real-world population univariate logistic regression including objective responses license information pmcid renal insufficiency vte ang2/ang1 drawn prior prior autologous hsct high dose methylprednisolone rna-seq data immune effector cell
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- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi