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Title:
T cell receptor (TCR) signaling in health and disease | Signal Transduction and Targeted Therapy
Description:
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes with the help of specific transcription factors. These signaling networks propagate with the help of various effector enzymes, such as kinases, phosphatases, and phospholipases. Integration of these disparate signal transduction pathways is done with the help of adaptor proteins that are non-enzymatic in function and that serve as a scaffold for various proteināprotein interactions. This process aids in connecting the proximal to distal signaling pathways, thereby contributing to the full activation of T cells. This review provides a comprehensive snapshot of the various molecules involved in regulating T cell receptor signaling, covering both enzymes and adaptors, and will discuss their role in human disease.
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Keywords {š}
pubmed, article, google, scholar, cas, cell, cells, activation, central, signaling, tcr, tyrosine, protein, immunol, kinase, receptor, lck, phosphorylation, cancer, complex, biol, adaptor, domain, therapy, antigen, proteins, tcell, binding, slp, patients, role, regulation, zap, tumor, lat, immune, development, clinical, med, sci, molecules, kinases, pathway, activity, nat, nature, interaction, membrane, function, human,
Topics {āļø}
gm-csf/il3/il5 common β-chain nature portfolio cyclic-amp-responsive-element-binding protein privacy policy c-terminal cd3-epsilon-itam tyrosines rasāmekāerkāap1 pathway advertising conserved t180-x-y182 motif single-molecule-fluorescence video imaging canonical pkcĪøāikkβānf-κβ pathway immuno-oncology research field c-jun n-terminal kinase wiskottāaldrich syndrome protein wiskott-aldrich syndrome protein fda-approved immune-checkpoint inhibitors x-linked lymphoproliferative syndrome-1 crklāc3gārap1-mediated signaling events e2-dependent ubiquitin-protein ligase fyn-t-fyb-slp-76 interactions define social media detergent-insoluble glycolipid-enriched membranes granulocyteāmonocyte colony-stimulating factor ny-eso-1-specific tcr-engineered nf-kappa b-inducing kinase pkcĪøāikkβānf-κβ forms surgery research unit pd-1/pd-l1 blockade monotherapy wiskott-aldrich syndrome patients author information authors reprints guanine-nucleotide exchange activity protooncogene product p120c-cbl constitutive nf-kappab/rel activation t-cell receptor-mediated activation lymphocyte-antigen-presenting cell interface phospholipase c-gamma1-binding site crklāc3gārap1 signaling pathway pkb/akt-dependent cell survival ipilimumab-dependent cell-mediated cytotoxicity limits phosphatase access multi-subunit immune-recognition receptors gamma/delta t-cell receptors translational cancer research mhc-restricted tcr-specific antigen gamma/delta t-cell lymphomas akt-mediated nf-kappab activation chimeric antigen receptor-engineered targeting ny-eso-1 antigen dagārasāmapkāerk1/2 pathway chimeric antigen receptor-modified
Questions {ā}
- 53 But why is TCR signaling not triggered in resting cells if free LCKs are available and apparently are more active than coreceptor-bound LCKs136?
- Accessories or coreceptors?
- Approval of first CAR-Ts: have we solved all hurdles for ATMPs?
- CD4 and CD8: modulators of T-cell receptor recognition of antigen and of immune responses?
- Gamma-delta (gammadelta) T cells: friend or foe in cancer development?
- SH3 domain ligand binding: whatās the consensus and whereās the specificity?
- What controls T cell receptor phosphorylation?
- Why is there so much CD45 on T cells?
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