
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Myeloid-Derived Suppressor Cells in Tumors: From Mechanisms to Antigen Specificity and Microenvironmental Regulation - PMC
Description:
Among the various immunological and non-immunological tumor-promoting activities of myeloid-derived suppressor cells (MDSCs), their immunosuppressive capacity remains a key hallmark. Effort in the past decade has provided us with a clearer view of ...
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Keywords {🔍}
cells, mdscs, doi, pubmed, google, scholar, tumor, pmc, suppressor, article, free, myeloidderived, cancer, cell, suppression, suppressive, tcell, immunol, expression, immune, myeloid, function, activity, production, response, microenvironment, mice, immunosuppressive, patients, pdl, tregs, wang, tgfβ, study, res, level, mmdscs, differentiation, activation, stress, antigenspecific, studies, shown, capacity, arg, jimmunol, zhang, induce, antigen, dcs,
Topics {✒️}
tumor-infiltrating b7-h3+cd14+hla-dr−/low subset anti-cd3/cd28-induced t-cell proliferation cd14+hla-dr−/low m-mdscs cd14+hla-dr−/low mdscs isolated cd11b+cd14+hla-dr−/lowcd15− cd14+hla-dr−/low mdscs interferon-gamma suppress anti-tumor autologous cd3/cd28-stimulated cd4+ cd33+cd11blowhla-drlow mdscs suppress cd14+ hla-dr- cells bone marrow-derived m-mdscs cxcl2/mif-cxcr2 signaling promotes tumor-derived prostaglandin-e2 blocks hla-dr−cd33+ cells mdsc-mediated t-cell suppression utilize membrane-bound tgf-β mdsc-derived tgf-β contributes antigen-specific t-cell tolerance tgf-beta-mtor-hif-1 signaling myeloid-derived suppressor cells orchestrating hif-1alpha-dependent glycolysis antigen-specific t-cell suppression acute graft-versus-host disease requires membrane-bound tgf-β1 glioma-infiltrating myeloid cells cd14+hla-dr dendritic cell-based vaccine mdsc-mediated antigen-specific suppression hif-1α-induced glycolytic activation mtor-mediated hif-1α induction gm-csf drives pd-l1 promote t-cell anergy pmc beta search inhibit t-cell responses reduces e-selectin expression tumor-infiltrating lymphocytes suppresses tumor-derived pro-inflammatory cytokines dnmt3a-dependent tolerogenic functions affect t-cell response gr-1+cd11b+ myeloid cells suppress t-cell function inhibits t-cell response pre-irradiated mammary tissue suppress anti-tumor immunity membrane-bound tgf-beta 1 er stress-related genes ifn-γ upregulates irf1 alleviated t-cell suppression x-box-binding protein 1 tumor-derived soluble mediators
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- Income figures for https://scholar.google.com/scholar_lookup?journal=Gastroenterology.&title=A%20new%20population%20of%20myeloid-derived%20suppressor%20cells%20in%20hepatocellular%20carcinoma%20patients%20induces%20CD4(+)CD25(+)Foxp3(+)%20T%20cells&author=B%20Hoechst&author=LA%20Ormandy&author=M%20Ballmaier&author=F%20Lehner&author=C%20Kruger&volume=135&publication_year=2008&pages=234-43&pmid=18485901&doi=10.1053/j.gastro.2008.03.020&
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- How much revenue does https://scholar.google.com/scholar_lookup?journal=Clin%20Cancer%20Res.&title=Lenalidomide%20enhances%20immune%20checkpoint%20blockade-induced%20immune%20response%20in%20multiple%20myeloma&author=G%20Gorgun&author=MK%20Samur&author=KB%20Cowens&author=S%20Paula&author=G%20Bianchi&volume=21&publication_year=2015&pages=4607-18&pmid=25979485&doi=10.1158/1078-0432.CCR-15-0200& generate?
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- How much money does https://scholar.google.com/scholar_lookup?journal=Cancer%20Immunol%20Immunother.&title=Liver%20myeloid-derived%20suppressor%20cells%20expand%20in%20response%20to%20liver%20metastases%20in%20mice%20and%20inhibit%20the%20anti-tumor%20efficacy%20of%20anti-CEA%20CAR-T&author=RA%20Burga&author=M%20Thorn&author=GR%20Point&author=P%20Guha&author=CT%20Nguyen&volume=64&publication_year=2015&pages=817-29&pmid=25850344&doi=10.1007/s00262-015-1692-6& generate?
