
DOI . ORG {
}
Title[redir]:
Epigenetic regulation of breast cancer metastasis | Cancer and Metastasis Reviews
Description:
Breast cancer is the most frequently diagnosed malignancy and the second leading cause of cancer-related mortality among women worldwide. Recurrent metastasis is associated with poor patient outcomes and poses a significant challenge in breast cancer therapies. Cancer cells adapting to a new tissue microenvironment is the key event in distant metastasis development, where the disseminating tumor cells are likely to acquire genetic and epigenetic alterations during the process of metastatic colonization. Despite several decades of research in this field, the exact mechanisms governing metastasis are not fully understood. However, emerging body of evidence indicates that in addition to genetic changes, epigenetic reprogramming of cancer cells and the metastatic niche are paramount toward successful metastasis. Here, we review and discuss the latest knowledge about the salient attributes of metastasis and epigenetic regulation in breast cancer and crucial research domains that need further investigation.
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Keywords {π}
pubmed, cancer, scholar, google, article, cas, breast, central, metastasis, cell, cells, research, journal, metastatic, tumor, nature, epigenetic, molecular, methylation, histone, stem, dna, oncology, clinical, expression, gene, human, progression, biology, promotes, transition, signaling, therapy, bone, regulation, reports, epithelialmesenchymal, cancers, triplenegative, primary, patients, reviews, niche, epigenetics, treatment, metastases, tumors, communications, mdig, thakur,
Topics {βοΈ}
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Questions {β}
- At last, a predictive and prognostic marker for radiotherapy?
- EMT and MET: Necessary or permissive for metastasis?
- Intra-tumour heterogeneity: A looking glass for cancer?
- Linking PRMT5 to breast cancer stem cells: New therapeutic opportunities?
- The pre-metastatic niche: Is metastasis random?
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headline:Epigenetic regulation of breast cancer metastasis
description:Breast cancer is the most frequently diagnosed malignancy and the second leading cause of cancer-related mortality among women worldwide. Recurrent metastasis is associated with poor patient outcomes and poses a significant challenge in breast cancer therapies. Cancer cells adapting to a new tissue microenvironment is the key event in distant metastasis development, where the disseminating tumor cells are likely to acquire genetic and epigenetic alterations during the process of metastatic colonization. Despite several decades of research in this field, the exact mechanisms governing metastasis are not fully understood. However, emerging body of evidence indicates that in addition to genetic changes, epigenetic reprogramming of cancer cells and the metastatic niche are paramount toward successful metastasis. Here, we review and discuss the latest knowledge about the salient attributes of metastasis and epigenetic regulation in breast cancer and crucial research domains that need further investigation.
datePublished:2023-10-19T00:00:00Z
dateModified:2023-10-19T00:00:00Z
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Oncology
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