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Title[redir]:
The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma - PMC
Description:
Blocking the interaction between the programmed cell death (PD)-1 protein and one of its ligands, PD-L1, has been reported to have impressive antitumor responses. Therapeutics targeting this pathway are currently in clinical trials. Pembrolizumab ...
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Keywords {🔍}
pdl, doi, patients, response, melanoma, google, scholar, nivolumab, pubmed, tumor, blockade, cell, expression, clinical, cells, ipilimumab, pmc, cancer, article, tumors, immune, phase, free, nct, treatment, trials, igg, combination, rates, antipd, antibody, benefit, pembrolizumab, death, mpdla, reported, therapy, survival, events, clin, ctla, adverse, trial, responses, study, programmed, activity, inhibitors, pathway, checkpoint,
Topics {✒️}
line-melanoma-study-nivolumab-investigational-pd-1-checkpoint-inhibitor- 89 anti-pd-l1 antibody mpdl-3280a single-agent anti-programmed death-1 single-agent immune-checkpoint inhibition anti-pd-l1 monoclonal antibody pd-l2-fc fusion protein human anti-pd-l1 antibody itim motif-carrying immunoreceptor tumor-specific t-lymphocyte activity infected wild-type mice pd-l1– anti-pd-1 antibody‡ cytotoxic t-lymphocyte antigen murine anti-human b7-h1 t-lymphocyte activation lies anti-pd-l1 antibody mpdl3280a immune-mediated events occurred anti-pd-1 monoclonal antibody immune-related adverse events pd-1/pd-l1–targeted therapies mouse strain 129s4/svjae pd-1/pd-l1 checkpoint inhibitors anti-pd-l1 clone 5h1 lupus-prone lpr mutation engineered pd-l1 antibody �exhausted” t-cell phenotype rabbit anti-human mab intratumoral t-regulatory cells early t-lymphocyte tolerance anti-pd-l1 antibody 11 anti-pd-l1 antibody anti-pd-l1 blockades treatment-related adverse events pmc beta search graft-versus-leukemia effect anti-pd-1 therapeutic agent induce pd-l1 expression experienced dose-limiting toxicity graft-versus-host disease single immune-checkpoint inhibitor anti-pd-1 pathway family details unpublished pd-l1 anti-pd-l1 blockade anti-pd-1 antibody nivolumab immune-checkpoint inhibitors benefits antibody/tumor type/treatment immune-related response criteria b7-deficient mice reveal pd-l1 knockout mouse complement-dependent cytotoxicity anti-pd-l1 agents
Questions {❓}
- Is PD-L1 Expression in Tumors a Predictive Biomarker?
- The evolution of checkpoint blockade as a cancer therapy: what’s here, what’s next?
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- Learn how profitable https://doi.org/10.1093/intimm/dxh194 is on a monthly basis
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- What's the profit of https://doi.org/10.1084/jem.185.3.393?
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- How profitable is https://doi.org/10.1016/j.immuni.2007.05.016?
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- How much does https://scholar.google.com/scholar_lookup?journal=Biochem%20Biophys%20Res%20Commun&title=Differential%20binding%20properties%20of%20B7-H1%20and%20B7-DC%20to%20programmed%20death-1&author=P%20Youngnak&author=Y%20Kozono&author=H%20Kozono&volume=307&publication_year=2003&pages=672-677&pmid=12893276&doi=10.1016/s0006-291x(03)01257-9& pull in monthly?
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- What are the total earnings of https://doi.org/10.1158/1078-0432.CCR-07-4079?
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- What's the income generated by https://scholar.google.com/scholar_lookup?journal=Lancet%20Oncol&title=Safety%20and%20activity%20of%20PD1%20blockade%20by%20pidilizumab%20in%20combination%20with%20rituximab%20in%20patients%20with%20relapsed%20follicular%20lymphoma:%20a%20single%20group,%20open-label,%20phase%202%20trial&author=JR%20Westin&author=F%20Chu&author=M%20Zhang&volume=15&publication_year=2014&pages=69-77&pmid=24332512&doi=10.1016/S1470-2045(13)70551-5& each month?
- Monthly income for https://doi.org/10.1158/2326-6066.CIR-14-0040
- Profit of https://scholar.google.com/scholar_lookup?journal=Cancer%20Immunol%20Res&title=In%20vitro%20characterization%20of%20the%20anti-pd-1%20antibody%20nivolumab,%20BMS-936558,%20and%20in%20vivo%20toxicology%20in%20non-human%20primates&author=C%20Wang&author=KB%20Thudium&author=M%20Han&volume=2&publication_year=2014&pages=846-856&pmid=24872026&doi=10.1158/2326-6066.CIR-14-0040&
- https://scholar.google.com/scholar_lookup?journal=J%20Clin%20Oncol&title=Clinical%20activity,%20safety,%20and%20biomarkers%20of%20MPDL3280A,%20an%20engineered%20PD-L1%20antibody%20in%20patients%20with%20locally%20advanced%20or%20metastatic%20melanoma%20(mM)&author=O%20Hamid&author=JA%20Sosman&author=DP%20Lawrence&volume=31&issue=suppl;%20abstr%209010&publication_year=2013&'s revenue stream
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- How much revenue does https://doi.org/10.1073/pnas.0406351101 bring in?
