
NCBI . NLM . NIH . GOV {
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Title[redir]:
Adapters in lymphocyte signaling - PMC
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Keywords {🔍}
doi, signaling, pubmed, google, scholar, cells, cell, slp, rafts, protein, activation, membrane, tyrosine, complex, proteins, lat, adapter, phosphorylation, domains, pag, pmc, src, binding, tcr, tbsms, function, kinase, molecules, traps, cainitiation, domain, free, article, biol, receptor, ptks, slap, activated, cytoplasmic, intracellular, interaction, phosphorylated, gads, plasma, plcγ, actin, regulation, csk, recent, science,
Topics {✒️}
ezrin-radixin-moesin family proteins glycosphingolipid-enriched microdomains/csk-binding protein paxillin/pkl/βpix/pak1 complex represents detergent-insoluble glycolipid-rich membranes tcr-induced nf-kappab activation transcription factors nf-κb x-linked lymphoproliferative syndrome pmc beta search protein kinase c-theta wiskott-aldrich syndrome protein x-linked agammaglobulinemia [xla] x-linked lymphoproliferative disease pak1-pix-pkl complex lat/grb2/sos complex cooperate degranulation-promoting adapter protein cell receptor–interacting molecule pmc copyright notice tyrosine-based signaling motifs graft-versus-host disease constitutively tyrosine-phosphorylated protein membrane-proximal signaling events tyrosine phosphorylation–dependent manner cell receptor-mediated signaling adhesion-regulated signalling complex membrane-adjacent signaling events src-family tyrosine kinases t-cell protein fyb activation-dependent membrane reconstruction zap-70 protein-tyrosine kinase t-cell receptor independent sphingoloipid-cholesterol rafts diffuse glycosphingolipid-enriched microdomains slp-65–deficient background fails epstein-barr virus skap-hom–deficient mice slap-130–deficient mice supports skap55/skap-hom show β1-mediated tyrosine phosphorylation t-cell receptor function lat-deficient jurkat variant small gtp-binding proteins constitutively tyrosine-phosphorylated pag slp-65–regulated signaling molecules glycolipid-enriched microdomains ca2+-initiation complex formation rescue tcr-mediated signaling ptk-mediated signaling pathway slap-130/fyb adapter protein btk-deficient patients provide c-terminal domains
Questions {❓}
- Are they associated there with particular seven–transmembrane domain receptors, or do rafts serve as storage compartments for these important signaling proteins?
- How, then, are these externally applied signals integrated to yield an appropriate immune response?
- Where do we go next?
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