
NCBI . NLM . NIH . GOV {
}
Title[redir]:
The CBM-opathies—A Rapidly Expanding Spectrum of Human Inborn Errors of Immunity Caused by Mutations in the CARD11-BCL10-MALT1 Complex - PMC
Description:
The caspase recruitment domain family member 11 (CARD11 or CARMA1)—B cell CLL/lymphoma 10 (BCL10)—MALT1 paracaspase (MALT1) [CBM] signalosome complex serves as a molecular bridge between cell surface antigen receptor signaling and the activation of ...
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Keywords {🔍}
card, normal, cell, scholar, pubmed, google, doi, patients, cells, malt, activation, mutations, signaling, pmc, article, free, nfκb, bcl, disease, cbm, complex, protein, immunol, deficiency, patient, human, clinical, infections, immunodeficiency, immune, benta, proliferation, mice, domain, nfkappab, receptor, atopic, antigen, kinase, figure, immunity, severe, role, including, carma, expression, jnk, impaired, negative, mutation,
Topics {✒️}
t-cell-receptor signaling network antigen receptor-induced nf-kappa c-jun n-terminal kinase agonist-selected t-cell development tcr-induced nf-kappab activation low-grade b-cell lymphoma nf-kappab-dependent lymphocyte activation nf-kappab-dependent gene transcription lubac-induced nf-kappab signaling constitutive/aberrant nf-κb signaling bcl10-mediated nf-kappab induction pmc beta search canonical nf-κb driven antigen receptor-induced activation canonical nf-kappab activity nucleation-induced filamentous assembly linear ubiquitination-mediated signaling genome-wide mouse mutagenesis b-cell receptor signaling card11-bcl10-malt1 complex henry normal signaling iκbα/nf-κb g-protein coupled receptors activates nuclear factor-kappab compromised nf-κb phosphorylation cell receptor-dependent activation carma1-mediated nf-kappab neonatal glutamine-enriched nutrition noncanonical nf-kappab activation nk cell-mediated cytotoxicity tcr-induced nf-kappa malt1 controls anti-fungal nf-κb subunits p50 nf-κb nuclear translocation cell-dependent conjugate vaccines nf-κb signaling defect nf kappab-activating protein constitutive nf-κb activation nf-κb inhibitor alpha unrestricted nf-κb activation replaces baff-receptor signals alanine-serine-cysteine transporter 2 undergo k48-linked ubiquitination c-type lectin receptors low-birth-weight infants ensure nf-kappab activation cell-dependent transfer model concluding remarks n-terminal card domain genetically confirmed cbm-opathies hla-matched unrelated donor
Questions {❓}
- Targeting MALT1 Proteolytic activity in immunity, inflammation and disease: Good or Bad?
- The CBM signalosome: potential therapeutic target for aggressive lymphoma?
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- Explore the financials of https://scholar.google.com/scholar_lookup?journal=Oncogene&title=A%20novel%20gene,%20MALT1%20at%2018q21,%20is%20involved%20in%20t(11;18)%20(q21;q21)%20found%20in%20low-grade%20B-cell%20lymphoma%20of%20mucosa-associated%20lymphoid%20tissue&author=T%20Akagi&author=M%20Motegi&author=A%20Tamura&author=R%20Suzuki&author=Y%20Hosokawa&volume=18&publication_year=1999&pages=5785-94&pmid=10523859&doi=10.1038/sj.onc.1203018&
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- How much does https://scholar.google.com/scholar_lookup?journal=Gene.&title=Identification%20of%20a%20novel%20mutation%20in%20ZAP70%20and%20prenatal%20diagnosis%20in%20a%20Turkish%20family%20with%20severe%20combined%20immunodeficiency%20disorder&author=E%20Karaca&author=E%20Karakoc-Aydiner&author=OF%20Bayrak&author=S%20Keles&author=S%20Sevli&volume=512&publication_year=2013&pages=189-93&pmid=23124046&doi=10.1016/j.gene.2012.10.062& gross monthly?
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