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&title=Costimulatory%20B7-H1%20in%20renal%20cell%20carcinoma%20patients:%20Indicator%20of%20tumor%20aggressiveness%20and%20potential%20therapeutic%20target&author=RH%20Thompson&author=MD%20Gillett&author=JC%20Cheville&volume=101&publication_year=2004&pages=17174-17179&pmid=15569934&doi=10.1073/pnas.0406351101&?
- Find out how much https://doi.org/10.1002/cncr.25747 earns monthly
- How much income does https://scholar.google.com/scholar_lookup?journal=Cancer&title=Overall%20survival%20and%20PD-L1%20expression%20in%20metastasized%20malignant%20melanoma&author=J%20Gadiot&author=AI%20Hooijkaas&author=AD%20Kaiser&volume=117&publication_year=2011&pages=2192-2201&pmid=21523733&doi=10.1002/cncr.25747& have?
- Profit of https://doi.org/10.1002/cncr.24899
- Earnings of https://scholar.google.com/scholar_lookup?journal=Cancer&title=Tumor%20cell%20expression%20of%20programmed%20cell%20death-1%20ligand%201%20is%20a%20prognostic%20factor%20for%20malignant%20melanoma&author=R%20Hino&author=K%20Kabashima&author=Y%20Kato&volume=116&publication_year=2010&pages=1757-1766&pmid=20143437&doi=10.1002/cncr.24899&
- What's the financial intake of https://doi.org/10.1126/scitranslmed.3003689?
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- How much profit does https://doi.org/10.1056/NEJMoa1113205 generate?
- How much revenue does https://scholar.google.com/scholar_lookup?journal=N%20Engl%20J%20Med&title=Intratumor%20heterogeneity%20and%20branched%20evolution%20revealed%20by%20multiregion%20sequencing&author=M%20Gerlinger&author=AJ%20Rowan&author=S%20Horswell&volume=366&publication_year=2012&pages=883-892&pmid=22397650&doi=10.1056/NEJMoa1113205& bring in?
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- What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Clin%20Cancer%20Res&title=Association%20of%20PD-1,%20PD-1%20ligands,%20and%20other%20features%20of%20the%20tumor%20immune%20microenvironment%20with%20response%20to%20anti-PD-1%20therapy&author=JM%20Taube&author=AP%20Klein&author=JR%20Brahmer&publication_year=2014&pmid=24714771&doi=10.1158/1078-0432.CCR-13-3271&?
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- How much income does https://doi.org/10.1016/j.ccr.2014.03.033 have?
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- See how much https://doi.org/10.1038/nature13904 makes per month
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- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=J%20Clin%20Oncol&title=A%20phase%20Ib%20study%20of%20MK-3475%20in%20patients%20with%20human%20papillomavirus%20(HPV)-associated%20and%20non-HPV%E2%80%93associated%20head%20and%20neck%20(H/N)%20cancer&author=T%20Seiwert&author=B%20Burtness&author=J%20Weiss&volume=32&issue=suppl;%20abstr%206011&publication_year=2014&?
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- How much money does https://doi.org/10.1084/jem.20130579 make?
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- How much revenue does https://doi.org/10.1158/2326-6066.CIR-13-0013 generate?
- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Cancer%20Immunol%20Res&title=Anti-CTLA-4%20antibodies%20of%20IgG2a%20isotype%20enhance%20antitumor%20activity%20through%20reduction%20of%20intratumoral%20regulatory%20T%20cells&author=MJ%20Selby&author=JJ%20Engelhardt&author=M%20Quigley&volume=1&publication_year=2013&pages=32-42&pmid=24777248&doi=10.1158/2326-6066.CIR-13-0013&?
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- https://doi.org/10.1016/j.coi.2015.01.006's financial summary
- How much money does https://scholar.google.com/scholar_lookup?journal=Curr%20Opin%20Immunol&title=The%20evolution%20of%20checkpoint%20blockade%20as%20a%20cancer%20therapy:%20what%E2%80%99s%20here,%20what%E2%80%99s%20next?&author=DS%20Shin&author=A%20Ribas&volume=33C&publication_year=2015&pages=23-35&pmid=25621841&doi=10.1016/j.coi.2015.01.006& generate?
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