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Keywords {🔍}

exosomes, cells, pubmed, cancer, article, google, scholar, cas, premetastatic, tumor, niche, metastasis, cell, central, exosome, immune, patients, pdl, formation, biomarkers, vascular, expression, microenvironment, extracellular, promote, metastatic, angiogenesis, tumorderived, zhang, factors, potential, rna, inflammatory, addition, effects, prognosis, melanoma, human, lung, res, httpsdoiorgs, nat, matrix, therapy, treatment, biol, function, tumors, niches, studies,

Topics {✒️}

tgf-βr1/tgf-βr2 signaling pathway microparticles mediated cross-talk anti-pd-1/pd-l1 antibodies triple-negative breast cancers bone marrow-derived cells anti-pd-1/pd-l1 therapy bone marrow-derived macrophages myeloid-derived suppressor cells article download pdf castration-resistant prostate cancer pre-metastatic niche refers pre-metastatic niche terminate anti-pd-1 immunotherapy enhanced hypoxia-induced lysyl oxidase tumor-cell-derived microvesicles destination-seeking behavior involves tumor-derived exosomes prepare exosome-derived pd-l1 microenvironment-induced pten loss tumour-induced systemic environment pre-metastatic niche depends exosomal pd-l1 contributes pro-metastatic vascular niche pre-metastatic niche formation transforming growth factor-β pd-1/pd-l1 blockers [36] anti-tumor immune response destructing blood-brain barrier triple-negative breast cancer cancer-derived extracellular vesicles stromal cell-derived exosomes exosome-mediated intercellular communication pd-1/pd-l1 inhibitors pd-1/pd-l1 pathway control bxpc-3-lit exosomes mediate hypoxia-dependent activation decreased pten upregulates bxpc-3-lit exosomes compared inhibit antigen-presenting cells promotes tumor growth tumor-derived exosomes upregulate anti-pd-1 antibodies reduces dc maturation induce vascular leakage exosome-mediated transfer regulate immune function vascular endothelial barrier stimulating g-csf production technological research project pre-metastatic niche

Questions {❓}

• After the primary tumor is surgically removed, does the effect of the exosomes on the pre-metastatic niche terminate?
• How can the theoretical basis of exosomes and pre-metastatic niches be applied to clinical treatment?
• How do tumor-derived exosomes upregulate the expression of proinflammatory S100?
• The composition of exosomes is complex, so what role do these components play?
• What is the difference in effect between tumor-derived exosomes and immune cell- or stromal cell-derived exosomes on the pre-metastatic niche?
• What is the reliability and validity of using exosomes as biomarkers to judge tumor metastasis?

Schema {🗺️}

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            name:The First Affiliated Hospital of Zhengzhou University
            address:
               name:Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Zhenyu Ji
      affiliation:
            name:Zhengzhou University
            address:
               name:Henan Academy of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
               type:PostalAddress
            type:Organization
            name:Zhengzhou University
            address:
               name:Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China
               type:PostalAddress
            type:Organization
            name:Zhengzhou University
            address:
               name:School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Zhenqiang Sun
      url:http://orcid.org/0000-0001-5926-2716
      affiliation:
            name:The First Affiliated Hospital of Zhengzhou University
            address:
               name:Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
               type:PostalAddress
            type:Organization
            name:Zhengzhou University
            address:
               name:Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China
               type:PostalAddress
            type:Organization
            name:Xinjiang Medical University
            address:
               name:Department of Gastrointestinal Surgery, Affiliated Tumor Hospital, Xinjiang Medical University, Ürümqi, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Henan Academy of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
      name:Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China
      name:School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China
      name:Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
      name:Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
      name:Henan Academy of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
      name:Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
      name:Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
      name:Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China
      name:Department of Pathology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
      name:Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
      name:Department of Gastrointestinal Surgery, Affiliated Tumor Hospital, Xinjiang Medical University, Ürümqi, China
      name:Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
      name:Henan Academy of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
      name:Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China
      name:School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China
      name:Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
      name:Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China
      name:Department of Gastrointestinal Surgery, Affiliated Tumor Hospital, Xinjiang Medical University, Ürümqi, China

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