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pubmed, article, google, scholar, cas, cell, cells, activation, central, signaling, tcr, tyrosine, protein, immunol, kinase, receptor, lck, phosphorylation, cancer, complex, biol, adaptor, domain, therapy, antigen, proteins, tcell, binding, slp, patients, role, regulation, zap, tumor, lat, immune, development, clinical, med, sci, molecules, kinases, pathway, activity, nat, nature, interaction, membrane, function, human,

Topics {✒️}

gm-csf/il3/il5 common β-chain nature portfolio cyclic-amp-responsive-element-binding protein privacy policy c-terminal cd3-epsilon-itam tyrosines ras–mek–erk–ap1 pathway advertising conserved t180-x-y182 motif single-molecule-fluorescence video imaging canonical pkcθ–ikkβ–nf-κβ pathway immuno-oncology research field c-jun n-terminal kinase wiskott–aldrich syndrome protein wiskott-aldrich syndrome protein fda-approved immune-checkpoint inhibitors x-linked lymphoproliferative syndrome-1 crkl–c3g–rap1-mediated signaling events e2-dependent ubiquitin-protein ligase fyn-t-fyb-slp-76 interactions define social media detergent-insoluble glycolipid-enriched membranes granulocyte–monocyte colony-stimulating factor ny-eso-1-specific tcr-engineered nf-kappa b-inducing kinase pkcθ–ikkβ–nf-κβ forms surgery research unit pd-1/pd-l1 blockade monotherapy wiskott-aldrich syndrome patients author information authors reprints guanine-nucleotide exchange activity protooncogene product p120c-cbl constitutive nf-kappab/rel activation t-cell receptor-mediated activation lymphocyte-antigen-presenting cell interface phospholipase c-gamma1-binding site crkl–c3g–rap1 signaling pathway pkb/akt-dependent cell survival ipilimumab-dependent cell-mediated cytotoxicity limits phosphatase access multi-subunit immune-recognition receptors gamma/delta t-cell receptors translational cancer research mhc-restricted tcr-specific antigen gamma/delta t-cell lymphomas akt-mediated nf-kappab activation chimeric antigen receptor-engineered targeting ny-eso-1 antigen dag–ras–mapk–erk1/2 pathway chimeric antigen receptor-modified

Questions {❓}

• 53 But why is TCR signaling not triggered in resting cells if free LCKs are available and apparently are more active than coreceptor-bound LCKs136?
• Accessories or coreceptors?
• Approval of first CAR-Ts: have we solved all hurdles for ATMPs?
• CD4 and CD8: modulators of T-cell receptor recognition of antigen and of immune responses?
• Gamma-delta (gammadelta) T cells: friend or foe in cancer development?
• SH3 domain ligand binding: what’s the consensus and where’s the specificity?
• What controls T cell receptor phosphorylation?
• Why is there so much CD45 on T cells?

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