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- How much revenue does https://scholar.google.com/scholar_lookup?journal=J%20Immunol.&title=Myeloid-derived%20suppressor%20cells%20accumulate%20in%20kidney%20allograft%20tolerance%20and%20specifically%20suppress%20effector%20T%20cell%20expansion&author=AS%20Dugast&author=T%20Haudebourg&author=F%20Coulon&author=M%20Heslan&author=F%20Haspot&volume=180&publication_year=2008&pages=7898-906&pmid=18523253&doi=10.4049/jimmunol.180.12.7898& produce monthly?
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- How much revenue does https://scholar.google.com/scholar_lookup?journal=J%20Immunol.&title=Fas%20signal%20promotes%20lung%20cancer%20growth%20by%20recruiting%20myeloid-derived%20suppressor%20cells%20via%20cancer%20cell-derived%20PGE2&author=Y%20Zhang&author=Q%20Liu&author=M%20Zhang&author=Y%20Yu&author=X%20Liu&volume=182&publication_year=2009&pages=3801-8&pmid=19265159&doi=10.4049/jimmunol.0801548& produce monthly?
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- How profitable is https://doi.org/10.3389/fimmu.2019.03070?
- Monthly income for https://scholar.google.com/scholar_lookup?journal=Front%20Immunol.&title=Deciphering%20the%20crosstalk%20between%20myeloid-derived%20suppressor%20cells%20and%20regulatory%20T%20cells%20in%20pancreatic%20ductal%20adenocarcinoma&author=C%20Siret&author=A%20Collignon&author=F%20Silvy&author=S%20Robert&author=T%20Cheyrol&volume=10&publication_year=2020&pages=3070&pmid=32038621&doi=10.3389/fimmu.2019.03070&
- What is the monthly revenue of https://doi.org/10.1158/0008-5472.CAN-07-6621?
- https://scholar.google.com/scholar_lookup?journal=Cancer%20Res.&title=Myeloid-derived%20suppressor%20cells%20promote%20cross-tolerance%20in%20B-cell%20lymphoma%20by%20expanding%20regulatory%20T%20cells&author=P%20Serafini&author=S%20Mgebroff&author=K%20Noonan&author=I%20Borrello&volume=68&publication_year=2008&pages=5439-49&pmid=18593947&doi=10.1158/0008-5472.CAN-07-6621& income
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- Financial intake of https://scholar.google.com/scholar_lookup?journal=J%20Immunol.&title=Tumor-infiltrating%20monocytic%20myeloid-derived%20suppressor%20cells%20mediate%20CCR5-dependent%20recruitment%20of%20regulatory%20T%20cells%20favoring%20tumor%20growth&author=E%20Schlecker&author=A%20Stojanovic&author=C%20Eisen&author=C%20Quack&author=CS%20Falk&volume=189&publication_year=2012&pages=5602-11&pmid=23152559&doi=10.4049/jimmunol.1201018&
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- Revenue of https://scholar.google.com/scholar_lookup?journal=Cancer%20Res.&title=CCL2%20produced%20by%20the%20glioma%20microenvironment%20is%20essential%20for%20the%20recruitment%20of%20regulatory%20T%20cells%20and%20myeloid-derived%20suppressor%20cells&author=AL%20Chang&author=J%20Miska&author=DA%20Wainwright&author=M%20Dey&author=CV%20Rivetta&volume=76&publication_year=2016&pages=5671-82&pmid=27530322&doi=10.1158/0008-5472.CAN-16-0144&
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- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Blood.&title=Plasticity%20of%20human%20Th17%20cells%20and%20iTregs%20is%20orchestrated%20by%20different%20subsets%20of%20myeloid%20cells&author=B%20Hoechst&author=J%20Gamrekelashvili&author=MP%20Manns&author=TF%20Greten&author=F%20Korangy&volume=117&publication_year=2011&pages=6532-41&pmid=21493801&doi=10.1182/blood-2010-11-317321&?
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- How profitable is https://scholar.google.com/scholar_lookup?journal=J%20Immunol.&title=Tumor-associated%20CD8+%20T%20cell%20tolerance%20induced%20by%20bone%20marrow-derived%20immature%20myeloid%20cells&author=S%20Kusmartsev&author=S%20Nagaraj&author=DI%20Gabrilovich&volume=175&publication_year=2005&pages=4583-92&pmid=16177103&doi=10.4049/jimmunol.175.7.4583&?
- What's the profit of https://doi.org/10.1189/jlb.0911465?
