We are analyzing https://link.springer.com/article/10.1007/s00424-007-0238-y.

Title:
Calcium-dependent transcription of cytokine genes in T lymphocytes | Pflügers Archiv - European Journal of Physiology
Description:
The increase in intracellular calcium ion concentration is a general signaling mechanism used in many biological systems. In T lymphocytes, calcium is essential for activation, differentiation, and effector functions. In this study, we will summarize recent developments of how intracellular calcium concentrations are modified in T cells to affect the activity of three major calcium-dependent transcriptional effectors, i.e., NFAT, MEF2, and DREAM, involved in cytokine gene expression.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,643,328 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

article, google, scholar, pubmed, cas, cell, calcium, biol, factor, transcription, protein, nfat, rao, chem, cells, gene, expression, nature, kinase, signaling, mef, channels, channel, immunol, cytokine, lymphocytes, nuclear, immunity, naranjo, activation, enhancer, nat, liu, savignac, regulatory, glimcher, differentiation, transcriptional, interleukin, usa, dream, influx, calcineurin, storeoperated, regulates, nfatc, science, hogan, mol, proc,

Topics {✒️}

ca2+-store-depletion-triggered ca2+ influx genome-wide rnai screen calcium-release-activated calcium channel a-type potassium channels month download article/chapter l-type calcium channels voltage-dependent calcium channels intracellular calcium-store depletion store-operated htrp3 channels store-operated ca2+ channels store-operated ca2+ entry major alpha pore-forming blocking protein–protein interaction proto-oncogene c-maf dihydropyridine-sensitive calcium response 2-acetyl-sn-glycerol-sensitive calcineurin-dependent gene expression interferon-gamma gene expression ca2+-regulated transcriptional repressor cell-type-restricted binding oliveira-dos-santos aj distinct tissue-specific activities lymphocyte calcium signaling canonical nf-κb signaling calcium-dependent transcription ca2+/calcineurin signalling syndrome critical region dnase i-hypersensitive site nf-atp-deficient mice ca2+-induced release calcium-binding protein mef2 transcription factors regulates interleukin-2 transcription calcium-dependent activation full article pdf cgmp/protein kinase influx identifies genes critical transcriptional repressor selective cation channel myocyte enhancer factor-2 intracellular calcium concentrations ca2+-dependent block dihydropyridine sensitive channels interferon regulatory factor-4 calcium signaling module glycogen synthase kinase-3 intracellular calcium sensor il-4 gene transcription european economic area transcription factor junb

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Calcium-dependent transcription of cytokine genes in T lymphocytes
         description:The increase in intracellular calcium ion concentration is a general signaling mechanism used in many biological systems. In T lymphocytes, calcium is essential for activation, differentiation, and effector functions. In this study, we will summarize recent developments of how intracellular calcium concentrations are modified in T cells to affect the activity of three major calcium-dependent transcriptional effectors, i.e., NFAT, MEF2, and DREAM, involved in cytokine gene expression.
         datePublished:2007-03-02T00:00:00Z
         dateModified:2007-03-02T00:00:00Z
         pageStart:523
         pageEnd:533
         sameAs:https://doi.org/10.1007/s00424-007-0238-y
         keywords:
            Calcium
            Cytokines
            T lymphocytes
            Transcription
            NFAT
            MEF2
            DREAM
            Human Physiology
            Molecular Medicine
            Neurosciences
            Cell Biology
            Receptors
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00424-007-0238-y/MediaObjects/424_2007_238_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00424-007-0238-y/MediaObjects/424_2007_238_Fig2_HTML.gif
         isPartOf:
            name:Pflügers Archiv - European Journal of Physiology
            issn:
               1432-2013
               0031-6768
            volumeNumber:454
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Magali Savignac
               affiliation:
                     name:Consejo Superior de Investigaciones Cientificas
                     address:
                        name:Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Britt Mellström
               affiliation:
                     name:Consejo Superior de Investigaciones Cientificas
                     address:
                        name:Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jose R. Naranjo
               affiliation:
                     name:Consejo Superior de Investigaciones Cientificas
                     address:
                        name:Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Calcium-dependent transcription of cytokine genes in T lymphocytes
      description:The increase in intracellular calcium ion concentration is a general signaling mechanism used in many biological systems. In T lymphocytes, calcium is essential for activation, differentiation, and effector functions. In this study, we will summarize recent developments of how intracellular calcium concentrations are modified in T cells to affect the activity of three major calcium-dependent transcriptional effectors, i.e., NFAT, MEF2, and DREAM, involved in cytokine gene expression.
      datePublished:2007-03-02T00:00:00Z
      dateModified:2007-03-02T00:00:00Z
      pageStart:523
      pageEnd:533
      sameAs:https://doi.org/10.1007/s00424-007-0238-y
      keywords:
         Calcium
         Cytokines
         T lymphocytes
         Transcription
         NFAT
         MEF2
         DREAM
         Human Physiology
         Molecular Medicine
         Neurosciences
         Cell Biology
         Receptors
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00424-007-0238-y/MediaObjects/424_2007_238_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00424-007-0238-y/MediaObjects/424_2007_238_Fig2_HTML.gif
      isPartOf:
         name:Pflügers Archiv - European Journal of Physiology
         issn:
            1432-2013
            0031-6768
         volumeNumber:454
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Magali Savignac
            affiliation:
                  name:Consejo Superior de Investigaciones Cientificas
                  address:
                     name:Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Britt Mellström
            affiliation:
                  name:Consejo Superior de Investigaciones Cientificas
                  address:
                     name:Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jose R. Naranjo
            affiliation:
                  name:Consejo Superior de Investigaciones Cientificas
                  address:
                     name:Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Pflügers Archiv - European Journal of Physiology
      issn:
         1432-2013
         0031-6768
      volumeNumber:454
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Consejo Superior de Investigaciones Cientificas
      address:
         name:Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
         type:PostalAddress
      name:Consejo Superior de Investigaciones Cientificas
      address:
         name:Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
         type:PostalAddress
      name:Consejo Superior de Investigaciones Cientificas
      address:
         name:Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Magali Savignac
      affiliation:
            name:Consejo Superior de Investigaciones Cientificas
            address:
               name:Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Britt Mellström
      affiliation:
            name:Consejo Superior de Investigaciones Cientificas
            address:
               name:Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Jose R. Naranjo
      affiliation:
            name:Consejo Superior de Investigaciones Cientificas
            address:
               name:Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
      name:Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
      name:Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(363)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.98s.

LINK . SPRINGER . COM {}