We are analyzing https://link.springer.com/article/10.1007/s000180050492.

Title:
The role of adapter proteins in T cell activation | Cellular and Molecular Life Sciences
Description:
Engagement of antigen receptors on lymphocytes leads to a myriad of complex signal transduction cascades. Recently, work from several laboratories has led to the identification and characterization of novel adapter molecules, proteins with no intrinsic enzymatic activity but which integrate signal transduction pathways by mediating protein-protein interactions. Interestingly, it appears that many of these adapter proteins play as critical a role as the effector enzymes themselves in both lymphocyte development and activation. This review describes some of the biochemical and molecular features of several of these newly identified hematopoietic cell-specific adapter molecules highlighting their importance in regulating (both positively and negatively) signal transduction mediated by the T cell antigen receptor.
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Keywords {🔍}

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Topics {✒️}

mediating protein-protein interactions month download article/chapter protein-protein interaction cell antigen receptor cell receptor signaling lymphocyte activation cell receptor cell activation antigen receptors privacy choices/manage cookies lymphocyte development adapter proteins play full article pdf signal transduction mediated european economic area scope submit manuscript intrinsic enzymatic activity conditions privacy policy adapter molecules accepting optional cookies related subjects main content log adapter proteins journal finder publish article cellular signal transduction cell check access instant access december 1999 volume 56 molecular features life sci information article log activation privacy policy personal data books a article koretzky article cite optional cookies manage preferences lymphocytes leads data protection essential cookies cookies skip subscription content similar content institution subscribe journal publish

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         headline:The role of adapter proteins in T cell activation
         description: Engagement of antigen receptors on lymphocytes leads to a myriad of complex signal transduction cascades. Recently, work from several laboratories has led to the identification and characterization of novel adapter molecules, proteins with no intrinsic enzymatic activity but which integrate signal transduction pathways by mediating protein-protein interactions. Interestingly, it appears that many of these adapter proteins play as critical a role as the effector enzymes themselves in both lymphocyte development and activation. This review describes some of the biochemical and molecular features of several of these newly identified hematopoietic cell-specific adapter molecules highlighting their importance in regulating (both positively and negatively) signal transduction mediated by the T cell antigen receptor.
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