- https://scholar.google.com/scholar_lookup?journal=J%20Leukoc%20Biol.&title=Myeloid-derived%20suppressor%20cells%20from%20tumor-bearing%20mice%20impair%20TGF-beta-induced%20differentiation%20of%20CD4+CD25+FoxP3+%20Tregs%20from%20CD4+CD25-FoxP3-%20T%20cells&author=SM%20Centuori&author=M%20Trad&author=CJ%20LaCasse&author=D%20Alizadeh&author=CB%20Larmonier&volume=92&publication_year=2012&pages=987-97&pmid=22891289&doi=10.1189/jlb.0911465&'s revenue stream
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- Check the income stats for https://scholar.google.com/scholar_lookup?journal=J%20Immunol.&title=Tumor-derived%20lactate%20modifies%20antitumor%20immune%20response:%20effect%20on%20myeloid-derived%20suppressor%20cells%20and%20NK%20cells&author=Z%20Husain&author=Y%20Huang&author=P%20Seth&author=VP%20Sukhatme&volume=191&publication_year=2013&pages=1486-95&pmid=23817426&doi=10.4049/jimmunol.1202702&
- What's the profit of https://doi.org/10.1158/0008-5472.CAN-13-0545?
- What's the financial intake of https://scholar.google.com/scholar_lookup?journal=Cancer%20Res.&title=Tumor%20microenvironmental%20conversion%20of%20natural%20killer%20cells%20into%20myeloid-derived%20suppressor%20cells&author=YJ%20Park&author=B%20Song&author=YS%20Kim&author=EK%20Kim&author=JM%20Lee&volume=73&publication_year=2013&pages=5669-81&pmid=23867469&doi=10.1158/0008-5472.CAN-13-0545&?
- https://doi.org/10.1182/blood-2006-09-046201 income
- How much does https://scholar.google.com/scholar_lookup?journal=Blood.&title=Expansion%20of%20spleen%20myeloid%20suppressor%20cells%20represses%20NK%20cell%20cytotoxicity%20in%20tumor-bearing%20host&author=C%20Liu&author=S%20Yu&author=J%20Kappes&author=J%20Wang&author=WE%20Grizzle&volume=109&publication_year=2007&pages=4336-42&pmid=17244679&doi=10.1182/blood-2006-09-046201& net monthly?
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- What is the monthly revenue of https://doi.org/10.1172/JCI41936?
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- What's the monthly income of https://doi.org/10.1093/mmy/myv030?
- What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=Med%20Mycol.&title=Polymorphonuclear%20neutrophils%20and%20granulocytic%20myeloid-derived%20suppressor%20cells%20inhibit%20natural%20killer%20cell%20activity%20toward%20Aspergillus%20fumigatus&author=J%20Mueller-Leisse&author=S%20Brueggemann&author=M%20Bouzani&author=AL%20Schmitt&author=H%20Einsele&volume=53&publication_year=2015&pages=622-9&pmid=26026170&doi=10.1093/mmy/myv030&?
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- Revenue of https://doi.org/10.1111/cei.12143
- Financial intake of https://scholar.google.com/scholar_lookup?journal=Clin%20Exp%20Immunol.&title=Neutrophilic%20myeloid-derived%20suppressor%20cells%20in%20cord%20blood%20modulate%20innate%20and%20adaptive%20immune%20responses&author=N%20Rieber&author=C%20Gille&author=N%20Kostlin&author=I%20Schafer&author=B%20Spring&volume=174&publication_year=2013&pages=45-52&pmid=23701226&doi=10.1111/cei.12143&
- Profit of https://doi.org/10.1182/blood-2008-03-143776
- https://scholar.google.com/scholar_lookup?journal=Blood.&title=Mononuclear%20myeloid-derived%20%E2%80%9Csuppressor%E2%80%9D%20cells%20express%20RAE-1%20and%20activate%20natural%20killer%20cells&author=N%20Nausch&author=IE%20Galani&author=E%20Schlecker&author=A%20Cerwenka&volume=112&publication_year=2008&pages=4080-9&pmid=18753637&doi=10.1182/blood-2008-03-143776&'s financial summary
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- https://scholar.google.com/scholar_lookup?journal=Oncoimmunology.&title=Natural%20killer%20cells%20require%20monocytic%20Gr-1(+)/CD11b(+)%20myeloid%20cells%20to%20eradicate%20orthotopically%20engrafted%20glioma%20cells&author=GJ%20Baker&author=P%20Chockley&author=D%20Zamler&author=MG%20Castro&author=PR%20Lowenstein&volume=5&publication_year=2016&pages=e1163461&pmid=27471637&doi=10.1080/2162402X.2016.1163461&'s revenue stream
- What's the financial gain of https://doi.org/10.1084/jem.20080132?
