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We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC2937550/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC2937550/. The analysis below is for the second page.
Title[redir]:
Myristoylation and Membrane Binding Regulate c-Src Stability and Kinase Activity - PMC
Description:
Myristoylation is critical for membrane association of Src kinases, but a role for myristate in regulating other aspects of Src biology has not been explored. In the c-Abl tyrosine kinase, myristate binds within a hydrophobic pocket at the base of ...
Title[redir]:
Myristoylation and Membrane Binding Regulate c-Src Stability and Kinase Activity - PMC
Description:
Myristoylation is critical for membrane association of Src kinases, but a role for myristate in regulating other aspects of Src biology has not been explored. In the c-Abl tyrosine kinase, myristate binds within a hydrophobic pocket at the base of ...
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Keywords {🔍}
csrc, kinase, cells, membrane, fig, pubmed, doi, myristate, pocket, google, scholar, src, csrcwt, activity, levels, binding, cos, myristoylation, cell, mutant, protein, nonmyristoylated, mutants, cbl, analyzed, transfected, csrcga, pmc, lysates, cabl, constructs, biol, article, residues, fyn, expression, forms, posttransfection, free, tyrosine, degradation, immunoprecipitated, ubiquitination, shown, cas, fraction, resh, association, antibodies, similar,
Topics {✒️}
full-length c-src protein rabbit polyclonal anti-c-src rabbit anti-phospho-c-src c-cbl-facilitated cytoskeletal effects y527f/g2a c-src exhibited high-molecular-weight ubiquitinated forms bcr-abl-dependent cell proliferation n-terminal glycine residue pmc beta search high-molecular-weight bands calcium-free state wild-type c-src negative-regulatory tyr527 residue resist proteasome-mediated degradation c-src affects ubiquitination mouse monoclonal anti-ptyr anti-phospho-c-srcy527 nonmyristoylated p60v-src fails tyrosine kinase c-src 10 μci [γ-32p]atp c-abl tyrosine kinase regulates c-src stability inhibits bcr-abl kinase purified wild-type cas plasmids encoding c-src orient c-src molecules n-terminally truncated forms ubiquitin-mediated degradation pathway n-terminal myristate group amino-terminal basic residues mutated n-terminal residue c-src kinase activity reversible protein-membrane interactions v-abl-transformed fibroblasts enzyme n-myristoyl transferase anti-phospho-c-src regulating steady-state levels c-terminal tail binds c-terminal tyr527 residue anchorage-independent cell growth n-terminal myristoylation site mouse monoclonal anti-fyn cells expressing c-srcwt membrane-targeting myristoyl group c-src kinase domain n-terminal myristate moiety c-src reveal features c-abl kinase domain atp-binding-site inhibitors membrane-targeting sh4 region
Questions {❓}
- How does myristate enhance the tyrosine kinase activity of c-Src?
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