We are analyzing https://link.springer.com/article/10.1186/1478-811x-7-13.

Title:
Crk and CrkL adaptor proteins: networks for physiological and pathological signaling | Cell Communication and Signaling
Description:
The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of essential signal transduction pathways in humans and other organisms that act as major convergence points in tyrosine kinase signaling. Crk proteins integrate signals from a wide variety of sources, including growth factors, extracellular matrix molecules, bacterial pathogens, and apoptotic cells. Mounting evidence indicates that dysregulation of Crk proteins is associated with human diseases, including cancer and susceptibility to pathogen infections. Recent structural work has identified new and unusual insights into the regulation of Crk proteins, providing a rationale for how Crk can sense diverse signals and produce a myriad of biological responses.
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Keywords {🔍}

crk, pubmed, cas, google, scholar, article, cell, cells, phosphorylation, tyrosine, pcas, proteins, signaling, biol, domain, central, activation, abl, studies, dock, kinase, crkl, protein, binding, src, rac, figure, chem, human, cancer, domains, adhesion, role, growth, pathway, complex, adaptor, signal, vcrk, activity, shn, region, shc, interaction, oncogene, migration, hanafusa, family, transformation, rap,

Topics {✒️}

pro-x-x-pro-x-lys/arg unc-73/trio-mig-2/rhog signaling module e-cadherin-based cell-cell contacts x1-p2-p3-x4-p5 notch-dependent t-cell leukemia uanine-nucleotide releasing factor pubmed search combining ptyr-asp-x-pro c-src-crk-c3g-rap1 signaling analyze crk-phosphotyrosine-dependent interactions proto-oncogenic protein c-cbl chronic myelogenous leukemia c-crk link c-abl mediates rap1-induced adhesion v-crk-induced cell transformation crk-ii/tc10 signaling pathway fine-tune signals related article download pdf p130cas/crk/c3g ternary complex dock1/elmo rac-gef argues prolyl cis-trans isomerization p130cas/crk/dock180 ternary complex c-terminal src kinase achieve cis-trans isomerization c-abl kinase regulates src-dependent tyrosine phosphorylation transgenic mmtv-p130cas mouse proto-oncogene product p120cbl p130cas/crk/c3g-induced activation organized protein-protein networks ezrin-radixin-moesin proteins ras-induced cell transformations c-abl tyrosine kinase tyrosine phosphorylation-dependent manner jun nh2-terminal kinase met-induced cell motility preosteoblastic mc3t3-e1 cells src-family tyrosine kinases abl-dependent tyrosine phosphorylation conserved c-terminal region classic c-terminal region cytoskeleton-dependent tyrosine phosphorylation phosphoinositide 3-kinase/akt pathway adhesion-dependent actin reorganization regulated rho-dependent phosphorylation c-src activity requires proto-oncogene products abl aeruginosa adp-ribosylates crk c-terminal sh3 domain nerve growth factor

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Cote JF, Vuori K: GEF what?

Schema {🗺️}

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         description:The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of essential signal transduction pathways in humans and other organisms that act as major convergence points in tyrosine kinase signaling. Crk proteins integrate signals from a wide variety of sources, including growth factors, extracellular matrix molecules, bacterial pathogens, and apoptotic cells. Mounting evidence indicates that dysregulation of Crk proteins is associated with human diseases, including cancer and susceptibility to pathogen infections. Recent structural work has identified new and unusual insights into the regulation of Crk proteins, providing a rationale for how Crk can sense diverse signals and produce a myriad of biological responses.
         datePublished:2009-05-10T00:00:00Z
         dateModified:2009-05-10T00:00:00Z
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            Focal Adhesion Kinase
            Tyrosine Phosphorylation
            Chronic Myelogenous Leukemia
            Noonan Syndrome
            Tyrosine Kinase Oncogene
            Cell Biology
            Protein-Ligand Interactions
            Receptors
            Cytokines and Growth Factors
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      description:The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of essential signal transduction pathways in humans and other organisms that act as major convergence points in tyrosine kinase signaling. Crk proteins integrate signals from a wide variety of sources, including growth factors, extracellular matrix molecules, bacterial pathogens, and apoptotic cells. Mounting evidence indicates that dysregulation of Crk proteins is associated with human diseases, including cancer and susceptibility to pathogen infections. Recent structural work has identified new and unusual insights into the regulation of Crk proteins, providing a rationale for how Crk can sense diverse signals and produce a myriad of biological responses.
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      dateModified:2009-05-10T00:00:00Z
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         Tyrosine Phosphorylation
         Chronic Myelogenous Leukemia
         Noonan Syndrome
         Tyrosine Kinase Oncogene
         Cell Biology
         Protein-Ligand Interactions
         Receptors
         Cytokines and Growth Factors
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      name:Department of Pathology, Division of Medicine, Hokkaido University School of Medicine, Kita-ku, Japan

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