We are analyzing https://link.springer.com/article/10.1007/s00018-013-1393-2.

Title:
Transcriptional control of CD4 and CD8 coreceptor expression during T cell development | Cellular and Molecular Life Sciences
Description:
The differentiation and function of peripheral helper and cytotoxic T cell lineages is coupled with the expression of CD4 and CD8 coreceptor molecules, respectively. This indicates that the control of coreceptor gene expression is closely linked with the regulation of CD4/CD8 lineage decision of DP thymocytes. Research performed during the last two decades revealed comprehensive mechanistic insight into the developmental stage- and subset/lineage-specific regulation of Cd4, Cd8a and Cd8b1 (Cd8) gene expression. These studies provided important insight into transcriptional control mechanisms during T cell development and into the regulation of cis-regulatory networks in general. Moreover, the identification of transcription factors involved in the regulation of CD4 and CD8 significantly advanced the knowledge of the transcription factor network regulating CD4/CD8 cell-fate choice of DP thymocytes. In this review, we provide an overview of the identification and characterization of CD4/CD8 cis-regulatory elements and present recent progress in our understanding of how these cis-regulatory elements control CD4/CD8 expression during T cell development and in peripheral T cells. In addition, we describe the transcription factors implicated in the regulation of coreceptor gene expression and discuss how these factors are integrated into the transcription factor network that regulates CD4/CD8 cell-fate choice of DP thymocytes.
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Keywords {🔍}

expression, cells, gene, google, scholar, pubmed, cas, thymocytes, article, lineage, cell, development, thpok, cdcd, runx, transcription, mice, immunol, factors, silencer, regulation, class, enhancer, mhc, differentiation, coreceptor, factor, transcriptional, cdsp, cisregulatory, loci, choice, locus, complex, mature, cda, elements, enhancers, control, activity, complexes, essential, transgenic, littman, helper, genes, mazr, immunity, thymocyte, peripheral,

Topics {✒️}

mhc class ii-signaled cd4/cd8 cell-fate choice t-cell-specific enhancer adjacent lcmv-infected e8i-deficient mice basic helix-loop-helix genes t-cell-lineage developmental programme e8i/e8ii double-deficient mice runx3/cbfβ-dependent epigenetic programming cd4/cd8 cis-regulatory elements cis-regulatory elements controlling basic helix-loop-helix lena haust & roland tschismarov fung-leung wp cd4+cd8+ double-positive stage e-protein inhibitors id2 membrane-proximal invariant domains elongation factor p-tefb atp-dependent chromatin remodeling cd8/tcr-mhc class mediate protein–protein interactions cell–cell adhesion mediated zinc-finger protein mazr antigen-specific clonal expansion cis-regulatory elements directing cd4/cd8 lineage decision cd4-cd8 lineage decision hd-deficient background restored mhc class ii heb/e2a-null dp cells transcription factor network cd4/cd8 lineage choice cd4-cd8 lineage choice e8i/e8ii-deficient background article download pdf e8ii-deficient mice revealed cd8 cis-regulatory elements e12-related protein interacts major cis-regulatory elements positive-acting cis-elements negative-acting cis-element satb1-deficient mice display identify cis-regulatory elements transcription factors regulating suppresses runx-mediated commitment t-cell development revealed directs lineage-specific expression cell receptor alpha/beta chip-seq approaches revealed transcription factor networks e8i/e8ii-deficient mice

Questions {❓}

Davis CB, Littman DR (1994) Thymocyte lineage commitment: is it instructed or stochastic?
Robey E (1994) Introduction: commitment to CD4 and CD8 lineages–stochastic or instructive?
Which cis-regulatory element at the Cd4 locus represents the “maturation” enhancer and how is CD4 expression maintained in CD4+ effector T cells?
Von Boehmer H (1996) CD4/CD8 lineage commitment: back to instruction?

Schema {🗺️}

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         headline:Transcriptional control of CD4 and CD8 coreceptor expression during T cell development
         description:The differentiation and function of peripheral helper and cytotoxic T cell lineages is coupled with the expression of CD4 and CD8 coreceptor molecules, respectively. This indicates that the control of coreceptor gene expression is closely linked with the regulation of CD4/CD8 lineage decision of DP thymocytes. Research performed during the last two decades revealed comprehensive mechanistic insight into the developmental stage- and subset/lineage-specific regulation of Cd4, Cd8a and Cd8b1 (Cd8) gene expression. These studies provided important insight into transcriptional control mechanisms during T cell development and into the regulation of cis-regulatory networks in general. Moreover, the identification of transcription factors involved in the regulation of CD4 and CD8 significantly advanced the knowledge of the transcription factor network regulating CD4/CD8 cell-fate choice of DP thymocytes. In this review, we provide an overview of the identification and characterization of CD4/CD8 cis-regulatory elements and present recent progress in our understanding of how these cis-regulatory elements control CD4/CD8 expression during T cell development and in peripheral T cells. In addition, we describe the transcription factors implicated in the regulation of coreceptor gene expression and discuss how these factors are integrated into the transcription factor network that regulates CD4/CD8 cell-fate choice of DP thymocytes.
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      headline:Transcriptional control of CD4 and CD8 coreceptor expression during T cell development
      description:The differentiation and function of peripheral helper and cytotoxic T cell lineages is coupled with the expression of CD4 and CD8 coreceptor molecules, respectively. This indicates that the control of coreceptor gene expression is closely linked with the regulation of CD4/CD8 lineage decision of DP thymocytes. Research performed during the last two decades revealed comprehensive mechanistic insight into the developmental stage- and subset/lineage-specific regulation of Cd4, Cd8a and Cd8b1 (Cd8) gene expression. These studies provided important insight into transcriptional control mechanisms during T cell development and into the regulation of cis-regulatory networks in general. Moreover, the identification of transcription factors involved in the regulation of CD4 and CD8 significantly advanced the knowledge of the transcription factor network regulating CD4/CD8 cell-fate choice of DP thymocytes. In this review, we provide an overview of the identification and characterization of CD4/CD8 cis-regulatory elements and present recent progress in our understanding of how these cis-regulatory elements control CD4/CD8 expression during T cell development and in peripheral T cells. In addition, we describe the transcription factors implicated in the regulation of coreceptor gene expression and discuss how these factors are integrated into the transcription factor network that regulates CD4/CD8 cell-fate choice of DP thymocytes.
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         Coreceptor gene expression
         Transcription factors
         CD4/CD8 lineage decision
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
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