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- What's https://scholar.google.com/scholar_lookup?journal=Cancer%20Res.&title=The%20biodistribution%20and%20immune%20suppressive%20effects%20of%20breast%20cancer-derived%20exosomes&author=SW%20Wen&author=J%20Sceneay&author=LG%20Lima&author=CS%20Wong&author=M%20Becker&volume=76&publication_year=2016&pages=6816-27&pmid=27760789&doi=10.1158/0008-5472.CAN-16-0868&'s gross income?
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- Monthly income for https://doi.org/10.1007/s12032-014-0453-2
- How much profit is https://scholar.google.com/scholar_lookup?journal=Med%20Oncol.&title=Exosomal%20Hsp70%20mediates%20immunosuppressive%20activity%20of%20the%20myeloid-derived%20suppressor%20cells%20via%20phosphorylation%20of%20Stat3&author=J%20Diao&author=X%20Yang&author=X%20Song&author=S%20Chen&author=Y%20He&volume=32&publication_year=2015&pages=453&pmid=25603952&doi=10.1007/s12032-014-0453-2& making per month?
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- What is the earnings of https://scholar.google.com/scholar_lookup?journal=J%20Biotechnol.&title=Myeloid-derived%20suppressor%20cells%20exhibit%20two%20bioenergetic%20steady-states%20in%20vitro&author=I%20Hammami&author=J%20Chen&author=V%20Bronte&author=G%20De%20Crescenzo&author=M%20Jolicoeur&volume=152&publication_year=2011&pages=43-8&pmid=21262283&doi=10.1016/j.jbiotec.2011.01.009&?
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- Profit of https://doi.org/10.1007/s00262-018-2177-1
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- How much revenue does https://doi.org/10.1002/hep.28655 bring in?
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- https://scholar.google.com/scholar_lookup?journal=J%20Exp%20Med.&title=HIF-1alpha%20regulates%20function%20and%20differentiation%20of%20myeloid-derived%20suppressor%20cells%20in%20the%20tumor%20microenvironment&author=CA%20Corzo&author=T%20Condamine&author=L%20Lu&author=MJ%20Cotter&author=JI%20Youn&volume=207&publication_year=2010&pages=2439-53&pmid=20876310&doi=10.1084/jem.20100587& income
- Financial intake of https://doi.org/10.1038/s41467-017-00530-7
- https://scholar.google.com/scholar_lookup?journal=Nat%20Commun.&title=Hypoxia%20inducible%20factor%20HIF-1%20promotes%20myeloid-derived%20suppressor%20cells%20accumulation%20through%20ENTPD2/CD39L1%20in%20hepatocellular%20carcinoma&author=DK%20Chiu&author=AP%20Tse&author=IM%20Xu&author=J%20Di%20Cui&author=RK%20Lai&volume=8&publication_year=2017&pages=517&pmid=28894087&doi=10.1038/s41467-017-00530-7&'s revenue stream
- Revenue of https://doi.org/10.1371/journal.ppat.1006616
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- https://scholar.google.com/scholar_lookup?journal=Cancer%20Immunol%20Res.&title=Hypoxia-induced%20VISTA%20promotes%20the%20suppressive%20function%20of%20myeloid-derived%20suppressor%20cells%20in%20the%20tumor%20microenvironment&author=J%20Deng&author=J%20Li&author=A%20Sarde&author=JL%20Lines&author=YC%20Lee&volume=7&publication_year=2019&pages=1079-90&pmid=31088847&doi=10.1158/2326-6066.CIR-18-0507& income
- How much cash flow does https://doi.org/10.1158/1078-0432.CCR-11-3028 have monthly?
- Income figures for https://scholar.google.com/scholar_lookup?journal=Clin%20Cancer%20Res.&title=Inhibition%20of%20the%20Kit%20ligand/c-Kit%20axis%20attenuates%20metastasis%20in%20a%20mouse%20model%20mimicking%20local%20breast%20cancer%20relapse%20after%20radiotherapy&author=F%20Kuonen&author=J%20Laurent&author=C%20Secondini&author=G%20Lorusso&author=JC%20Stehle&volume=18&publication_year=2012&pages=4365-74&pmid=22711708&doi=10.1158/1078-0432.CCR-11-3028&
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